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Physiology
Undergraduate 4
02/09/2012

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Term
Receptor Protein
Definition
Built into the plasma membrane of postsynaptic cell-accepts neurotransmitters
Term
Excitatory postsynaptic potential
Definition
Serves as the depolarization stimulus for the production of action potentials-conducted by cable properties from dendrite to axon hillock
Term
Inhibitory postsynaptic potential
Definition
Hyperpolarization of postsynaptic cell-decrease in amplitude when traveling towards axon hillock
Term
Ca in
Definition
Neurotransmitter is released when this element enters the axon.
Term
Cl-
Definition
This element has an inhibitory effect when it enters the cell
Term
Summation
Definition
Term used to describe when synaptic potentials ride piggyback on each other and produce a larger depolarization
Term
Nicotinic ACh receptors
Definition
Excitatory receptors, produce EPSPs, found in particular brain regions and skeletal muscle fiber, found in autonomic ganglia stimulating sympathetic and parasympathetic neurons
Term
Acetylcholinesterase
Definition
Breaks down ACh, stops stimulation
Term
Curare
Definition
Drug from south american trees that causes flaccid paralysis by blocking binding of ACh to nicotinic receptors
Term
Myasthenias gravis
Definition
Disease that causes flaccid paralysis due to autoantibodies that block muscle nicotinic ACh receptors
Term
Nerve gas
Definition
Causes spastic paralysis by inhibiting AChE
Term
Neostigmine
Definition
Clinical inhibitor of AChE to stimulate muscle contraction in diseases like myasthenia gravis
Term
GABA-gamma-aminobutyric acid
Definition
Inhibitory neurotransmitter that lets Cl- into the postsynaptic cell causing hyperpolarization
Term
Chorea
Definition
Uncontrolled movements in certain diseases
Term
Huntington's Disease
Definition
Neurodegenerative disorder caused by a deficiency of GABA releasing neurons
Term
Propofol
Definition
Drug that killed MJ that potentiates GABA receptor activity, lead to cardiac arrthymia, hypotension, and suppresion of respiratory activity
Term
G-protein coupled receptors
Definition
Receptors that use second messengers alpha beta and gamma
Term
Benzodiazepines
Definition
Drugs that increase the ability of GABA to activate its receptors in the brain and spinal cord. Example is Valium
Term
Muscarinic ACh receptors
Definition
Receptors that can be excitatory or inhibitory. G protein coupled receptor
Term
Examples of monoamines
Definition
Dopamine, norepinephrine, epinephrine, adrenaline, serotonin, catecholamines (derived from tyrosine)
Term
cyclic AMP
Definition
Second messenger for monoamine neurotransmitters, activates protein kinase
Term
Adenylate Cyclase
Definition
Catalyzes conversion of ATP to cAMP
Term
Protein kinase
Definition
enzyme that add phosphate groups to other proteins, opens ion channels
Term
Cocaine
Definition
Drug that affects are produced by binding to reuptake transporter for dopamine, resulting in overstimulation of neural pathways.
