Term
| Cell-mediated responses include which type of cells? 4x. Which are specific and which are non-specific |
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Definition
Specific: Tcytotoxic and lymphocytes
Nonspecific: Phagocytic and NK Cells |
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Term
| What kind of cells do cell mediate immune cells target 3x |
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Definition
1. cells with INTRACELLULAR pathogens
2. tumor cells
3. Graft rejections |
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Term
| The predominant response in delayed hyeprsensitivty reactions is cell mediated or humoral? |
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Definition
PRimary = cell mediated
Some Ab do respond but not much. |
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Term
| PRimary cytotoxic T cells are CD4 or CD8 |
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Definition
|
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Term
| do NK cells have CD8, CD4, CD3 or A TCR on their surface? |
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Definition
|
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Term
| do NK cells have antigen receptors |
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Definition
| NO. Therefore they are not MHC restricted. |
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Term
| MHCs class ___ are on every cell, while MHCs of Class ____ are only on APCs and lymphocytes |
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Definition
| MHCs of Class I are on every cell, while MHCs of Class II are only on APCs and lymphocytes |
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Term
| how does cell mediated immunity work in regards to MHC |
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Definition
| You see, if a T cell is running around and encounters MHC Class I on every cell it bumps into, it recognizes every cell as belonging in the body, and no immune response will occur. However, if a T cell runs into a cell that doesn't display an MHC, the T cell will immediately know that that cell doesn't belong in our bodies; the cell-mediated immune response will then begin, and the foreign cell will be destroyed. |
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Term
| four steps in cell-mediated immunity. They are: |
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Definition
four steps in cell-mediated immunity. They are:
antigen presentation
antigen binding (recognition)
co-stimulation
destruction of infector |
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Term
| what type of cells in the body are MHC I found on |
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Definition
| MHC I: MHC I molecules are found on all healthy nucleated cells in the body |
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Term
| whats the difference between cell mediated and humoral immunity |
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Definition
| Unlike humoral immunity, which is designed to react against extracellular antigens, cell-mediated immunity is much better at recognizing and eliminating microbes that are within cells. |
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Term
| Which type of T cells are involved in stimulating IgE production and Eosinophils |
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Definition
| Th-2 cells are involved in stimulating IgE production and eosinophils. |
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Term
| what causes apoptosis of Tc cells when their no longer really needed |
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Definition
| the decrease in IL-2 which is the main cytokine stimulator for cell mediated response. Less that then obviously decrease need for Tc cells. |
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Term
| how do the granzmes released by Tc cells not kill themselves? |
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Definition
| Tc cells have protective molecules ontheir surface that are called "protectins" |
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Term
| T/F APC secretions (cytokines) have a direct effect on Tc cells |
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Definition
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Term
| Tc Cells can be directly influenced by what other T cells |
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Definition
| TH1 cells and their secretion of cytokines. Don't forget APC can influence TH1 and therefore INDIRECTLY influence Tc cells. By way of TH1 cells more IL-2 is released and sitmulates more prolife and diff and insertion of more IL-2 receptors on cell surface. |
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Term
| Name 2x surface adhesion molecules found on mature Tc Cells |
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Definition
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Term
| NKT cells also referred to as __ cells |
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Definition
|
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Term
|
Definition
| glycolipids bound to CD1d rather than peptides bound to MHC I |
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Term
| What are similar between NKT and NK cells |
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Definition
| Both have innate responses but also possess adaptive responses |
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Term
| what is similar between NKT cells and Tc cells |
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Definition
| Both NKT and Tc cells have TCR on surface. NK cells do not |
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Term
| do NKT cells or NK cells act similar to helper cells in regards to cytokines and Tc cellsin regards to killing |
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Definition
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Term
| Do NKT and NK cells form memory cells. |
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Definition
| NO. ONLY NK cells can form memory cells. NKT CANNOT |
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Term
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Definition
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Term
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Definition
| Ab-dependent cel-mediated (cellular) cytotoxicity |
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Term
| what effector cells are categorized in the ADCC group |
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Definition
1. NK cells via FcR (CD16)
2. Macrophages
3. monocytes
4. neutrophils
5. Eosinophils |
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Term
| ADCC works via what strucutre |
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Definition
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Term
| the binding in ADCC results in what killing mechanism |
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Definition
1. digestive enzymes
2. perforins released by NK and eosinophils |
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Term
| what cytokines are released by ADCC cells |
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Definition
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