Broad spectrum static for G+/- and some intracellular organisms

lipid soluble

enterohepatic recylcing

Mechanism: inhibits binding of aminoacyl tRNAto acceptor site

short acting (half-life 6-8hrs)

for acne

Intermediate acting (half-life 12 hours)

used to treat chronic dilutional hyponatremia in the syndrome of inappropriate ADH (SIADH) - inhibits protein kinase in ducts on which ADH depends

long acting (1/2 life - 16-18 hours) - highly lipophilic

oral & IV

95% absorbed

significant excretion in feces

long acting (1/2 life - 16-18 hours) - highly lipophilic

treat acne but assoociated with pulmonary complications

• anti-inflammatory - blocks NO and activation of microglia (these are associated with inflammation)
• decreased neuronal damage (good for stroke victims)
• might be neuroprotective for degenerative diseases
• reports of SLE like symptoms (goes away with d/c)
• can cause nail, skin, & sclera pigmentation

Side effects for tetracyclines

• upset GI - take with food
• slowed growth
• brown discoloration of teeth (permanent)
• photosensitivity (especially demeclocycline)
• Expired Rx - Fanconi Like Syndrome (nephrotoxic product)
• Absorption of all tetracyclines is decreased with dairy products and antacids (chelation, combines with Ca and gets excreted)
  

parenteral, long acting derivative of minocycline with similar side effects

greater activity vs tetracycline-sensitive G+/- and MRSA.

Used for complicated skin and intraabdominal infections