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The Blood
Platelets and Clotting
17
Physiology
Undergraduate 2
09/21/2010

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Cards

Term
cell fragments circulate for
__/___ circulate, rest reside in?
Definition
5-9 days then die
2/3 ; spleen
Term
thrombis
thrombosis
embolus
Definition
a clot
clot formation
circluationg clot
Term
thrombocytopoiesis
Definition
myeloid stem cells produce megakaryocytes
Term
series of 3 reactions to stop bleeding
Definition
vascular spasm
platelet plug formation
coagulation
Term
vascular spasm occurs only in
Definition
arterioles
Term
capillaries have no _______ so no ________ ____________
Definition
smooth muscle; vascular spasm
Term
vascular spasm works by
contraction of
Definition
pressing endothelial cells together
smooth muscle that lines blood vessel(spontaneous)
Term
platelets do/do not normally stick to eachother
Definition
do not
Term
when blood vessel damaged, platelets stick to
3 chemicals activated that attract and create more platelets
Definition
exposed collagen fibers
thromboxane a2, serotonin(vasoconstriction), ADP(sticky platelets)
Term
Coagulation
Definition
set of reactions when blood is transformed from a liquid to a gel
Term
Final 3 steps of coagulation
Definition
Prothrombin activator is formed
–
Prothrombin is converted into thrombin
–
Thrombin catalyzes the joining of fibrinogen into a fibrin mesh
Term
Thrombins main functions(2)
Definition
–
Converts fibrinogen (soluble) to fibrin (insoluble, stable threads)
–
Activates factor XIII, which stabilizes the fibrin network
Term
Clotting factors synthesized in liver
Definition
clotting factor 5 7 9 and 10 as wel as prothrombin and fibrinogen
Term
vitamin k deficiency can lead to ? since its needed to synthesize factors ?(4)
Definition
problems clotting blood
2, 7,9 ,10
Term
hemophiliacs lack
Definition
factor 8
Term
Fibrinolysis
Definition
dissolution of a clot so that it does not become an embolus
Term
which 3 chemicals react to form plasmin?
plasmin digests __________ strands and digests the clot
Definition
thrombin, plasminogen, tissue plasminogen activator.
fibrin
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