Term
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Definition
| Aminophylline contains 80% theophylline - S = 0.8 |
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Term
| What is the therapeutic range for theophylline? |
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Definition
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Term
| How is Vd found for theophylline? |
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Definition
Vd = 0.5 L/kg --> Multiply by weight
**Use actual body weight |
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Term
| What CYP450 enzymes affect theophylline? |
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Definition
1A2 and 3A4
- Inhibitors - cimetidine, cipro, erythro, propranolol, flu vaccine
- Inducers - phenytoin, phenobarb, rifampin. Smoking, CF |
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Term
| How is clearance found given Vd and an initial MD/loading dose? |
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Definition
Rearrange the loading dose formula: C = Dose / Vd
** To find a different dose based on Vd, rearrange to: Dose = C * Vd |
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Term
| How would loading dose be determined given weight and a goal concentration? |
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Definition
Remember C = Dose/V and S = 0.8 --> Dose = C * Vd/0.8
**If patient has a starting concentration, than (Cdesired - Cstart) |
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Term
| How can theophylline clearance be estimated given weight? |
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Definition
Remember Vd = 0.5 * weight in Kg
and Cl = 0.04 L/kg/hr --> multiply 0.04 * weight in kg |
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