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Test 2 - Pharm Opiates
Opiates
54
Nursing
Graduate
10/13/2013
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Term
Fenatnyl Concentration
 Definition
50mcg/ml. (epidural 5mcg/ml.
Term
Fenatnyl Dose (Induction)
 Definition
5 to 40mcg/kg.
Term
Fenatnyl Dose Analgesia
 Definition
0.7 to 2mcg/kg.
Term
Fenatnyl Sole Anesthetic TIVA
 Definition
50 to 150mcg/kg.
Term
Fenatnyl PCA.
 Definition
15 to 100mcg/hr.
Term
Fenatnyl Epidural.
 Definition
25 to 60mcg/hr.
Term
Fenatnyl Onset.
 Definition
30 seconds.
Term
Fenatnyl Peak.
 Definition
5 to 15 minutes.
Term
Fenatnyl Duration.
 Definition
30 to 60 minutes.
Term
Fenatnyl Volume of Dist.
 Definition
4L/kg.
Term
Fenatnyl Protein Bound
 Definition
84%
Term
Fenatnyl Elemination 1/2 Time.
 Definition
3 hours.
Term
Fenatnyl Metabolized via.
 Definition
Liver: N-demethylation to norfentanyl.
Term
Fenatnyl Excreted.
 Definition
Kidney. Present in urine for 72 hours.
Term
Sufantanil Dose (Induction).
 Definition
2 to 10mcg/kg.
Term
Sufantanil Dose Analgesia.
 Definition
0.2 to 0.6 mcg/kg.
Term
Sufantanil Sole Anesthetic TIVA.
 Definition
10 to 30mcg/kg.
Term
Sufantanil Onset.
 Definition
1 to 3 min.
Term
Sufantanil Peak.
 Definition
3 to 5 min.
Term
Sufantanil Duration.
 Definition
20 to 45 min.
Term
Sufentanil Volume of Dist.
 Definition
2.48 (smaller than fent).
Term
Sufantanil Protein Bound
 Definition
92% (larger than fent).
Term
Sufantanil Elemination 1/2 Time.
 Definition
2 Hours.
Term
Sufantanil Metabolized via.
 Definition
Liver CP450.
Term
Sufantanil Excreted.
 Definition
Urine and feces.
Term
Sufantanil Strength.
 Definition
10x Stronger than Fentanyl.
Term
Sufantanil Lipid solubility?
 Definition
High.
Term
Remifantanil Loading Dose Analgesia.
 Definition
0.5 to 1mcg/kg. over 30 seconds.
Term
Remifantanil Dose Infusion.
 Definition
.05 to 2mcg/kg.
Term
Remifantanil Onset.
 Definition
Less than 1 min. (ultra short acting).
Term
Remifantanil Peak.
 Definition
1 min.
Term
Remifantanil Duration.
 Definition
5 to 10 min.
Term
Remifantanil Context sensitive half time.
 Definition
5 min.
Term
Remifantanil Volume of Dist.
 Definition
small.   Ester hydrolysis accounts for short duration.
Term
Remifantanil Protein Bound
 Definition
70% protein bound.
Term
Remifantanil Metabolized via.
 Definition
Ester hydrolysis to inactive metabolite.
Term
Remifantanil Excreted.
 Definition
Kidney.
Term
Remifantanil Strength.
 Definition
15-20x stronger than alfentanyl or 2x as potent as fentanyl.
Term
Morphine Dose (Induction)
 Definition
1 milligrams/kg (said to induce surgical anesthesia).
Term
Morphine Dose Analgesia
 Definition
2 to 15 milligrams titratd to effect 1-2 milligrams doses.
Term
Morphine Onset.
 Definition
1 to 5 minutes. IM More towards 5min.
Term
Morphine Peak.
 Definition
5 to 20 minutes IV 30-60min IM.
Term
Morphine Duration.
 Definition
2 to 7 hours.
Term
Morphine Elemination 1/2 Time.
 Definition

1.7 to 3.3 hours.

2.5 Hours Mean.
Term
Morphine Metabolized via.
 Definition

Conjungation in liver via phase II

MAO inhibitor may disrupt metabolism.
Term
Morphine Excreted.
 Definition
Mainly kidney. 7 to 10% billiary.
Term
Hydromorphone Dose.
 Definition
0.2 to 0.6mg q2-q3 hours.
Term
Hydromorphone Protein Binding.
 Definition
Low.
Term
Hydromorphone Metabolism.
 Definition
Liver via Phase II gluconuric conjugation.
Term
Hydromorphone Excretion.
 Definition
Kidney.
Term
Hydromorphone Onset
 Definition
3-5 minutes
Term
Hydromorphone Duration.
 Definition
4-5 hours
Term
Sufentanyl Dose Anesthesia Infusion.
 Definition
0.1 to 0.5 mcg/kg/min.
Term
Sufentanil Analgesia Bolus
 Definition

0.6 to 4mcg/kg.

 
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