Term
| Levothyroxine + Multivitamin (iron/calcium) |
|
Definition
| Decreased absorption of thyroid hormone due to chelation |
|
|
Term
| Divalproex Delayed Release + Antacid |
|
Definition
| Dissolved enteric coating of Depakote becomes Valproic acid (immediated release) = Increased GI distress |
|
|
Term
|
Definition
| 50% increase in absorption |
|
|
Term
|
Definition
| 40% increase in absorption |
|
|
Term
|
Definition
| Drinking water or eating food 2-5 min after administration decreases asenapine exposure by 10-20% |
|
|
Term
|
Definition
Valproate displaces phenytoin from plasma protein binding sites
↓
Increased free levels (unbound) of phenytoin
↓
Increased risk for phenytoin toxicity (nystagmus, unstable gait, nausea, sedation, tremor) |
|
|
Term
|
Definition
Aspirin displaces valproate from plasma protein binding sites
↓
Increased free levels (unbound) of valproate
↓
Increased risk for valproate toxicity (nausea/vomiting, tremor, confusion, incoordination) |
|
|
Term
| Warfarin: Metabolism of Enantiomers |
|
Definition
S-Warfarin --> metabolized by CYP2C9
R-Warfarin --> metabolized by CYP3A4/CYP1A2 |
|
|
Term
|
Definition
- Carbamazepine
- Phenobarbital
- Phenytoin
- Primidone
- Rifampin
- St. John's Wort
|
|
|
Term
|
Definition
- Amiodarone
- Cimetidine
- Ciprofloxacin
- Fluvoxamine
- Fluoxetine
|
|
|
Term
|
Definition
- Carbamazepine
- Phenobarbital
- Phenytoin
- Primidone
- Rifampin
- Smoking (polycyclic aromatic hydrocarbons)
|
|
|
Term
|
Definition
- Amiodarone
- Cimetidine
- Fluoxetine
- Paroxetine
- Quinidine
- Ritonavir
- Terbinafine
|
|
|
Term
|
Definition
- Amiodarone
- Fluconazole
- Fluoxetine
- Fluvoxamine
- Isoniazid
- Metronidazole
- Ritonavir
- Trimethoprim/Sulfamethoxazole
|
|
|
Term
|
Definition
- Carbamazepine
- Phenobarbital
- Phenytoin
- Rifampin
|
|
|
Term
| CYP1A2 Antipsychotic Substrates |
|
Definition
- Olanzapine
- Clozapine
- Haloperidol
- Asenapine
|
|
|
Term
| CYP2D6 Antipsychotic Substrates |
|
Definition
- Risperidone
- Clozapine
- Olanzapine
- Aripiprazole
- Iloperidone
- Fluphenazine
- Haloperidol
- Perphenazine
- Thioridazine
|
|
|
Term
| CYP3A4 Antipsychotic Substrates |
|
Definition
- Clozapine
- Quetiapine
- Aripiprazole
- Ziprasidone
- Iloperidone
- Chlorpromazine
- Haloperidol
|
|
|
Term
| Alprazolam + St. John's Wort |
|
Definition
- CYP3A4 induction reaction
- Decreased alprazolam blood levels
|
|
|
Term
| Ethinyl Estradiol + Carbamazepine |
|
Definition
- CYP3A4 Induction Interactions
- Decreased estrogen hormone blood levels (breakthrough bleeding, unintended pregnancy)
|
|
|
Term
| Olanzapine or Clozapine + Cigarette Smoking |
|
Definition
- CYP1A2 Induction Interaction
- Decreased olanzapine or clozapine blood levels
|
|
|
Term
| Fluoxetine/Paroxetine + Risperidone |
|
Definition
- CYP2D6 inhibition interactions
- Increase in risperidone blood levels
|
|
|
Term
|
Definition
- CYP1A2 inhibition interaction
- Increased olanzapine blood levels
|
|
|
Term
| Fluoxetine/Paroxetine + Metoprolol |
|
Definition
- CYP2D6 inhibition interaction
- Increased Metoprolol blood levels
|
|
|
Term
|
Definition
- CYP3A4 inhibition interaction
- Increased Simvastatin blood levels
|
|
|
Term
| Grapefruit Juice Interactions |
|
Definition
- HMG-CoA Reductase Inhibitors
- Buspirone
|
|
|
Term
|
Definition
| Increased lithium blood level up to 50% |
|
|
Term
| Lithium + Diuretics (HCTZ) |
|
Definition
- Increased lithium blood levels by 50%
- Diuretics result in Na+ depletion which causes an increase in renal reabsorption of lithium
|
|
|
Term
|
Definition
- Increased lithium levels by up to 300%
- Volume depletion = decreased lithium excretion through kidneys
|
|
|
Term
| Lithium + Caffeine or Theophylline |
|
Definition
| Decreased lithium blood levels by increasing renal clearance of lithium by ~20% |
|
|
Term
| Quetiapine + diphenhydramine |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Olanzapine/Clozapine + Benztropine |
|
Definition
|
|
Term
| Amitriptyline + Diphenhydramie |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Chlorpromazine + Risperidone |
|
Definition
|
|
Term
|
Definition
| Inhibition of serotonin uptake by platelets = increased bleeding risk |
|
|
Term
| Ziprasidone/Haloperidol/Thioridazine + TCAs |
|
Definition
| Synergistic QTc prolongation |
|
|
Term
| Carbamazepine + Clozapine |
|
Definition
|
|
Term
| Benzodiazepines + Other Sedative-Hypnotics |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Lowered Seizure Threshold |
|
|
Term
|
Definition
| Lowered Seizure Threshold |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Fluoxetine + Pseudoephedrine |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Carbamazepine + Valproic Acid |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Valproic Acid + Bupropion |
|
Definition
|
|
