Term
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Definition
| What Adverse Effect does Tetracylcine, Macrolids, and Aminoglycosidases all have in common |
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Term
| blocks amino acyl charged tRNA for 30S ribosome inhibition |
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Definition
| Tetracycline site of action |
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Term
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Definition
| Structure of tetracyclines |
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Term
Broad Specturm: Aerobic, Anearobic, G +, and G-
Can produce C. difficile superinfection |
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Definition
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Term
| H. pylori(GI ulcers) and Acne |
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Definition
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Term
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Definition
| Half Life of tetracycline |
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Term
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Definition
| Half Life of Demedocycline |
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Term
| Tetracycline, Demedocycline, Doxycycline, Minocycline, Tigercycline |
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Definition
| Tetracycline antibiotics (5) |
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Term
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Definition
| Half life of doxycycline and minocycline |
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Term
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Definition
| Most widely prescribed Tetracycline |
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Term
Rickettsia (RMSF and typhus)
Chlamydia psittao
Chlamydia trachomatis (lymphagranuloma venereum)
Ureaplasma urealyticum (urethritis)
M. Pneumonia - Atypical Pneumonia
Borrelia granulnatis - granuloma inguinale |
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Definition
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Term
Cholera
Brucellosis
Chlamydia pneumo |
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Definition
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Term
Legionella pneumo (Azithromycin)
H. dureyi - chancroid
C. tetani - tetanus(Vancomycin)
C. perfrin - Gas gangrene (PNCG)
syphilis (PNC G ) |
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Definition
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Term
Nocardia (pulmonary)
Neisseria meningitis (carrier)- elimination in carrier state since its in saliva and tears
Acne |
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Definition
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Term
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Definition
| Half Life of Tigercycline (Glycylcycline) |
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Term
MRSA
MRSE
VISA
VRSA
Pen resistant Strep Pneumo
VRE |
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Definition
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Term
| Skin infections, complicated intra-abdominal, and community required pneumonia |
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Definition
| Indications for Tigercycline |
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Term
Decreased accumulation-increased efflux
Alteration of target
Enzymatic inactivity |
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Definition
| Resistant Mechanisms of Tetracyclines |
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Term
| Doxycycline and Minocycline |
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Definition
| oral available tetracyclines |
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Term
| Dairy, Antacids, Ca 2+, Magnesium, aluminum, iron. Due to divalent and trivalent bonds decreasing absorption |
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Definition
| What types of food should be avoided with tetracyclines |
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Term
| Kidney, Liver, Spleen, Skin |
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Definition
| Distribution of Tetracyclines |
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Term
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Definition
| Tetracycline of choice for renal failure |
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Term
Accumulate in the liver
Secreted into bile
Reabsored by intestine and excreted into glomerular filtration |
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Definition
| Metabolism of Tetracyclines |
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Term
Pregnant
Breast Feeding
Children less than 8 yo
Impaired Liver function |
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Definition
| Contraindications of Tetracyclines |
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Term
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Definition
| Outdated tetracyclines cause |
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Term
Children and Fetus- discoloration of teeth
Phototoxicity - everyone except minocycline
Vestibular Problems (minocycline)
Superinfection (C. difficil)
Fanconi
Pseudotumor cerebri
GI |
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Definition
| Major Adverse Sides of tetracyclines |
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Term
| Irreversible inhibition of 30S subunit (misreading of mRNA) |
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Definition
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Term
| Anearobes- need oxygen dependent system for transport across cell membrane |
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Definition
| What can't Amynoglycosides kill |
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Term
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Definition
| Amynoglycosides are synergistic with |
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Term
| Y. pestis and F. tularemsis |
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Definition
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Term
Brucella
Streptobacillus
Myco tuberculosis |
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Definition
| 2nd line for streptomycin |
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Term
GNATS K
Gentamycin
Neomycin
Amikacin
Tobramycin
Streptomycin
Kanamycin |
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Definition
| Types of Aminoglycosidases |
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Term
Gram negative
Severe: Bacteremia, Endocarditis (HACEK and Viridans Strep), Meningitis, Pneumonia, Chronic UTIs(Ecoli, Enterobacter, Pseudomonas, Proteus, Klesiella, Serratia) |
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Definition
| Gentamycin and Tobramycin used for what physical conditions: |
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Term
Strep agalactiae
Lysteria
Campy fetus
Brucella |
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Definition
| 1st Line drug for Tobramycin and Gentamycin: |
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Term
| Staph or strep epidermis infections |
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Definition
| Gentamycin should not be used solely for |
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Term
|
Definition
| Broadest Aminoglycosidase spectrum |
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Term
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Definition
| Aminoglycosidase which is resistant to inactive enzymes |
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Term
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Definition
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Term
Skin (Neosporin) which if there is a reaction it is from the Neomycin.
