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Test 8
Respiration Slides
91
Physiology
Professional
12/15/2010

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Cards

Term
Describe the pleural sac
Definition
double walled, fluid filled, visceral pleura is closest to lung, parietal pleura is closest to thoracic wall
Term
Describe trachea and larger bronchi
Definition
rigid, nonmuscular tube. C-shaped cartilage to prevent collapse
Term
describe alveoli
Definition
thin-walled inflatable sacs, consisting of a single layer of Type 1 alveolar cells
Term
what are alveoli surrounded by?
Definition
pulmonary capillaries
Term
Out of the three important pressures in ventilation, which is always the lowest?
Definition
intrapleural pressure
Term
what is pneumothorax?
Definition
collection of air in the pleural cavity-puts pressure on the lungs
Term
what is hemothorax?
Definition
collection of blood in the pleural cavity-puts pressure on mediastinum/trachea/heart ventricles
Term
name pressure conditions for air to enter the lungs
Definition
intra-alveolar pressure is less than atmostpheric pressure
Term
percentage of body's energy used to inspire?
Definition
3%
Term
major muscles of inspiration
Definition
diaphragm (phrenic nerve) and external intercostal muscles (intercostal nerve)
Term
when the diaphragm contracts, what happens to it, lungs, and pressure?
Definition
diaphragm lowers, thoracic cavity expands, lungs expand which causes the pressure to decrease below atmostpheric pressure and air enters lung
Term
Pulmonary fibrosis ______ compliance
Definition
decreases
Term
Effect on bronchioles of parasympathetic stimulation?
Definition
bronchoconstriction
Term
effects on bronchioles of sympathetic stimulation?
Definition
bronchodilation
Term
If there are high levels of CO2, what happens to bronchioles?
Definition
bronchodilation
Term
if there are low levels of CO2, what happens to bronchioles?
Definition
bronchoconstriction
Term
epinephrine's effects on bronchioles?
Definition
bronchodilation
Term
what happens to the volume of the chest cavity during expiration
Definition
decreases
Term
what happens to the inrapleural pressure during expiration?
Definition
increases (muscles are relaxation -coming in -so puts pressure on the cavity)
Term
what happens to intra-alveolar pressure during expiration
Definition
increases
Term
when intra-alveolar pressure exceeds atmospheric pressure, what happens?
Definition
air is forced out = expiration
Term
what are the expiratory muscles?
Definition
diaphragm and internal intercostal muscles
Term
what is forced expiration?
Definition
contraction of expiratory muscles (diaphragm and internal intercostal muscles)
Term
What 2 factors does elastic recoil depend on?
Definition
elastic CT in lungs
Alveolar surface tension
Term
what causes alveolar surface tension?
Definition
a thin liquid film lines each alveolus
Term
what are the effects of alveolar surface tension?
Definition
reduces tendency for alveoli to expand (minimizes size)
Term
emphysema?
Definition
loss of elastic tissue (esp alveoli) alveoli walls collapse--barrel chest
Term
what happens in COPD
Definition
difficult expiring>>forced expiration>>airways collapse>>air trapped in lungs>>barrel chest
Term
During quiet normal breathing (expiration), describe intrapleural and intra-alveolar pressures
Definition
Intrapleural: lower than intra-alveolar
Intra-alveolar: slightly higher than atmosphereic and higher than intra-pleural
Term
During expiration, describe pressure during exercise
Definition
intrapleural: elevated
intra-alveolar: elevated and slightly above intra-pleural
Term
During expiration, describe pressures during maximal forced expiration:
Definition
intrapleural: very elevated
intra-alveolar:very elevated-slightly higher than intrapleural

**narrow airways
Term
during expiration, describe pressures in patients with obstructive lung disease
Definition
intrapleural: very elevated
intra-alveolar: elevated (higher than intrapleural)--looks the same as if were doing exercise
Term
What is Newborn Respiratory Distress Syndrome?
Definition
insufficiency of surfactant production>>>collapse of alveoli

low compliance>>>have trouble inflating their lungs
Term
what percentage of lung is filled w air during normal breathing?
Definition
half
Term
when elastic coil is decreased (emphysema) what happens
Definition
more work to breathe
Term
what is a spirogram?
Definition
graph that records inspiration and expiration
Term
What is inspiratory reserve volume?
Definition
extra volume of air that can be maximally inspired over the typical tidal volume (3000 mL)
Term
what is expiratory reserve volume?
Definition
volume of air that can be maximally expired after normal tidal volume has been expired (1000 mL)
Term
residual volume
Definition
minimum volume of air leftover after a maximal expiration (1200 mL)
Term
what is functional residual capacity?
Definition
volume of air in lungs after normal passive expiration (2200 mL)

