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Histology
Professional
10/18/2011

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Term
N-acetyl cysteine
Definition
Mucolytic by breaking disulfide bonds. Used in Cystic Fibrosis
Term
Protamine sulfate
Definition
To treat excessive bleeding from heparin. Derived from fish sperm/testes
Term
Urokinase
Definition
Fibrinolytic. Activates FREE plasminogen so danger of Fibrinolytic state;From fetal renal cells;Expensive
Term
Aspirin
Definition
Inhibits platelet aggregation/vasoconstriction by blocking COX. Used in Polycythemia, PAD
Term
Timolol
Definition
Beta-Blocker -> First line treatment for tremor. Avoid in asthma.
Term
Almitrine
Definition
Respiratory Stimulant
Term
Pseudoephedrine
Definition
System Decongestant. Alpha Adrenergic Agonist
Term
Argatroban
Definition
Direct Thrombin Inhibitor (Parenteral Anticoagulant)
Term
Nedocromi
Definition
Used for asthma.
Term
Warfarin
Definition
Oral Anticoagulant. Antagonizes Vit K cofactor function of coagulation
Term
Anesthetic (local)
Definition
Act on stretch receptors to suppress cough. More effective than codeine.
Term
Sulfinpyrazone
Definition
Inhibits platelet aggregation. Is a uricosuric (Oral)
Term
Captopril (Angiotensin converting enzyme inhibitor)
Definition
Avoid in asthma. May cause dry cough as an ADR.
Term
Darbepoietin
Definition
Erythropoeitin-like. Can treat Anemia, Myelofibrosis(Fibrous tissue replaces RBC stem cells).
Term
Potassium channel openers
Definition
Suppress Bronchoconstriction, hypersecretion, cough, and airway hyperactivity.
Term
Deferasirox
Definition
Has longer t1/2, orally effective, and low affinity for other metals Vs. Deferoxamine.
Term
Heparin
Definition
Parenteral Anticoagulant. Binds/induces anti-thrombin III. Inhibits Factors X, II. Releases Tissue Factor
pathway inhibitor of Xa.
Term
Furosemide (diuretics)
Definition
Treats Thrombocytopenia (SC) by activating the thrombopoietin receptor to increase platelet count
Term
Drotrecogin
Definition
Parenteral anticoagulant. Recombinant Protein C (parenteral). A glycoprotein serine protease.
Term
Hydroxyurea
Definition
Decreases Neutrophils/Monocytes -> treat Polycythemia. Stimulate Hgb production -> treat
Myelofibrosis/Sickle Cell. Increases NO. Increases uric acid in blood.
Term
Oprelvekin
Definition
Treats Thrombocytopenipratroia (SC). Is IL-11 that stimulates stem cells to become megakaryocytes.
Term
Phenindione
Definition
Oral anticoagulant. Indandione derivative similar to warfarin. Severe hypersensitivity risk.
Term
Zileuton
Definition
Treats asthma by blocking 5-LPO therefore blocking leukotrine synthesis. CYP metabolized
Term
Tioptropium
Definition
Treats asthma as Muscarinic Antagonist. Longer duration than Ipratropium.
Term
Eptifibatide
Definition
Inhibits platelets aggregation. Binds Glycoprotein receptors. Peptide(IV).
Term
Ximelagatran
Definition
Direct Thrombin Inhibitor (Oral anticoagulant Prodrug). Hepatotoxicity.
Term
Deferoxamine
Definition
Has shorter t1/2, only parenterallly effective, and higher affinity for other metals Vs. Defasirox.
Term
Fondaparinux
Definition
Parenteral Anti-coagulant. Very specific for blocking Xa via binding reversibly to anti-thrombin III.
Term
Sildenafil
Definition
PDE5 inhibitor. 20mg treats Pulmonary Hypertention. 50 mg treats Erectile Dysfunction.
Term
Ephedrine
Definition
Adrenergic Agonist for decongestion and bronchodilation
Term
Omalizumab
Definition
Monoclonal antibody to decrease Mast Cell release of Leukotrines.
Term
Vasopressin
Definition
ADH). Will vasoconstrict and increase BP for Cardiopulmonary Arrest..
Term
Clopidogrel
Definition
Inhibits Platelet Aggregation by binding Purinergic receptors. Less ADRs/Faster Onset than Ticlopidine
Term
Enoxaparin
Definition
Parenteral anticoagulant. Low MW heparin. Induces anti-thrombin III. Affects Xa more than II.
Term
Anistreplase
Definition
Fibrinolytic. Activates FREE plasminogen so danger of Fibrinolytic state. Synthesized. Longer t1/2.
Term
Ticlopidine
Definition
Inhibits Platelet Aggregation by binding Purinergic receptors. More ADRs. 8-11 days Onset
Term
Prostacyclin
Definition
Inhibits Platelet Aggregation and treats Pulmonary HTN via vasodilation. For Eisenmenger syndrome.
Term
Tirofiban
Definition
Inhibits Platelet Aggregation. Binds Glycoprotein receptors. Non-peptide(IV).
