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Test 2 - Pharm Induction
Induction agents
60
Nursing
Graduate
10/13/2013
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Term
Naloxone Concentration. What should concentration be?
 Definition
0.4mg/ml amp. Draw up with 3cc NS for a .1mg per ml concentration
Term
Naloxone Dose.
 Definition
0.05 to .1 mg increments to effect.
Term
Naloxone Onset.
 Definition
1 to 2 min.
Term
Naloxone Duration.
 Definition
30 to 45 min.
Term
Naloxone Elemination 1/2 Time.
 Definition
60 to 90 min.
Term
Naloxone Metabolism.
 Definition
Liver, undergoes first pass effect 1/5 oral potency.
Term
Nalmefene Dose
 Definition
0.5 to .1mg IV
Term
Nalmefene Half Time.
 Definition
10 hours.
Term
Propofol Concentration.
 Definition
10mg/ml in 1% solution.
Term
Propofol Dose (Induction).
 Definition
2.0 to 2.5mg/kg
Term
Propofol Dose Anesthesia Maintenance.
 Definition
100 to 200mcg/kg/min infusion or 25 to 50mg boluses. Decrease doses in geratric and debilitated.
Term
Propofol Dose Sedation bolus.
 Definition
25 to 50mg (0.5 to 1.0mg/kg).
Term
Propofol Dose Sedation Infusion.
 Definition
20 to 75mcg/kg/minute.
Term
Propofol Dose Antemetic.
 Definition
10mg.
Term
Propofol Dose Piuretic.
 Definition
10mg.
Term
Propofol Onset.
 Definition
Less than 40 seconds.
Term
Propofol Duration.
 Definition
5 to 10 minutes.
Term
Propofol Volume of Dist.
 Definition
60L/kg.
Term
Propofol Elimination 1/2 Time.
 Definition
30 to 90 minutes. Clearance slowed in geriatric population.
Term
Propofol Context Sensative 1/2 Time.
 Definition
Less than 40 minutes > for obese patients due to fat stores.
Term
Propofol Metabolized via.
 Definition
Liver via conjugation to glucuronide phase II. Clearance > than liver metabolism.
Term
Propofol Protein Binding.
 Definition
95 to 99%.
Term
Ketamine Concentration.
 Definition
10, 50, 100mg / ml vials.
Term
Ketamine Dose (Induction)
 Definition
1.0 to 2.5 mg/kg IV 5 to 10mg/kg IM.
Term
Ketamine Dose Analgesia
 Definition
0.5 to 1.0 mg/kg/ IV. 2.5 to 5 mg/kg IM.
Term
Ketamine Onset.
 Definition
30 to 60 seconds IV. 3 to 4 minutes IM.
Term
Ketamine Duration.
 Definition
10 to 20 minutes awake. Fully recovered in 60 to 90 minutes.
Term
Ketamine Elemination 1/2 Time.
 Definition
2.5 to 3 hours.
Term
Ketamine Metabolized via.
 Definition
Hepatic N-demethylation via P450.
Term
Ketamine Excreted.
 Definition
90% Renal.
Term
Thiopental Dose Induction.
 Definition
3 to 5mg/kg.
Term
Thiopental Dose Sedation.
 Definition
20 to 50mg IV.
Term
Thiopental Dose Anticonvulsant.
 Definition
0.5 to 2mg/kg.
Term
Thiopental Dose to treat increased ICP.
 Definition
1.2 to 2.5mg/kg.
Term
Thiopental Onset.
 Definition
10 to 20 seconds.
Term
Thiopental Peak.
 Definition
30 seconds.
Term
Thiopental Duration.
 Definition
5 to 15 minutes.
Term
Thiopental Elimination half-time
 Definition
11 hours.
Term
Thiopental Volume of Distribution
 Definition
2.5L/Kg. Much lower than prop.
Term
Methohexital Dose Induction.
 Definition
1.5 to 2.5mg/kg.
Term
Methohexital Dose Sedation.
 Definition
10 to 20mg.
Term
Methohexital Dose infusion.
 Definition
50 to 150 mcg/kg/min.
Term
Methohexital Onset.
 Definition
20 to 40 seconds.
Term
Methohexital Peak.
 Definition
30 seconds.
Term
Methohexital Duration.
 Definition
5 to 10 minutes I.V. and 60 min rectal.
Term
Methohexital Strength.
 Definition
2x greater than Thiopental.
Term
Methohexital Elimination half-time.
 Definition
4 hours.
Term
Methohexital Volume of Distribution
 Definition
2.2L/Kg. Slightly lower than thiopental.
Term
Etomidate Concentration.
 Definition
2mg/ml
Term
Etomidate Dose (Induction).
 Definition
0.1 to 0.4 mg/kg (rarely used as infusion).
Term
Etomidate Onset.
 Definition
Less than 60 seconds.
Term
Etomidate Duration.
 Definition
3 to 10 minutes.
Term
Etomidate Peak.
 Definition
1 minute.
Term
Etomidate Volume of Distribution
 Definition
Large. Suggesting large tissue uptake.
Term
Etomidate Elimination 1/2 Time.
 Definition
2 to 5 hours.
Term
Metabolized via.
 Definition
Rapidly by liver and plasma by ester hydrolysis.
Term
Etomidate Protein Binding.
 Definition
76%
Term
Precedex Dose Loading:
 Definition
1mcg/kg over 10 minutes.
Term
Precedex Dose Maintenance:
 Definition
0.2 to 0.7 mcg/kg/hr titrated.
Term
Precedex Onset.
 Definition
5 to 10 minutes.
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