Term
Monoamine Oxidase
Definition
Enzyme that breaks down monoamines in presymaptic cell
Term
Dompaminergic neurons
Definition
Neurons that release dopamine
Term
Parkinson's disease
Definition
Second most common neurodegenerative disorder, degeneration of dopaminergic neurons in the motor areas of the brain. Too little dopamine
Term
L-dopa
Definition
Precursor to dopamine, given to parkinson's patients because dopamine doesn't cross the blood brain barrier
Term
Neuroleptic drugs
Definition
Antagonize dopamine receptors, for schizophrenia (too much dopamine)
Term
MAO inhibitors
Definition
Reduce activity of monoamine oxidase so less monoamines are broken down. Helps with depression and panic attacks. Side Effect-hypertensive crises. Eating foods rich in tyramine (cheese syndrome) may cause adverse reactions
Term
Selective Serotonin Reuptake Inhibitors
Definition
Inhibit serotonin transporters from taking out serotonin from synaptic cleft. Like Lexapro, prozac, paxil, and zoloft
Term
Tricyclic antidepressants
Definition
Older group of antidepressants, thought to interfere with reuptake of norepinephrine and sertonin, also have antihistamine and anticholinergic effects
Term
Cheyne-Stokes breathing
Definition
Ragged, stop and start breathing pattern that indicates a malfunction in brain stem
Term
Gamma hydroxybutyrate, G, Ecstasy, Georgia Home Boy, Cherry meth
Definition
Stimulant in small doses, binds to gaba receptors, large doses-lights out effect
Term
Neural tube
Definition
This is what the CNS begins as. Formed from the ectoderm (surface layer of embryonic tissue)
Term
Neural crest
Definition
This structrue ultimately forms the ganglia of PNS
Term
Telencephalon
Definition
Embryonic structure that becomes the cerebrum
Term
Diencephalon
Definition
Embryonic structure that becomes the Thalamus and hypothalamus
Term
Mesencephalon
Definition
Embryonic structure that becomes the midbrain
Term
Metencephalon
Definition
Embryonic structure that becomes the Pons and Cerebellum
Term
Myencephalon
Definition
Embryonic structure that becomes the Medulla oblongata
Term
Subventricular zone
Definition
Contains stem cells that divide to replenish themselves to produce new neurons and glial cells
Term
Subarachnoid space
Definition
contain CSF and surrounds brain and spoinal cord within meninges
Term
Spinal Tap/Lumbar Puncture
Definition
Withdraw small amount of CSF between L3 and L4
Term
Meningitis
Definition
Inflammation of the meninges caused by bacteria or viruses
Term
Hydrocephalus
Definition
caused by blockages to the flow of CSF, resulting build up of CSF increases intracranial pressure
Term
Electroencephalogram
Definition
Recording of the electrical currents in the brain
Term
Rapid Eye movement sleep
Definition
Part of sleep where dreams occur, EEG patters are desynchronized,sleep cycle lasts about 90 minutes
Term
Cerebrum
Definition
Largest portion of brain (80% of mass) has gray and white matter, responsible for sensory perception, motor control, language, emotion, and memory
Term
Corpus Callosum
Definition
Connect the two hemispheres of brain, tract of about 200 million axons
Term
Cerebral medulla
Definition
inner white matter of cerebrum
Term
Gyri
Definition
Elevated folds of brain's convolutions
Term
Sulci
Definition
Depressed grooves of the brain's convolutions
Term
Central Sulcus
Definition
Seperates Frontal and Parietal lobes
Term
Precentral gyrus
Definition
Anterior to the central sulcus, upper motor neurons, motor cortex
Term
Postcentral gyrus
Definition
Posterior to central sulcus, somatesthetic sensations, arising from skin, muscles, tendons, and joints
Term
Insula
Definition
Lobes not seen from surface, involved in interpreting smells and integrating sensations of pain
Term
Decussation
Definition
Axons crossing over from one side of the body to the other, most occer at level of medulla oblongata
Term
Cerebral Lateralization
Definition
Different hemispheres have different specializations
Term
Broca's Area/Aphasia
Definition
Left inferior frontal lobe, weakness in right arm, slow and poorly articulated speech, understand what is spoken
Term
Wernicke's aphasia/area
Definition
adjacent regions of parietal and temporal lobes, language comprehension is destroyed, words come out like mixed salad
Term
Limbic system
Definition
Includes hippocampus and amygdala, functions incl aggression, fear, sex, goal-directed behavior
Term
Alzheimers
Definition