Term
Benzonatate
Definition
Local anesthetic that blocks stretch receptors at alveoli/bronchi to inhibit cough
Term
Streptokinase
Definition
Fibrinolytic. Activates FREE plasminogen so danger of Fibrinolytic state. From bacteria.
Term
Danaparoid
Definition
Parenteral anticoagulant. Used during heparin induced Thrombocytopenia and Hip Surgery prophylaxis.
Term
Ranitidine
Definition
H2 Receptor block for treatment of Mild GERD. Less potent than a PPI.
Term
Abciximab
Definition
Inhibits platelets aggregation. Binds Glycoprotein receptors. Monoclonal Antibody(IV).
Term
Dornase
Definition
Breaks down the DNA present in the thick fluid of mucous as seen in Cystic Fibrosis.
Term
Saline
Definition
Irrigates and smooths the irritated tissue in congestion
Term
Phenylpropanolamine
Definition
Systemic Decongestant with low Therapeutic index
Term
Codeine
Definition
Cough Suppressant. Morphine derivative with decreased analgesic activity.
Term
Tranexamic acid
Definition
Treats bleeding by inhibiting plasminogen activation. (Opposite of fibrinolytics like streptokinase)
Term
Dextromethorphan
Definition
Cough Suppressant. Morphine derivative with decreased analgesic activity. (Preferred to codeine)
Term
Dapsone
Definition
Inhibits synthesis of dihydrofolic acid. May lead to hemolytic anemia
Term
Potassium iodide
Definition
Oral expectorant. Induces excretion of fluid which lowers the mucuos viscosity.
Term
Treprostinil
Definition
Prostacyclin(parenteral) for Pulmonary HTN. Longer t1/2
Term
Epoprostenol
Definition
Prostacyclin(parenteral) for Pulmonary HTN. Shorter t1/2
Term
t-plasminogen activator
Definition
Fibrinolytic(Alteplase). Activates plasminogen BOUND TO FIBRIN, so less danger of fibrinolytic state.
Term
Terbutaline
Definition
Beta Agonist for COPD
Term
Pentoxyfylline
Definition
PDE4 inhibitor, TNF blocker. Alters viscosity and increases blood flow in Sickle cell and PAD.
Term
Zafirlukast
Definition
Leukotrine Receptor blocker. For children >5. Shorter t1/2. For asthma. CYP metabolized
Term
Omeprazole
Definition
Proton Pump Inhibitor. Used in treatment of GERD.
Term
Prostaglandin
Definition
Causes inflammation/bronchoconstriction/platelet aggregation/uterine contractions. Decreases IOP.
Term
Cromolyn
Definition
Mast cell membrane stabilizer. Inhibits degranulation.
Term
Corticosteroids
Definition
Inhibits lipocortin to decrease Prostaglandins. Treats Pulmonary HTN, Congestion(2-3days), Asthma.
Term
Oxymetazoline
Definition
Nasal Decongestant. Alpha adrenergic. Longest duration.
Term
Decitabine
Definition
Increases fetal Hgb production by inhibiting methylation of DNA and thus stops gamma -> beta globulin
Term
Riboflavin
Definition
Deficiency -> Aplasia, Anemia, Angular Stomatitis/Cheilosis
Term
Aminocaproic acid
Definition
Treats bleeding by inhibiting plasminogen activation. (Opposite of fibrinolytics like streptokinase)
Term
Eltrombopag
Definition
Treats Thrombocytopenia (oral) Activates thrombopoietin receptor to increase platelets. Hepatotoxic
Term
Montelukast
Definition
Leukotrine Receptor blocker. For children >2. Longer t1/2. For asthma. CYP metabolized.
Term
Theophylline
Definition
PDE inhibitor(increases cAMP), Adenosine receptor block. For asthma. A Methylxanthine.
Term
Bosentan
Definition
Endothin-A(ET-A) receptor antagonist. For Pulmonary HTN and Eisenmenger syndrome.
Term
Diphenhydramine
Definition
Antihistamine(Inverse agonist) and local anasthetic. For allergy. Sedative.
Term
Immunotherapy
Definition
Administering of gradually increasing allergen to build tolerance. Expensive and requires compliance.
Term
Vitamin A
Definition
Carotene. Dietary supplement that can be used during COPD.
Term
Vitamin D
Definition
Precursor from skin at sun exposure. Processed in liver/kidney. Used to help absorption of Calcium.
Term
Vitamin E
Definition
Tocopherol/Ergocalciferol. A powerful antioxidant.
Term
Vitamin K
Definition
A cofactor for Coagulation. Competes against warfarin.
Term
Vitamin B1
Definition
Thiamine. Decreased due to alcohol consumption. Deficiency => Wernicke-korsakoff dementia
Term
Vitamin B2
Definition
Riboflavin. Deficiency -> Aplasia, Anemia, Angular Stomatitis/Cheilosis
Term
Vitamin B6
Definition
Pyridoxine(PLP). Deficiency leads to anemia, and neurological symptoms. ADRs: Decreased Sensation
Term
Vitamin B12
Definition
Associated with B12 deficiency anemia.
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