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TEST 2
renal, autocoids, endocrine, respiratory, GI
153
Pharmacology
Graduate
02/05/2012
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Term
Cromolyn Sodium
 Definition
Mast Cell Stabilizer
Term
Nedocromil
 Definition
Mast Cell Stabilizer
Term
Diphenhydramine
 Definition
H1R antagonist
Term
fexofenadine
 Definition
H1R antagonist
Term
Loratidine
 Definition
H1R antagonist
Term
Cimetidine
 Definition
H2R antagonist
Term
Rantidine
 Definition
H2R antagonist
Term
Famotidine
 Definition
H2R antagonist
Term
Nizatidine
 Definition
H2R antagonist
Term
Ergotomine
 Definition
Partial agonist at 5HTR
Term
ergonovine
methylergonovine
 Definition
Partial agonist at 5HTR
Term
Sumatriptan
 Definition
5HT1R agonist
Term
zolmitriptan
 Definition
5HT1R agonist
Term
Naratriptan
 Definition
5HT1R agonist
Term
rizatriptan
 Definition
5HT1R agonist
Term
odansetron
 Definition
5HT3R antagonist
Term
alosetron
 Definition
5HT3R antagonist
Term
Carboprost
 Definition
Prostaglandin-PGF2alpha
Term
dinoprostone
 Definition
prostaglandin-PGE2
Term
alprostadil
 Definition
prostaglandin-PGE1
Term
misoprostol
 Definition
prostaglandin-PGE1
Term
epoprostenol
 Definition
prostaglandin-PGI2
Term
Zafirlukast
 Definition
leukotriene antagonist
Term
montelukast
 Definition
leukotriene antagonist
Term
zileuton
 Definition
5 lipoxygenase inhibitor
Term
mannitol
 Definition
osmotic diuretic
Term
acetazolamide
 Definition
PT diuretic
Term
furosemide
 Definition
LOH diuretic
Term
ethacrynic acid
 Definition
LOH diuretic
Term
thiazide
 Definition
distal convoluted tubule diuretic
Term
indapamide
 Definition
distal convoluted tubule diuretic
Term
spironolactone
 Definition
CT diuretic
Term
triameterene
 Definition
CT diuretic
Term
amiloride
 Definition
CT diuretic
Term
Nesirtide
 Definition
BNP
Term
desmopressin
 Definition
vasopressin 2 agonist
Term
indomethacin
 Definition
acute gouty arthritis
Term
sulindac
 Definition
acute gouty arthritis
Term
naproxen
 Definition
acute gouty arthritis-proprionic acid deriv
Term
cochicine
 Definition
acute gouty arthritis/prophylaxis in recurrent gouty arthritis
Term
probenecid
 Definition
recurrent chronic gouty arthritis- uricosuric agent
Term
sulfinpyrazone
 Definition
recurrent chronic gouty arthritis- uricosuric agent
Term
allopurinol
 Definition
recurrent chronic gouty arthritis-XO inhibitor
Term
febuxostat
 Definition
recurrent chronic gouty arthritis-XO inhibitor
Term
salicylate
 Definition
NSAID- cov modifies cox1/cox2
Term
Ibuprofen
 Definition
NSAID- non selective inhib cox1/cox2
Term
naproxen
naproxen/esomeprazole
 Definition
NSAID- non selective inhib cox1/cox2
Term
Ketorolac
 Definition
NSAID
Term
sulindac
 Definition
NSAID
Term
indomethacin
 Definition
NSAID
Term
non-acetylated salicylates
 Definition
NSAID
Term
celecoxib
 Definition
cox2 selective inhibitor
Term
acetominophen
 Definition
paramphenicol derivative
Term
Growth Hormone
 Definition
somatotropin recombinant dna derived gh
Term
octreotide acetate
 Definition
synthetic somatostatin (inhibits GH and 5-HT)
Term
Prolactin
 Definition
inhibits LH surge
Term
bromocriptine
 Definition
dopa agonist
Term
menotropins
 Definition
menopausal gonadotropins (FST+LH or just FSH)
Term
Leuprolide
 Definition
GnRH agonist (inhibits LH and FSH rel)
Term
Ganirelix acetate
 Definition
GnRH antagonist (inhibits LH rel)
Term
Oxytocin
 Definition
PP hormone
Term
vasopressin
 Definition
antidiuretic - V2R, vasopressor - V1R
Term
desmopressin
 Definition
(mainly) V2R agonist
Term
Levothyroxine
 Definition
synthetic T4
Term
liothyronine
 Definition
synthetic T3
Term
PTU
 Definition
inhibits peroxidase and deiodonase
Term
methimazole
 Definition
inhibits peroxidase
Term
propanolol
 Definition
inhibits deiodonase
Term
iodide
 Definition
inhibits thyroglobulin proteolysis
Term
131 iodide
 Definition
radioactive destruction of thyroid
Term
hydrocortisone
 Definition
mineralocorticoid and glucocorticoid
Term
prednisone
 Definition
high glucocorticoid and some mineralocorticoid
Term
dexamethasone
 Definition
very high glucocorticoid, no mineralocorticoid
Term
fludrocortisone
 Definition
high mineralocorticoid
Term
cosyntropin
 Definition
synthetic ACTH
Term
fluticasone proprionate
 Definition
nasal cortisone spray
Term
beclomethasone
 Definition
nasal cortisone spray
Term
metyrapone
 Definition
inhibits 11-deoxycortisol--> cortisol, inc mineralocorticoids
Term
spironolactone
 Definition
aldosterone competitive antagonist
Term
diethylstilbestrol
 Definition
synthetic estrogen
Term
ethinyl estradiol
 Definition
synthetic estrogen
Term