Loss of neurons in hippocampus and cerebral cortex, accumulation of neurofibrillar tangles, accumulation of amyloid B-peptida in deposits called senile plaques
Term
Basal nuclei
Definition
Masses of gray matter that helps control body movements
Term
Corpus striatum
Definition
Most prominent structure of basal nuclei, collection of gray matter nuclei
Term
Substantia nigra
Definition
regulate activity of GABA releasing neurons in the basal nuclei, part of midbrain, when degraded produces parkinson's
Term
Thalamus
Definition
Relay center of brain, all sensory input except for smell passes through
Term
Hypothalamus
Definition
Controls pituitary gland, produces senstaion of thirst, thermostat, regulates sleep, contribute to sexual arousal
Term
Posterior Pituitary(Neurohypophysis
Definition
Formed from projection down of brain, secretes vasopressin and oxytocin, not produces-just secreted
Term
Anterior pituitary (adenohypophysis)
Definition
Not derived from neural tissue. Makes nad secretes TSH,FSH,LH,ACTH,GH, prolactin
Term
Suprachiasmatic nucei
Definition
located to left and right of hypothalamus, function as clock cells, regulate circadian rhythms
Term
Pineal gland
Definition
Where melatonin is secreted
Term
Nigrostriatal dopamine system
Definition
loss of neurons here causes parkinsons, travels from substantia nigra to basal nuclei
Term
Mesolimbic dopamine system
Definition
Participates in emotional reward. goes from midbrain to limbic system
Term
Nucleus accumbens
Definition
buried deep in frontal lobe, abused drugs promote the release of dopamine here
Term
Ataxia
Definition
Lack of coordination resulting from damage to the cerebellum
Term
Medulla Oblongata
Definition
Has vital centers including respiratory center, vasomotor center, and cardiac control center
Term
Hemiplegia
Definition
Motor difficulties on one side of body
Term
Lateral frontal area
Definition
People with damage here show lack of motivation and sexual desire and have defects in cognitive ability
Term
Orbitofrontal area
Definition
This area is required for pleasure and reward, receives input from all the senses and connection to the limbic system
Term
Mini Mental Status Exam
Definition
Test that takes a few minutes to test for dementia
Term
Supraoptic nucleus
Definition
A cluster of cells in the hypothalamus that releases vasopressin toward the end of the sleep period
Term
Organum vasculosum lamina terminalis
Definition
Senses loss of water and signal release of vasopressin and induces thirst
Term
Trigeminal neuralgia, tic douloureux
Definition
Caused by compression of the sensory axons in cranial nerve V just before it eneters the pons, causing action potentials in the sensory axons, common in middle aged and elderly people
Term
Bell's palsy
Definition
Most common cause of facial paralysis, cranial nerve VII, goes away after a few months
Term
Plexus
Definition
Axons from different levels of the spinal cord come together here, eg sciatic nerve, give rise to nerve that can be quite large
Term
Dorsal side of spinal cord
Definition
Sensory axons enter here
Term
Upper motor neurons
Definition
Stimulation of spinal motor neurons allows for motor control of these, association neurons in the motor areas of the brain
Term
Somatic motor neurons/lower motor neurons
Definition
spinal motor neurons that stimulate skeletal muscle, cell bodies in gray metter
Term
Dorsal root ganglia
Definition
neuron cell bodies of sensory neurons in a spinal nerve, bulge, pseudounipolar
Term
Monosynaptic muscle stretch reflex
Definition
Produces reflex arc, like knee-jerk reflex, sensory neuron synapes directly witht he somatic motor neuron
Term
Reflex arc
Definition
actions potentials arc into the spinal cord in the sensory neuron and out the motor neuron
Term
Muscle stretch receptor/muscle spindle
Definition
contains intrafusal fibers that are packaged together and attached to the tendons, stretched when muscle is stretched
Term
Spinal cord lesions
Definition
First produce spinal shock, then muscle spasticity, lack of GABA, baclogen helps
Term
Spinal shock
Definition
may last several weeks, temporary loss or reduction of spinal cord reflexes
Term
Baclofen
Definition
GABA derivative that can help reduce muscle spasms
Term
Golgi tendon organ
Definition
receptor that inhibits contraction of a muxcle when its tendons are under increased tension
Term
Reciprocal innervation
Definition
stiumlation of agonist with inhibition of antagonist muscle
Term
neuromuscular junction
Definition
synapse between somatic motor neuron adn skeletal muscle fiber
Term
