Term
| Etiology of Anemia: Deficiency |
|
Definition
- Iron
- vit B12
- Folic Acid
- Pyridoxine
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Term
| Etiology of Anemia: Central |
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Definition
- Anemia of Chronic Disease
- Malignancy
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Term
| Etiology of Anemia: Peripheral |
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Definition
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Term
| Classification of Anemias Based on Morphology: Macrocytic |
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Definition
- Vit B12 Def.
- Folic Acid Def.
- Alcoholism
- Liver Disease
- Myelodysplasia
- Hypothyroidism
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Term
| Classification of Anemias Based on Morphology: Microcytic |
|
Definition
- Iron Deficiency
- Sickle Cell
- Thalassemia
- Hemoglobinopathies
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Term
| Classification of Anemias Based on Morphology: Normocytic |
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Definition
- Blood loss
- Hemolysis
- Bone Marrow d/o
- Anemia of Chronic Disease
- Renal Failure
- Endocrine d/o
- Myeloplastic anemias
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Term
| Symptoms of Iron Deficiency |
|
Definition
- Glossal pain
- Smooth tongue
- Reduced salivary flow
- Pica
- Pagophagia
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Term
| Symptoms of B12 Deficiency |
|
Definition
- Pale
- Icteric
- Numbness
- Paresthesias
- Peripheral neuropathy
- Ataxia
- Decreased vibratory sense
- Decreased DTR
- Irritability
- Memory impairment
- Dementia
- Depression
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Term
| Symptoms of Folic Acid Deficiency |
|
Definition
- Similar to B12 def.
- No neuro symptoms
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Term
| If someone has decreased Hct, you would expect to see: |
|
Definition
- Reduced number of RBCs
- Reduced size of RBCs
- Increased plasma volume
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Term
| Hematocrit is defined as: |
|
Definition
| The actual volume of RBCs in a unit volume of whole blood |
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Term
| A patient would have falsely elevated MCV if: |
|
Definition
- they have reticulocytosis (cells are larger)
- hyperglycemia
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Term
| Mean Corpuscular Hemoglobin is defined as: |
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Definition
| the percent of Hgb in an RBC |
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Term
| Total Iron Binding Capacity is defined as: |
|
Definition
| The indirect measure of iron binding capacity of transferrin |
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Term
| Low Fe + High TIBC indicates |
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Definition
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Term
| Low Fe + Low TIBC indicates |
|
Definition
| Anemia of Chronic Disease |
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Term
| TIBC may be elevated with: |
|
Definition
- Oral contraceptive use
- Pregnancy
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Term
| Schilling Test is used for: |
|
Definition
| Diagnosing B12 Def. Anemia |
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Term
| What test is used to differentiate between B12 def and Folic Acid def anemia? |
|
Definition
Methylmalonic acid
High MMA is diagnostic for B12 anemia but not affected by FA def |
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Term
| A positive direct Coombs test (or direct antiglobulin test) is indicative of: |
|
Definition
| antibody-mediated or autoimmune hemolysis |
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Term
| Treatment of IDA: Pharm and Nonpharm |
|
Definition
- Dietary supplementation and iron preparations (meat, fish, poultry best)
- Recommend meat, orange juice, and other high iron and ascorbic acid containing foods
- 200 mg of elemental iron daily in 2-3 divided doses (titrate up to improve tolerability)
- Continue treatment for 3-6 months after resolution to allow for repletion of iron stores
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Term
| Oral Iron Preparations: ADRs |
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Definition
- Dark discoloration of feces
- Constipation or diarrhea
- Nausea
- Vomiting
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Term
| Drugs that decrease Iron Absorption |
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Definition
- Aluminum, Magnesium, Calcium containing antacids
- Tetracycline and doxycycline
- H2 antagonists
- Proton pump inhibitors
- Cholestyramine
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Term
|
Definition
- Decreases levodopa
- Decreases methyldopa
- Decreases levothyroxine
- Penicillamine
- Fluoroquinolones
- Tetracyclines and doxycycline
- Mycophenolate
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