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The Blood
Platelets and Clotting
17
Physiology
Undergraduate 2
09/21/2010

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Cards

Term
cell fragments circulate for
__/___ circulate, rest reside in?
Definition
5-9 days then die
2/3 ; spleen
Term
thrombis
thrombosis
embolus
Definition
a clot
clot formation
circluationg clot
Term
thrombocytopoiesis
Definition
myeloid stem cells produce megakaryocytes
Term
series of 3 reactions to stop bleeding
Definition
vascular spasm
platelet plug formation
coagulation
Term
vascular spasm occurs only in
Definition
arterioles
Term
capillaries have no _______ so no ________ ____________
Definition
smooth muscle; vascular spasm
Term
vascular spasm works by
contraction of
Definition
pressing endothelial cells together
smooth muscle that lines blood vessel(spontaneous)
Term
platelets do/do not normally stick to eachother
Definition
do not
Term
when blood vessel damaged, platelets stick to
3 chemicals activated that attract and create more platelets
Definition
exposed collagen fibers
thromboxane a2, serotonin(vasoconstriction), ADP(sticky platelets)
Term
Coagulation
Definition
set of reactions when blood is transformed from a liquid to a gel
Term
Final 3 steps of coagulation
Definition
Prothrombin activator is formed

Prothrombin is converted into thrombin

Thrombin catalyzes the joining of fibrinogen into a fibrin mesh
Term
Thrombins main functions(2)
Definition

Converts fibrinogen (soluble) to fibrin (insoluble, stable threads)

Activates factor XIII, which stabilizes the fibrin network
Term
Clotting factors synthesized in liver
Definition
clotting factor 5 7 9 and 10 as wel as prothrombin and fibrinogen
Term
vitamin k deficiency can lead to ? since its needed to synthesize factors ?(4)
Definition
problems clotting blood
2, 7,9 ,10
Term
hemophiliacs lack
Definition
factor 8
Term
Fibrinolysis
Definition
dissolution of a clot so that it does not become an embolus
Term
which 3 chemicals react to form plasmin?
plasmin digests __________ strands and digests the clot
Definition
thrombin, plasminogen, tissue plasminogen activator.
fibrin
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