medroxyprogesterone
 Definition
synthetic progestin- intramuscular
Term
norethindrone
 Definition
synthetic progestin
Term
levonorgestrel
 Definition
synthetic progestin
Term
desogestrel
 Definition
synthetic progestin
Term
conjugated estrogens (premarin)
 Definition
post menopause tx
Term
clomiphene
 Definition
estrogen agonist and antagonist (mostly)
Term
tamoxifen
 Definition
SERM- antagonist at breast, agonist at bone
Term
raloxifene
 Definition
SERM- antagonist at breast, agonist at bone
Term
mifepristone
 Definition
progestin antagonist, glucocorticoid antagonist
Term
testosterone enanthate
 Definition
testosterone analogue
Term
oxandrolone
 Definition
testosterone analogue (more anabolic)
Term
finasteride
 Definition
inhibits conv of testosterone--> DHT
Term
anastrozole
 Definition
inhibits aromatase
Term
regular
 Definition
rapid insulin
Term
lispro
 Definition
rapid insulin
Term
aspart
 Definition
rapid insulin
Term
NPH
 Definition
intermediate insulin
Term
lente
 Definition
intermediate insulin
Term
ultralente
 Definition
slow
Term
glargine
 Definition
slow
Term
regular/nph
 Definition
mixture
Term
lispro protamine/lispro
 Definition
mixture
Term
chlorpropamide
 Definition
sulfonylurea-inc insulin release from beta cells
Term
glyburide
 Definition
sulfonylurea- inc insulin release from beta cells
Term
repaglinide
 Definition
stimulate insulin release
Term
metformin
 Definition
decrease hepatic glucose production
Term
acarbose
 Definition
decreases glucose absorption from GI tract- inhibits glucosidase enzyme
Term
rosiglitazone
 Definition
decreases insulin resistance (enhances cellular effects of insulin)
Term
exenatide
 Definition
enhances glucose dependant insulin release (like GLP-1)
Term
albuterol
 Definition
beta 2 agonist
Term
salmeterol
 Definition
beta 2 agonist
Term
terbutaline
 Definition
beta 2 agonist
Term
triotropium
 Definition
muscarinic R antagonist
Term
ipratropium
 Definition
muscarinic R antagonist
Term
theophylline
 Definition
methylxanthine- inhibit phosphodiesterase and stabilize mast cell
Term
omalimuzab
 Definition
monoclonal ab blocks ige binding to mast cells
Term
ondansetron
 Definition
setron- 5HT3 receptor antagonist
Term
granisetron
 Definition
setron- 5HT3 receptor antagonist
Term
dolasetron
 Definition
setron- 5HT3 Receptor antagonist
Term
aprepitant
 Definition
neurokinin R (NK1) antagonist
Term
prochloroperazine
 Definition
phenothiazine- dopa R antag and muscarinic R antag
Term
promethazine
 Definition
phenothiazine- dopa R antag and muscarinic R antag
Term
thiethylperazine
 Definition
phenothiazine- dopa R antag and muscarinic R antag
Term
lorazepam
 Definition
benzodiazepine- positive allosteric modulators of GABAa R
Term
alprazolam
 Definition
benzodiazepine- positive allosteric modulators of GABAa R
Term
metoclopramide
 Definition
D2 R antag in CTZ and NTS
Term
droperidol
 Definition
D2 R antag in CTZ and NTS
Term
trimethobenzamide
 Definition
D2 R antag in CTZ and NTS
Term
haloperidol
 Definition
D2 R antag in CTZ and NTS
Term
dexamethasone
 Definition
glucocorticoid
Term
methylprednisolone
 Definition
glucocorticoid
Term
scopolamine
 Definition
muscarinic antagonist
Term
promethazine
 Definition
H1R antag and M1R antag
Term
dronabinol
 Definition
cannabinoids
Term
hydroxycholorquine/chloroquine
 Definition
suppresses T cell responsiveness etc
Term
sulfasalazine
 Definition
anti-inflammatory and immunosuppressive
Term
methotrexate
 Definition
inhibits dihydrofolate reductase
Term
azathioprine
 Definition
inhibits B and T cell function
Term
pencillamine
 Definition
metabolite of PCN
immnunosuppressive
chelation therapy
Term
gold
 Definition
morph and fxn alterations in macrophages
Term
infliximab
 Definition
chimeric monoclonal Ab raised against TNFalpha
Term
etanercept
 Definition
recombinant fusion protein of TNF p75 receptor and Fc portion of IgG1
binds TNFalpha
Term
anakinra
 Definition
recombinant IL-R antagonist
Term
omeprazole
 Definition
irrev inhibits H/K ATPase
Term
sucralfate
 Definition
mucosal protective agent
Term
colloidal bismuth
 Definition
mucosal protective agent
Term
metoclopramide
 Definition
prokinetic agent- D2 R antag, 5HT4R agonist
Term
sulfasalazine
 Definition
dimer of mesalamine (5ASA) and sulfapyridine- diazo bond- 5 ASA inhibits cox etc
Term
osalazine
 Definition
dimer of 5ASA coupled via diazo bond- NO sulfapyridine
Term
mesalamine
 Definition
5ASA inhibits cox
Term
azathioprine/6-mercaptopurine
 Definition
suprress lymphocyte proliferation
Term
infliximab
 Definition
chimeric monoclonal antibody against TNFalpha
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