Bowel Surgery: Bowel sterilization and hepatic coma |
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Definition
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Term
| Serratia and P. aeriginosa |
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Definition
| Kanamycin should not be used for |
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Term
| Surgical prophylaxis via irragation |
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Definition
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Term
|
Definition
| Killing occurs below MIC in Aminoglycosidase |
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Term
| Sterptococcus and Enterococcus |
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Definition
| Aminoglycosidases are used with cell wall inhibitors (vancomycin and beta lactams) for: |
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Term
|
Definition
| Administration of Aminoglycosidases |
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Term
renal cortex and Inner Ear
Traverse placental barrier - teratogenic |
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Definition
| Distribution of Aminoglycosidases |
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Term
| They are not metabolized but are rapidly excreted by Glomerular filtrate and accumulates in renal failure |
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Definition
| Metabolism of Aminoglycosidases |
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Term
Ototoxic, Nephrotoxic (increased by loop diuretics), Neuromuscular Paralysis (neomycin), Allergies, Optic (streptomycin), Teratogen
Most problems are with Neomycin |
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Definition
| Adverse Sides of Aminoglycosidases |
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Term
| 50S ribosome, inhibiting amino acyl tranlocation rxn of peptidyl RNA. |
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Definition
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Term
Both Low dose (Bacteriostatic)
High dose (Bactericidal) |
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Definition
| Macrolids (Bactericidal or Bacteriostatic)? |
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Term
| Erythromycin, Clarithromycin, Azithromycin |
|
Definition
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Term
Corynebacterium diptheria
H. ducreyi |
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Definition
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Term
| beta lactams- treats similar microbes as penicillin G |
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Definition
| Ezythromycin is an alternative for allergic rxns too |
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Term
MAI complex
Chlamydia pneumonia
Corynebacterium dipth |
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Definition
| 1st line of Clarithromycin |
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Term
| Taxoplasma Gondii, Cryptosporidium, Plasmodium |
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Definition
| Clarithromycin and Azythromycin can be used against what protozoa |
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Term
|
Definition
| Most Widely prescribed Macrolid |
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Term
|
Definition
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Term
Legionella and Chlamydia Pneumo
Corynebacterium diptheria |
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Definition
| 1st line for Azythromycin |
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Term
| Azythromycin (also Morexella catarrhal)>Clarithromycin>Erythromycin |
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Definition
| Best Macrolids against H. flu |
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|
Term
1. alter 50S subunit
2. Inactivation associated esterase
3. decrease permeabilty or increase efflux
4. cross resistance btw macrolids
5. methylation of 23s rRNA |
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Definition
| Resistance against Macrolids |
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Term
| Clarithromycin and Azithromycin stable in gastric acid, All can be taken Orally, Food decrease Azithromycin and Erythromycin but increases clarithromycin |
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Definition
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Term
| Hepatic excretion in bile and feces |
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Definition
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Term
| Hepatic excretion in bile and feces, P450 system. Reabsorbed enterohepatic. |
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Definition
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Term
1st pass oxidation to 14-hydroxy metabolite
Excreted by both the kidney and liver |
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Definition
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Term
Epigastric and GI, Ototoxic, Cardiotoxicity (Erythromycin)
Hepatic Damage (Erythromycin and Azithromycin)
Renal Damage (Clarithromycin) |
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Definition
| Major Adverse Sides of Macrolids |
|
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Term
| theophylline, warfarin, carbamyzepin, cyclosporine |
|
Definition
| Erythromycin and Clarithromycin Drug Interactions |
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Term
|
Definition
| Which drug does not inhibit CYP3A4 of the Macrolids |
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Term
|
Definition
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Term
Respiratory tract infections
staph aureus
Strep pyogenes/pneumonia (MDRSP)
H flu
Morexella catarhals
Legionella
Mycoplasma pneumonia
Chlamydia pneumonia |
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Definition
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|
Term
| Oral with intracellular penetration |
|
Definition
| Administration of Telithromycin |
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Term
| Hepatic, eliminated in kidney and some urine/bile |
|
Definition
| Metabolism of Telithromycin |
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Term
| Cholestatic jaundice and hepatic failure |
|
Definition
| Adverse Sides of Telithromycin |
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Term
Patient less than 18
Hepatic problems
Patients with prolonged QT |
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Definition
| Contraindication of Telithromycin |
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Term
| Multidrug (2 of Penicillin, 2nd gen cyclosporines, macrolids, tetracyclines, bactrin (SMX-TAP)) resistant sterp Pneumo |
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Definition
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|
Term
| Inhibits protein synthesis by blocking translocation in 50S. It binds to 2 binding sites instead of 1 (5 and 2) |
|
Definition
|
|
Term
|
Definition
| All Gram + cocci are resistant to... |
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Term
| Tobramycin/cftazidime/cefepime |
|
Definition
| Combination treatment for P. aeruginosis |
|
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Term
| Otitis Media due to it not covering H. flu |
|
Definition
| Ezythromycin not a good choice for |
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Term
| Bacellis Anthrax, MRSA, L. monocytogenes, actinomyces israelli |
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Definition
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Term
H. flu
Strep and staph increased
Intracellular: Chlamydia, legionella, mycobacteria, ureaplasma |
|
Definition
| Clarithromycin is more effective against what when compared to Erythromycin |
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Term
|
Definition
| Best Macrolid for G- UTIs |
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