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Test 2 Immunology Blood Antigens and Blood Typing
Test 2 Immunology Blood Antigens and Blood Typing
23
Immunology
Graduate
03/05/2015

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Cards

Term
how many different types of antigens are on the surface of a RBC
Definition
50
Term
bombay type refering to ABO Blood typing is?
Definition
No H Substance
Term
the antibody in the plasma related to ABO Blood typing is
Definition
IgM
Term
codominant blood refers to what blood type
Definition
AB blood. No antibodies to either A or B.
Term
homozygous recessive blood type is
Definition
O
Term
under certain situations other than IgM this antibody may also be made when considerable transfusions and exposures have occurred
Definition
IgG
Term
Which kind of antibody can cross the placenta
Definition
IgG
Term
What type of reaction occurs with incorrect matching of blood and a blood transfusion
Definition
Antibody-mediated cytotoxic (Type II) Hypersensitivity reaction
Term
The antibodies of the patient may attack the blood being donated. what happens
Definition
1. agglutination
2. hemolysis (from complement-mediated, opsonization)
3. clumped cells clog vessels of organs
Term
whats the difference between PRBCS and whole blood
Definition
PRBCs lacks the large amount of plasma in whole blood. Remember that anitbodies are in Plasma.
Term
AB Antigens are only found on blood T/F
Definition
False. They are found almost everywhere in the body
Term
The most potent of the Rh Ag is
Definition
RhD Ag
Term
Are more people Rh positive or negative
Definition
85% of people in US are Rh positive
Term
Rh positive means you have what present
Definition
RhD Ag
Term
are there more Rh antigenic sites or more A1 antigenic sites
Definition
More A1 antigenic sites (1mil : 20,000)
Term
If a person has Rh negative blood then they will not have a RhD on their RBC, but will they have Ab in the plasma?
Definition
NO. Not unless they have been exposed to someone elses RhD. (transfusion, or pregnancy)
Term
the most common and strongest of Rh antibodies is
Definition
Anti-RhD
Term
This antibody is present with much higher levels after 2nd exposure to Ag
Definition
IgG is present in MUCH higher levels than IgM in second exposure reactions. IgG  can cross placenta and kill baby.
Term
What does RhoGam do
Definition
Is contains anti-RhD Ab that will give active immunity to mom who is Rh Negative to address the contamination of her blood during pregnancy by Rh positive child.
Term
what is hemolytic disease of newborns
Definition
Mom has anti-RhD antibodies and those cross placenta and destroys the RBCs of the fetus.
Term
Sx of hemolytic disesase of a newborn
Definition
more blue from destroyed RBCS from mom, IF severe baby is jaundiced becausre their immature livers can't keep up with byproducts of RBC lysis which is bilirubin. It becomes too much and toxic.
Term
Maternal Anti-RhD Antibodies that enter the fetus can linger for how long
Definition
1-2 months; therefore causing prolonged hemolysis and disease to the feta RBC system
Term
Most common to see ABO incompatibliity hemolyti disease in mothers who have Type _____ and babies who have ___ or ___
Definition
Moms with type O and babies with A or B
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