Term
|
Definition
1-Lung and bronchus
2-Breast
3-Prostate
4-Colon |
|
|
Term
Malignant tumors
Cure
Prostate Cancer in U.S. |
|
Definition
-Spread to distinct sites(malignant)
-5-year survival rate (about 65%)
-1 in 6 men during their lifetime |
|
|
Term
|
Definition
| Acts on tumor cells that are actively in the cell cycle and not the resting phase |
|
|
Term
|
Definition
| Kills tumor cells in cycling and resting phases of the cell cycle |
|
|
Term
|
Definition
|
|
Term
| Drugs that kill cancer cells follow what order of Kinetics |
|
Definition
| They follow a first order kinetic |
|
|
Term
Drugs that affect the synthesis of DNA
(antimetabolites) (CCS) |
|
Definition
-Methotrexate-Inhibits dihydrofolate reductase
-5-fluorouracil
-mercaptopurine |
|
|
Term
Drugs that affect RNA synthesis (CCNS)
Alkylating agents |
|
Definition
-Cyclophosphamide
-BiCNU
-Cisplatin
-Carboplatin |
|
|
Term
| Hormonal agents and antagonists |
|
Definition
-corticosteroids
-antiestrogen: tamoxifen
-aromatase inhibitors: anastrazole
letrozole |
|
|
Term
| What is the mechanism of axn of antibiotics? |
|
Definition
| Inhibit protein formation |
|
|
Term
| What phase do microtubule inhibitors affect? |
|
Definition
|
|
Term
| Name 3 microtubule inhibitors |
|
Definition
vinblastine
vincristine
paclitaxel-Non-small cell lung cancer and metastastic breast cancer |
|
|
Term
|
Definition
-IM
-Herceptin-for breast cancer |
|
|
Term
| What are 3 cancer drugs that are not classified? |
|
Definition
Elspar
Avastin
Tarceva-non-small cell lung cancer |
|
|
Term
| What is the mechanism of axn of antimetabolites? |
|
Definition
| Resemble substrates and enter into synthesis which leads to cell death. |
|
|
Term
| What is the mechanism of axn of alkylating agents? |
|
Definition
|
|
Term
| What is the mechanism of axn of aromatase inhibitors? |
|
Definition
| They act by ingibiting the conbersion of androgens to estrogens by aromatase enzyme in peripheral tissues (adrenal and adipose) |
|
|
Term
| Name 2 selective estrogen receptor modulators (SERM) |
|
Definition
|
|
Term
| What seratonin receptor inhibitor would you use as an antiemetic? |
|
Definition
|
|
Term
| What class of cancer tx drugs would you use for ALL (acute lymphocytic leukemia? |
|
Definition
|
|
Term
| What drug would you use to treat non-small cell lung cancer that is a plant alkaloid? |
|
Definition
|
|
Term
| What does L-asparaginase treat? |
|
Definition
| Acute lymphocytic leukemia |
|
|