the residual volume + expiratory reserve volume
Term
what is vital capacity?
Definition
MaX Volume of air that can be moved out during a single breath following a maximum inspiration (take tidal volume add to it the IRV then add to that the ERV)
Term
total lung capacity?
Definition
max volume of air the lungs can hold
(vital capacity plus the residual volume)
Term
What is FEV1
Definition
forced expiratory volume in first second in a Vital Capacity determination
Term
what's the normal volume of air in the lungs after inspiration? after expiration?
Definition
2700 and 2200 mL
Term
what is the value of the total lung capacity?
Definition
5700 mL
Term
what is the value of residual volume (minimum amount of air in lungs)
Definition
1200 mL
Term
what does COPD do to Functional Residual capacity?
Definition
increases it (air is left over after you expire bc the airways collapse and ther is air sitll left in alveoli)
Term
what does COPD do to residual volume?
Definition
increases it (can't exhale fully bc air is trapped from collapsed airways)
Term
What does COPD do to vital capacity?
Definition
decreases it (can't exhale enough)
Term
what does COPD do to FEV1?
Definition
significantly reduces it because there's more resistance and air can't be exhaled as much
Term
What does restrictive/less compliant lung do to total lung capacity?
Definition
decreases (can't inhale as much)
Term
What does restrictive/less complaint lung do to vital capacity?
Definition
decreases (can't inhale as much)
Term
what does restrictive/less compliant lung to do FEV1?
Definition
nothing-you don't have problems exhaling and the rate is the same
Term
what is pulmonary ventilation?
Definition
air breathed in and out in one minute
Term
equation for pulmonary ventilation?
Definition
tidal volume x respiratory rate
Term
what are the effects of impaired bulbar muscles?
Definition
aspiration of food particles
Term
what is alveolar ventilation?
Definition
volume of air exchanged between the atmosphere and alveoli per minute
Term
is alveolar ventilation greater or less than pulmonary ventilation?
Definition
less than due to anatomic dead space
Term
what is anatomic dead space?
Definition
volume of air in conducting pathways which is useless for exchange (150 mL)
Term
equation for alveolar ventilation?
Definition
= (tidal volume - dead space) x respiratory rate
Term
Similarity and Difference between quiet breathing at rest and deep slow breathing?
Definition
pulmonary ventilation is the same (taking in the same amount of air)
alveolar ventilation is greater in deep breathing bc you are taking more oxygen in at each breath
Term
similarity and difference between quiet normal breathing and short shallow breathing?
Definition
pulmonary ventilation is the same (amount of air taken in is the same) but alveolar ventilation is much higher in normal breathing bc in short rapid breathing, the oxygen does not reach the respiratory bronchioles
Term
even though CO2 has a lot smaller partial pressure gradient for gas exchange than O2, why are equal amounts of CO2 and O2 exchanged?
Definition
CO2 is much more soluble
Term
what is the main factor in determining hemoglobin saturation?
Definition
partial pressure of oxygen
Term
in an area of low PO2, where does oxygen go?
Definition
dissociates form Hb (tissues)
Term
in an area of high PO2, where does O2 go?
Definition
stays on Hb (lungs)
Term
average Po2 of tissues?
Definition
40 mmHg
Term
the production of BPG does what to oxygen?
Definition
kicks it off of Hb aka moves Oxygen dissociation curve to the right and delivers more oxygen to tissues
Term
what type of CT exists the entire way down the respiratory tract?
Definition
elastic cartilage
Term
what is hypoxia?
Definition
having low oxygen levels at cell level
Term
hypoxic hypoxia
Definition
low O2 levels bc of respiratory issues
Term
anemic hypoxia
Definition
reduced O2 carrying capacity of blood
Term
circulatory hypoxia:
Definition
decreased amount of blood delievered to tissues
Term
histoxic hypoxia:
Definition
cells cannot use own oxygen
Term
what is hyperoxia?
Definition
having above normal O2 in arteroile blood
Term
what is hypercapnia?
Definition
having excess CO2 in arteriole blood
Term
cause of hypercapnia
Definition
hypoventilation
Term
hypocapnia:
Definition
below-normal PCO2 levels
Term
causes of hypocapnia
Definition
hyperventilation
-fever
-anxiety
Term
name 2 respiratory control centers in the brain stem
Definition
pons respiratory centers and medullary respiratory centers
Term
what are the 2 centers in the pons respiratory centers?
Definition
pneumotaxic center and apneustic center
Term
what are the 2 centers in the medullary center?
Definition
dorsal respiratory group and ventral respiratory group
Term
which center generates breathing rhythm
Definition
medulla
Term
which respiratory group is active during normal passive inspiration?
Definition
dorsal respiratory group
Term
which respiratory group is active in active inspiration and esp active respiration?
Definition
ventral respiratory group
Term
what are the pacemaker-like cells
Definition
Pre-Botzinger complex
Term
which centers regulate magnitude of breathing?
Definition
Pons respiratory centers
Term
what does the pneumotaxic center do?
Definition
sends impulses to dorsal regulatory group to turn off inspiratory neurons for smooth breathing
Term
what does the apneustic center do?
Definition
blocks pneumotaxic center
Term
what does the Hering-Breuer reflex do?
Definition
prevents over-inflation of lungs (inhibits DRG when lungs stretch)
Term
what value does PO2 have to be at for peripheral receptors to become sensitive?
Definition
below 60 mmHg
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