Term
| Hypersensitivity reactions can kill in what two ways |
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Definition
1. humoral via Ab
2. cell-mediated |
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Term
| normally IgE and Eosinophils are meant to battle what? In type I hypersensitivity reactions they beign to what which is not good. |
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Definition
| Normally IgE and Eosinophils are known for their parasite killing mechanisms which is good. But they are to blame in hypersensitivity reactions in which they are agressive to non parasites and to Ag otherwise normal. (food Ag, asthma ect..) |
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Term
| what is similar to histamine but slower, and 1000x more potent |
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Definition
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Term
| name four seconary mediators in type I hypersensitivity reactions that are similar to histamine |
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Definition
1. leukotrienes
2. prostaglandins
3. PAF
4. Bradykinin |
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Term
| which leukotriene is similar to histamine |
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Definition
| LTC4, LTD4, LTE4 are similar to histamine but 1000 more potent. Remember LTB4 is a chemotactic molecule that attracts eosinophils and neutrophils. Does not act like histamine |
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Term
| name five cytokines/chemokines that are active in type I hypersensitivity reactions |
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Definition
1. IL-4
2. IL-5
3. IL-8
4. IL-13
5. TNF alpha |
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Term
| what is the purpose of cytokines/chemotactic molecules in type I hypersensitivity reactions |
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Definition
| The whole point of type I hypersensitivity is to get the immune system involved. In particular to get IgE's and its primary hitmen mast cells. But they aren't the only ones to show up to the party. The cytokines and chemotactic molecules also get neutorphils, macrophages and TH2 involved since they are all one big Staten island family. The extra people to the party are known as secondary effector cells. |
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