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Theophylline PK
worksheet
7
Pharmacology
Professional
12/08/2012

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Term
What is salt factor?
Definition
Aminophylline contains 80% theophylline - S = 0.8
Term
What is the therapeutic range for theophylline?
Definition
5-15 mcg/mL
Term
How is Vd found for theophylline?
Definition
Vd = 0.5 L/kg --> Multiply by weight
**Use actual body weight
Term
What CYP450 enzymes affect theophylline?
Definition
1A2 and 3A4
- Inhibitors - cimetidine, cipro, erythro, propranolol, flu vaccine
- Inducers - phenytoin, phenobarb, rifampin. Smoking, CF
Term
How is clearance found given Vd and an initial MD/loading dose?
Definition
Rearrange the loading dose formula: C = Dose / Vd
** To find a different dose based on Vd, rearrange to: Dose = C * Vd
Term
How would loading dose be determined given weight and a goal concentration?
Definition
Remember C = Dose/V and S = 0.8 --> Dose = C * Vd/0.8
**If patient has a starting concentration, than (Cdesired - Cstart)
Term
How can theophylline clearance be estimated given weight?
Definition
Remember Vd = 0.5 * weight in Kg
and Cl = 0.04 L/kg/hr --> multiply 0.04 * weight in kg
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