End plate potential
Definition
what depolariztion is called in muscle fibers
Term
Collateral axon branches
Definition
end of somatic motor neuron produces these that synapse with different muscle fibers
Term
motor unit
Definition
collective name of somatic motor neuron and muscle fiber it innervates
Term
recruitment
Definition
The process of activatin more and larger motor units
Term
neuromuscular blocking drugs`
Definition
given before surgery to relax muscles, based on curare and block ACh from binding to receptors, atracurium, mivacurium, pancuronium
Term
Examples of neuromuscular blocking drugs
Definition
atracurium, mivacurium, pancuronium, succinyl-choline
Term
succinyl-choline
Definition
neuromuscular blocking drug that first causes depolarization and then blocks the ACh receptors
Term
Thoracolumbar division
Definition
Another name for hte sympathetic division of the autonomic nervous system, preganglionic neurons have cell bodies from t1 to L2
Term
Sympathetic chain of ganglia
Definition
Preganglionic axons synapse with the post ganglionic neruons on each side of the spinal cord here
Term
Collateral sympathetic ganglia
Definition
Associated with the digestive tract, some preganglionic neurons pass throught chain and synapse here
Term
Adrenal medulla
Definition
no ganglia or synapse here. derived from neural crest, preganglionic sympathetic axons synapse directly here
Term
Sympathoadrenal system
Definition
sympathetic division of ANS and adrenal medulla funtion together to be called this...
Term
Craniosacral division
Definition
Another name for the parasympathetic division of the ANS. Cell bodies reside in brain and sacral region
Term
terminal ganglia
Definition
synapes that are next to or within the organs they serve in the parasympathetic NS
Term
Ciliary ganglion
Definition
preganglionic parasympathetic axon of the oculomotor nerve synapse here, constrict iris,
Term
Autonomic dysreflexia
Definition
excessive activation of the sympathetic division below lesion, constriction of blood vessels in vescera and skin, elevate bp, results in flushing above lesion and painful headached
Term
cocaine
Definition
This drug block the reuptake of dopamine and norepinephrine, too much NT in cleft, when used in combination with alcohol more deadly
Term
sympathomimetic drug
Definition
drug that promotes sympathetic nerve effects, lead to increase in heart rate and constriction of coronary arteries
Term
B1- adrenergic receptors
Definition
In cardiac muscle cells, stimulate increased heart rate, antihypertensives can block this receptor
Term
B2-adrenergic receptors
Definition
Cells of the pulmonary airways that promote relaxation of smooth muscle, asthma treatment can stiumlate this receptor, dilation of skeletal muscle vessels
Term
a1-adrenergic receptors
Definition
stimulate contraction of vascular smooth muscle causing vasoconstriction, contraction of skeletal muscle vessels
Term
a2-adrenergic receptors
Definition
mostly found in presynaptic axon terminals, reduce activity of sympathoadrenal system, drugs that promote vasoconstriction stiumlate this
Term
Cholinergic symapses
Definition
synapses that use ACh as a neurotransmitter, can bind to nicotinic or muscarinic
Term
Atropine
Definition
Drug that inhibits parasympathetic effects. Blocks muscarinic ACh receptors. comes from belladonna, dilate pupils, help with peptic ulcers and irritable bowel syndrome, treat nerve gas exposure
Term
Albuterol
Definition
For treatment of asthma, Act on specific stimulators of B2 adrenergic receptors in the airways
Term
Salmeterol
Definition
Longer acting inhaled agonists of B2 adrenergic receptors in lungs
Term
Dobutamine
Definition
May be given intravenously to increase cardiac output and BP for shock, selective B1 adrenergic receptor
Term
Epinephrine
Definition
stimulates both a and B adrenergic receptors to treat cardiac arrest or anaphylactic shock
Term
Anaphylactic shock
Definition
Rapid fall in BP due to an excessive allergic reaction
Term
Atenolol, metoprolol
Definition
Block B1adrenergic receptors to treat hypertension
Term
norepinephrine
Definition
Acts on a adrenergic recepts and used to treat hypotension
Term
Midodrine
Definition
long actine a1 adrenergic receptor agonist for orthostatic/postural hypotension
Term
dihydroergotamine
Definition
stimulates a1 adrenergic receptors to cuase vasoconstiction of carotid artery to treat vascular and migraine headaches
Term
methysergide
Definition
inhibits serotonin to cause dilation of carotid artery branches, helps with headaches
