Term
| What is the primary site of Hodkin's Lymphoma? |
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Definition
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Term
| What are sites of Non Hodgkin's Lymphoma? |
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Definition
| Extranodal disease in stomach, skin, oral cavity, and pharynx |
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Term
| What are four types of Classic Hodkin's Lymphoma? |
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Definition
| Nodular sclerosis, Lymphocyte predominant/rich, Mixed cellularity, Lymphocyte depleted |
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Term
| What are symptoms of Hodkin's Lymphoma? |
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Definition
| Fever, night sweats, weight loss, malaise, bone pain. |
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Term
| What will lab findings of Hodkin's Lymphoma be? |
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Definition
Anaemia, raised ESR, eosinophilia
Advanced stage: lymphopenia |
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Term
| What is Cotwold's Modification system? |
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Definition
I: single lymph or lymphoid
II: 2 or more on same side of diaphram
III: both sides of diaphram
IV: extranodal sites proximal to nodal site
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Term
| How is stage I or II lymphoma managed? |
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Definition
Chemo + radiation
(ABVD): Adriamycin/Doxorubicin, Bleomycin, Vinblastine, Dacarbazine (2-4 cycles)
IFRT: involved field radiotherapy (20-30Gy) |
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Term
| How is advanved (stage III and IV) treated? |
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Definition
6-8 cycles of ABVD, IFRT if required
Relapse: more ABVD, but maybe BEACOPP or Stanford V |
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Term
| What is the ABVD treatment? |
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Definition
Adriamycin/Doxorubicin, Bleomycin, Vinblastine, Dacarbazine
30 day cycles (days 1 & 15) |
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Term
| What is the BEACOPP 14 regiem? |
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Definition
| Bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine, prednisolone (14 day cycle) |
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Term
| What is the Stanford V (28 day cycle) |
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Definition
| Mustine, Doxorubicin, Vinblastine, Predinisolone, Vincristine, Bleomycin, Etoposide |
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Term
| What is are new agents used in relapsed Hodkin's Lymphoma? |
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Definition
Gemcitabine (classic)
Bortezomib: proteosome inhibitor |
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Term
| What is Rituximab? What is it used for? |
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Definition
anti-CD20 antibody;
Nodular lymphocyte predominant Hodkin's lymphoma |
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Term
| Apart from Stanford V and BEACOPP, what other chemo regimens are used in case of relapsed HL? |
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Definition
DHAP: Cisplatin, Cytarabine, Dexamethasone
ESHAP: Etoposide, Me.Prednisolone, Cytarabine, Cisplatin
ICE: Ifosfamide, Carboplatin, Etoposide |
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Term
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Definition
Ifosfamide, Carboplatin, Etoposide
Salvage chemotherapy |
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Term
| What is first-line drug in Non Hodgkin's Lymphoma? |
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Definition
| Chlorambucil (alkylating agent) |
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Term
| What is used to treat aggresive NHL stages II-IV? |
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Definition
CHOP (cyclophosphamide, hydroxydaunorubicin, vincristine, prednisolone) + rituximab
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Term
| Which chemo drug requires an appropriate mouthcare regimen to counter the adverse effect mucositis? |
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Definition
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Term
| Which chemo drugs cause alopecia? |
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Definition
| Cyclophosphamide, doxorubicin, etoposide |
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Term
| Which chem is known to cause lung fibrosis? |
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Definition
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