Term
|
Definition
1. Host Factors
- Innate immunity (Th1/Th2 phenotype, "Hygeine Hypothesis)
- Genetics
- Sex
2. Environmental Factors
- Airborne allergens
- Viral respiratory infections (RSV, non-RSV bronchiolitis, Parainfluenza virus)
- Tobacco smoke
- Air pollution
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Term
| Clinical Presentation of Asthma |
|
Definition
1. Symptoms
- Recurrent cough/Nighttime cough
- Wheezing
- SOB
- Chest tightness
- Decreased exercise tolerance
- Sputum production
2. FH/SH
- Asthma
- Atopic disease (allergic rhinitis, dermatitis, conjunctivitis)
- Home characteristics (cockroaches, mites, pets)
- Smoking
- Workplace or school characteristics
- Educational level
- Employment
- Social support
3. Physical Exam
- Tachypnea, tachycardia
- Atopy, diaphoresis
- Wheezes, accessory muscle use
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Term
| Nonpharmacological Therapy for Asthma |
|
Definition
- Environmental Control
- Manage comorbid conditions
- Self-Management Skills
- Education
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|
Term
| Exercise-Induced Bronchospasm is diagnosed as: |
|
Definition
- 10-15% decrease in PEF or FEV1
- No limit in participation/success in activities
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|
Term
| Pharmacologic Control: Long Term Therapy |
|
Definition
1. Anti-Inflammatory
- inhaled corticosteroids
- mast cell stabilizers
- leukotriene modifiers
- immunomodulators
2. Bronchodilators
- long-acting beta2 agonist
- theophylline
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|
|
Term
| Pharmacologic Control: Quick Relief Therapy |
|
Definition
- short-acting beta2 agonists
- systemic corticosteroids
- anticholinergic agents
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|
|
Term
| First-Line Therapy for Acute Relief of Asthma and Exercise-Induced Bronchospasm |
|
Definition
| Short-Acting Beta2 Agonists |
|
|
Term
| Duration of Action for Short-Acting Beta2 Agonists |
|
Definition
|
|
Term
| Examples of Short-Acting Beta2 Agonists |
|
Definition
- Albuterol
- Levalbuterol
- Pirbuterol
- Terbutaline
|
|
|
Term
| Preferred Therapy for Moderate-Severe Asthma along with ICS |
|
Definition
| Long-Acting Beta2 Agonists |
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|
Term
| Long-Acting Beta2 Agonists are monotherapy or combo-therapy? |
|
Definition
NOT indicated for monotherapy
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|
|
Term
| Long-Acting Beta2 Agonists: Duration of Action |
|
Definition
|
|
Term
| Long-Acting Beta2 Agonists: Examples |
|
Definition
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|
Term
|
Definition
- Hypotension
- Cardiac arrhythmias
- Seizures
|
|
|
Term
| Leukotrienes Modifiers: ADRs |
|
Definition
- Hepatic dysfunction
- Headache
- Abdominal pain
|
|
|
Term
| When should Omalizumab be considered for asthma treatment? |
|
Definition
| Severe persistent allergic asthma in patients > 12 yrs |
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