Term
Clonidine
Definition
a2-adrenergic receptor in CNS that reduces overall sympathoadrenal activity, used for withdrawal
Term
nerve gas
Definition
tabun, sarin, inbibitors of AChE so ACh excessive stiumulation on all cholinergic synapses, treated with atropine
Term
Trismus
Definition
lockjaw, early sign of tetanus
Term
Risus sardonicus
Definition
telltale smile on tetanus victims, toxin has affected masseters
Term
bacillus clostridium tetani
Definition
excreted in the feces of animals, bacteria that causes tetany
Term
dystonia
Definition
movemetn disorder triggered by certain prescription drugs, diphenhydramine usual antidote
Term
strychnine
Definition
similar symptoms to tetanus
Term
chemoreceptors
Definition
receptors that respond to chemicals in the external environment and internal environment
Term
thermoreceptors
Definition
respond to cold and heat
Term
mechanoreceptors
Definition
respond to stimuli that deform the plams membrane, produce sensations of touch and pressure in the skin, also equilibrium nad hearing
Term
photoreceptors
Definition
respond to light, found in retina
Term
Nociceptors
Definition
pain receptors
Term
proprioceptors
Definition
receptors in muscles, joints, tendons, and ligaments
Term
Cutaneous receptors
Definition
sensory receptors in our skin
Term
Tonic receptors
Definition
receptors that respond continuously to stimulus
Term
phasic receptor
Definition
sensory adaptation, after a while we stop paying attention to constant stiumli
Term
cutaneous sensations
Definition
touch, pressure, heat, cold, and pain receptors in the skin. Heat cold and pain are just naked dendrites
Term
Ruffini endings/Merkel's discs
Definition
Special touch dendrites
Term
Meissner's corpuscles/Pacinian corpuscles
Definition
structures containing sensory dendrites sensative to pressure
Term
Capsaicin receptor
Definition
ion channel and receptor for capsaicin-hot temperatures
Term
Somatesthetic senses
Definition
sensations from cutanious receptors and proprioceptors
Term
Referred pain
Definition
like angina pectoris,signals get crossed
Term
phantom limb
Definition
70% of amputees have complete pain sensations 'arising' from the missing limb. The stump nerve ending generate action potentials. Also there is reorganization in the thalamus and postcentral gyrus.
Term
exteroceptor
Definition
responds to molecules from outside the body
Term
interoceptor
Definition
responds to molecules from inside the body
Term
taste cells
Definition
specialized epithelial cells inside barrel shaped taste buds. Long microvilli bathed in saliva
Term
five categories of taste
Definition
salty, sour, sweet, bitter, umami
Term
umami
Definition
savory, stimulated by amino acid glutamate
Term
salty
Definition
responds to Na+ ions
Term
sour
Definition
responds to H+ ions
Term
sweet, bitter, umami
Definition
specific receptor proteins
Term
olfaction
Definition
sense of smell, bipolar neurons in olfactory epithelium, sent directly to the medial temporal lobe, including the limbic system
Term
Gustatory sensation
Definition
Another name for taste sensation
Term
Bony labyrinth
Definition
Consists of cochlea and vestibular apparatus, filled with perilymph
Term
Vestibular apparatus
Definition
Consists of 3 semicircular canas, utricle and saccule
Term
Membranous labyrinth
Definition
located within bony labyrinth, filled with endolymph, contains hair cells
Term
stereocilia
Definition
hair like extensions in endolymph, mechanoreceptor
Term
kinocilium
Definition
large extension, like stereocilia, when stereocilia are ben towards this, plasma membrane is depolarized
Term
otolithic membrane
Definition
contians crystals of calcium carbonate,hair cells stick here in the utricle and saccule
Term
Utricle
Definition
Senses back and forth motion
Term
Saccule
Definition
Senses verticle motion, AP increased when accelerating downward
Term
Ampulla
Definition
swelling at base of each semicircular canal, contains cupula
Term
Cupula
Definition
hair cells project up in the endolymph of the membranous labyrinth and embed in this gelatinous membrane. inside ampulla, when this bends, the hairs cells inside it bend too
Term
vestibular nystagmus
Definition
involuntary oscillations of the eyes, like when you stop your spinning
Term
Meniere's disease
Definition
disease that can lead to degeneration of hair cells, tinnitus early symptom, vestibular nystagmus is one symptom
Term
tinnitus
Definition
inner ear ringing, like in meniere's disease.
