Term
| What are the three categories of erythrocytosis? |
|
Definition
1) relative polycythemia
2) secondary polycythemia
3) primary polycythemia or polycytemia vera |
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Term
| Hematocrit levels in men and women categorized as increased RBC mass? |
|
Definition
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|
Term
| epidemiology associated with relative polycythemia? |
|
Definition
| obese, hypertensive men, 45-55 yo |
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|
Term
| High affinity hemoglobin is caused by what? |
|
Definition
| an amino acid substitution in the b chain of globin which impedes oxygen unloading |
|
|
Term
| what are 6 things that cause secondary polycythemia? |
|
Definition
1) Life at high altitude
2) High affinity hemoglobin
3) cardiopulmonary disease
4) obesity-hypoventilation syndrome
5) obstructive sleep apnea
6) High carboxyhemoglobin levels |
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Term
| what Px finding is seen in 70% of patients with polycythemia vera and why?/ |
|
Definition
| splenomegaly from extramedullary hematopoesis |
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Term
| phlebotomy recommendations for polythycemia vera? |
|
Definition
| removal of 500cc 1-2x a week until hct is <45% |
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Term
| how does anagrelide work and what is it used for? |
|
Definition
| it inhibits megakaryocyte maturation and decreases platelet count |
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|
Term
| What is the most effective myelosuppressive agent for polycythemia vera? |
|
Definition
|
|
Term
| What is the most common complication of polycythemia vera? |
|
Definition
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