Term
| Which B cell subtype is found mostly in the pleural and peritoneal cavity |
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Definition
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Term
| Which B cell subtype has the most V region diversity |
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Definition
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Term
| Which B cell subtype has the highest level of surface IgD |
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Definition
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Term
| Which B cell subtype is known as conventional B cells |
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Definition
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Term
| Which B cell subtype found mostly in spleen or other marginal zones |
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Definition
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Term
| Whats so unique about B-1 Cells |
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Definition
| THey are the first B cells to develop during fetal life. They are most common in the periotneal and pelural cavities (lungs and GI). They can self renew and don't need bone marrow for replacement. This makes this versatile and indepedent. Unfortunately since they don't need other organs their diversity is limited. They have mostly surface IgM and CD5. They have low affinity. They don't need T cells for activiation. And have little to no memory. |
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Term
| which type of B cells are helped mostly by neutrophils and dendritic cells |
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Definition
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Term
| what class of B cells are self renewing |
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Definition
1. B-1 B cells
AND
2. Marginal B cells |
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Term
| what B cell class is predominant in the 2nd lymph tissues (lymph nodes and spleen) |
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Definition
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Term
| what is on neutrophils and dendritic cells that helps them activate Marginal zone B cells |
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Definition
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Term
| which Class of B cells have a tendancy to interact with complement factor |
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Definition
| MArginal B cells have CD21 which is a complement receptor (CR2) for C3d. C3d can bind to Ag and thus present the Ag-C3d complex to MArginal Zone B cells. |
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Term
| which class of antigens are more soluble in nature |
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Definition
| Thymus DEPENDENT Antigens are more soluble proteins. |
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Term
| antibody formation is what type of immune response |
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Definition
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Term
| Name the four phases of Ab primary response |
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Definition
| 1. lag phase 2. log phase 3. Plateau phase 4. Decline phase |
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Term
| Is the LAG phase longer in secondary or primary immune response? |
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Definition
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Term
| Is the LOG phase stronger in secondary or primary immune response? |
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Definition
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Term
| the lag phase for insoluble Ag in the primary response is? |
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Definition
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Term
| what happens to plasma cells after primary immune response |
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Definition
1. most die a couple weeks after
2. some plasma cells continue to secerete Ab to specific Ag for life of the host.
3. Memory B cells circulate. |
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Term
| vaccinations stimulate primary or secondary immune response |
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Definition
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Term
| somatic hyper-mutation of B cells primarily occurs in the primary or secondary response |
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Definition
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Term
| activation of B cells usually occurs where |
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Definition
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Term
| CD40L is expressed on TH cells or B cells? On activated or inactivated? |
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Definition
| TH Cells have to be activated first before they will express CD40L |
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Term
| B cells differentiate into what |
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Definition
| plasma cells or memory cells. |
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Term
| what Ig is expressed on naive B cells |
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Definition
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Term
| What Ab/Ig are expressed on memory B cells x3 |
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Definition
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Term
| signal transduction as a result of BCR binding to Ag involves what type of reaction in the intracellular regions |
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Definition
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Term
| how does CD22 cellulary act as a B cell inhibitory coreceptor? |
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Definition
| dephosphorylates Igalpha and Igbeta on BCR to decrease intraceullar signalling. |
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Term
| After successful T and B cell interaction the B cells will migrate and do one of two things |
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Definition
1. Migrate to T and B cell areas to form primary Foci and differentiate into plasma and memory cells
2. Migrate to follicles to proliferate, differentiate and form germinal centers where B cell will undergo somatic hypermutation and class switching. |
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Term
| Do plasma cells have lots of membrane bound Ig? |
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Definition
| NOOO. Very little because their primary job as effector B cells is to make and release soluble Ab. Therefore they are no longer able to be stimulated by Ag |
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Term
| How long do Plasma cells live for |
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Definition
| 5-10 days producing Ab then undergo apoptosis . |
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Term
| Plasma cells can do one of two things |
|
Definition
1. produce lots of Ab and then die in 5-10 days
2. become long lived producing Ab after traveling to bone marrow. |
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Term
| where do memory B cells circulate |
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Definition
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Term
| what is the difference in affinity and overall #s of CTLA-4 and CD28 |
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Definition
CD28: High #'s, low affinity
CTLA-4: Low #'s, High Affinity |
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Term
| Central memory T cells are found where? Effector memory T cells are found where |
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Definition
Central memory T cells: between secondary lymph tissues
Effector Memory T cells: in teritary tissues |
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Term
| extracellular Ag will activate CD4 T cells to differentiate into TH1 or TH2 cells? |
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Definition
| TH2 cells (b/c that favors Ab formation and Ab love attacking Ag directly in serum) |
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Term
| Intracellular virus or bacteria will activate CD4 T cells to differentiate preferentially to TH1 or TH2 cells? Why? |
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Definition
| TH1 cells because those will than activate the cell mediated immune system which will be better at pathogens who have entered cells. |
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Term
| which T cell type works mostly in the lymph nodes |
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Definition
| T follicular helper cells |
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Term
| cytokines from TH_ __ cells help to further enchance or activate macrophages |
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Definition
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Term
| macrophages can be activated to process and present Ag by what three things |
|
Definition
1. Engulfment on its own
2. Cytokine signals from TH1 cells
3. PRR on its surface recognizing specific pathogen associated molecular patterns |
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