Term
Tullios syndrome`
Definition
caused by superior canal dehiscence, vertigo and balance problems caused by sound
Term
Superior canal dehiscence
Definition
anatomical defect caused when portions of the temporal bone over the canal is thin or absent
Term
Pinna/Auricle
Definition
Names for outer ear that transmit sound waves to external auditory meatus
Term
Otitis externa
Definition
inflammation of the outer ear canal, like swimmer's ear
Term
Otitis media
Definition
inflammation of the middle ear
Term
auditory/eustachian tube
Definition
passageway from middle ear to nasopharynx, produces popping of ears to equalize pressure
Term
Apical surface
Definition
Top of cochlea
Term
Basal surface
Definition
Bottom of cochlea
Term
scala media/cochlear duct
Definition
membranous labyrinth in the cochlea
Term
scala vestibuli
Definition
upper compartment of sochlea
Term
scala tympani
Definition
lower compartment of cochlea
Term
tectorial membrane
Definition
gelatinous membrane of cochlea where the stereocilia of hair cells stick up into
Term
Spiral organ/organ of Corti
Definition
Structures of the cochlea that convert sound into action potentials
Term
benign paroxysmal positional vertigo
Definition
most common cause of positional vertigo, otoconia are dislodged
Term
otoconia
Definition
tiny chunks of calcium carbonate crystals in the ear
Term
Epley maneuver
Definition
standard treatment for BPPV, manipulate the head nad neck into certain postions to put otoconia back in place
Term
Conduction deafness
Definition
Damage to the tympanic membrane or middle ear ossicles, affects all frequencies, treated with hearing aids
Term
Sensorineural/perception deafness
Definition
occurs when transmission of impulses anywhere from cochlea to auditory cortex is impaired, results from pathological processes
Term
cochlear implants
Definition
device to help with sensorineural deafness
Term
Sclera
Definition
White part of eye
Term
Cornea
Definition
Made of transparent collagen fibers, in the eye
Term
Choroid
Definition
Middle, thin, darkly pigmented layer of eye, vascular, absorbs stray light rays
Term
Tapetum Lucidum
Definition
thin layer of reflective tissue within the choroid of cats and stuff
Term
Ciliary Body
Definition
Suspends the lens, attaches to it by suspensory ligament
Term
Anterior cavity of eye
Definition
In front of the lens
Term
Anterior chamber of anterior cavity
Definition
space between cornea and iris
Term
Posterior chamber of anterior cavity
Definition
space between iris and lens
Term
Posterior cavity
Definition
Behind the lens, has vitreous humor
Term
Aqueous humor
Definition
secreted by the ciliary body into the posterior chamber and passes through the pupil into the anterior chamber, drained by the canal of schlemm to venous blood,
Term
Canal of schlemm
Definition
returns aqueous humor to venous blood, blockage causes glaucoma
Term
Muscae volitantes/Floaters
Definition
Small bits of protein or cells floating in the vitreous humor, do not go away
Term
Posterior vitreous detachment
Definition
Membrane surrounding vitreous humor collapses inward and detaches from the retina
Term
Optic disc
Definition
Where the optic nerve leaves, blind spot
Term
Refraction
Definition
bending of light from one medium on another
Term
Crystallin
Definition
Proteins in cell cytoplasm of avascular lens
Term
Cataracts
Definition
damage from UV light, dehydration, oxidation cause crystallin proteins to change shape and produce cloudy patches in person's visual field, can surgically replace the lens
Term
Presbyopia
Definition
Increase in near point of vision, especially in elderly, decreased elasticity of lens
Term
visual acuity
Definition
refers to sharpness of vision
Term
Snellen eye chart
Definition
20/10 You see at 20 feet what a normal person can see at 10 feet
