Term
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Definition
Direct acting anti-coagulant
-Increases aPTT
Works by accelerating AntithrombinIII
*Causes Hepar-induced thrombocytopenia (IgG against hep/platelet factor IV) |
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Term
| Low Molecular Weight Heparins (LMWH) |
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Definition
Direct acting anti-coag
-More predictable pharmacokinetics, greater bioavailability, greater therapeutic index |
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Term
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Definition
| Heparin antagonist (for overdose) |
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Term
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Definition
Indirect-acting Anticoag
Keeps Vit K from being reduced to active form
-Orally effective
*dont use in pregnancy |
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Term
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Definition
Anti-platelet
Irreversibly inhibits COX, prevent TXA2-mediated activation and adhesion
*can get induced airway hyperreactivity |
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Term
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Definition
Anti-platelet (phosphodiesterase inhibitor)
Increases intracellular cAMP |
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Term
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Definition
Anti-platelet
Blocks ADP receptors, which eliminates inhibtion of adenylyl cyclase (^cAMP) |
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Term
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Definition
Anti-platelet (synthetic peptide)
blocks GPIIb-IIIa |
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Term
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Definition
| Antiplatelet (non-peptide tyrosine analog)- binds GPIIb/IIIa, inhibits fibrin binding |
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Term
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Definition
Anti-platelet- syntetic (PGI2) analog
Increases action of adenyl cyclase (^cAMP) |
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Term
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Definition
Anti-platelet (hirudin analog)
-direct thrombin inhibitor |
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Term
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Definition
Thrombolytic
-Binds plasminogen and cleaves it (large loading does needed) |
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Term
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Definition
Thrombolytic (from fetal kidney cells)
-Directly cleaves plasminogen to plasmin |
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Term
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Definition
Thrombolytic (rt-PA
-Binds thrombus, undergoes conformational change, activates plasminogen (needs fibrin binding) |
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