Term
myopia
Definition
nearsighted, correct with concave lens, eyeball too short
Term
hyperopia
Definition
farsighted, eyeball too long, correct with convex lenses
Term
astigmatism
Definition
eyeball not symmetric
Term
LASIK
Definition
laser-assisted in situ keratomileusis, reshape the cornea
Term
monovision
Definition
Make one eye undercorrected for reading and the other dominant for distance vision
Term
Rods
Definition
provide black and white vision, outside fovea
Term
Cones
Definition
Provide color vision, in fovea
Term
Retinal pigment epithelium
Definition
Where the tips of the outer segments of the rods and cones are embedded
Term
Rhodopsin
Definition
In the presence of light breaks down into retinal and opsin. Retinal goes from 11-cis with opsin to all-trans without opsin
Term
Dominant retinitis pigmentosa
Definition
mutant gene for opsin. C to A. Rods before cones. Lose periphery.
Term
Macular degeneration
Definition
Lose Central vision, degeneration of macula lutea
Term
Dichromats
Definition
People that only have two kinds of functioning cones
Term
Deuteranopia
Definition
Absence of green cones
Term
Protanopia
Definition
Absence of Red cones
Term
tritanopia
Definition
Loss of Blue Cones
Term
Fovea centralis
Definition
where we automatically adjust our eyes to focus, each cone has a direct line to the brain here, only has cones
Term
Macula lutea
Definition
Area around fovea centralis
Term
Angiogenesis
Definition
general name for growth of new blood vessels
Term
Neovascularization
Definition
growth of new blood vessels into a tissue
Term
Vascular endothelial growth factor
Definition
paracrine regulator that stimulates growth of blood vessels to a tumor
Term
Drusen
Definition
Differently colored dots that can be seen through an opthalamoscope, seen with macular degeneration
Term
Pancreatic islet/ islet of Langerhans
Definition
endocrine part of pancreas
Term
Catecholamines
Definition
Polar hormones, epinephrine and norepinephrine, secreted by the adrenal medulla
Term
Anabolic steroids
Definition
synthetic androgens that promote protein synthesis
Term
gynecomastia
Definition
male boobs
Term
tetraiodothyronine
Definition
T4/thyroxine, major thyroid hormone
Term
triiodothyronine
Definition
T3
Term
infundibulum
Definition
stalk that connects hypothalamus to the pituitary
Term
adenohypophysis
Definition
another name for the anterior pituitary
Term
Neurohypophysis
Definition
another name for the posterior pituitary
Term
Vasopressin
Definition
ADH, acts on kidneys to promote retention of water
Term
Oxytocin
Definition
pitocin, contracts uterus, contract mammary ducts,sexual arousal
Term
milk-ejection reflex
Definition
baby cry, milk shoot out, caused by oxytocin
Term
preeclampsia
Definition
pregnancy induced hypertension,induce birth by oxytocin injection
Term
hypothalamo-hypophyseal tract
Definition
goes between hypothalamus and posterior pituitary, axons
Term
neuroendocrine reflexes
Definition
Control the secretion of ADH and oxytocin
Term
Growth hormone, thyroid-stimulating, adrenocorticotropic, follicle-stimulating, luteinizing, prolactin
Definition
hormones secreted and produced by anterior pituitary
Term
Growth hormone
Definition
stimulates protein synthesis and promotes tissue and organ growth
Term
Thyroid stimulating hormone
Definition
stimulates thyroid to secrete T3 and T4
Term
Adrenocorticotropic hormone
Definition
stimulates adrenal cortex to secrete its corticosteroids like cortisol
Term
follicle stimulating hormone
Definition
stiumlates the growth of ovarian follicles in women and sperm in men
Term
luteinizing hormone
Definition
stimulates formation of corpus luteum (F) and leydig cells to secrete testosterone (M)
Term
gonadotropic hormones
Definition
LH and FSH are.....
Term
Prolactin
Definition
stimulates milk prodution after baby is born
Term
hypothalamo-hypophyseal portal system
Definition
system of blood vessels at the base of the hypothalamus that is drained into venules that carry blood to anterior pituitary
Term
pituitary dwarfism
Definition
Too little GH in childhood
Term
pituitary cachexis/Simmonds' disease
Definition
too little GH in adults
Term
gigantism
Definition
too much GH in childhood
Term
acromegaly
Definition
too much GH in adulthood
Term
Corticotropin releasing, thyrotropin releasing, gonadotropin releasing, growth hormone releaseing, somatostatin, prolactin inhibiting
Definition
Examples of hypothalamic regulatory hormones
Term
corticotropin-releasing hmo
Definition
stimultes AP to secrete adrenocorticotropic hormone
Term
Thyrotropin-releasing hormone
Definition
stimulates AP to secrete thyroid-stimulating hormone
Term
gonadotropin releasing hormone
Definition
stimulates AP to secrete both gonadotropics (FSH and LH)
Term
Somatostatin
Definition
inhibits AP from secreting growth hormone
Term
growth hormone releasing hormone
Definition
stimulates AP to secrete GH
Term
Prolactin inhibiting hormone
Definition
ingibits AP from secreting prolactin
Term
pituitary-gonad axis
Definition
negative feedback system, hypothalamus secretes GnRH, AP secretes GSH and LH,gonads secrete sex hormones which inhibit secretion of FSH and LH and GnRH
Term
Cushing's syndrome
Definition
oversecretion of corticosteroids, moon face, buffalo hump
Term
Addison's disease
Definition
too little corticosteroids, electrolyte imbalances and dehydration, JFK had it
Term
Prednisolone, dexamethasone
Definition
glucocorticoids, immunosuppressants, supress secretion of ACTH, taper off
Term
cyclic AMP
Definition
second messenger used by epinephrine
Term
Three types of corticosteroids
Definition
glucocorticoids, mineralocorticoids, weak androgens
Term
glucocorticoids
Definition
regulate metabolism to reaise blood glucose concentration (glycogenolysis but more of gluconeogenesis)
Term
corticosteroids
Definition
steroid hormones secreted by the adrenal cortex, nonpolar
Term
mineralcorticoids
Definition
regulates mineral and electrolyte concentrations in the blood, like aldosterone
Term
weak androgens
Definition
androstenedione, testosterone
Term
Nuclear receptors
Definition
receptor proteins for nonpolar steroid and thyroid hormones because they are inside the cells
Term
General adaptation syndrome
Definition
increase in cortisol in response to stress, can repair stuff
Term
aldosterone
Definition
stimulates the kidneys to retain more Na and water to not be hypotensive and also to excrete more K
Term
angiotensin II
Definition
chemical regulator that is produces when there is a fall in blood volume and pressure
Term
thyroid follicles
Definition
water balloon like structures filled with colloid, combines iodine with thyroglobulin
Term
thyroglobulin
Definition
precursor or T4 and T3, combines with iodine in the colloid
Term
colloid
Definition
protein rich fluid in the thyroid follicles
Term
thyroxine binding globulin
Definition
blood carrier that transports nonpolar T4
Term
grave's disease
Definition
goiter caused by stimulation of the thyroid by autoantibodies
Term
exophthalmos
Definition
bulging eyes
Term
cretinism
Definition
low thyroxine, severe mental retardation, babies
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