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Test 1
Endomembrane, cytoskeleton and Energy
110
Other
Undergraduate 4
02/23/2017

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Term
Heterochromatin
Definition
Condensed DNA
Term
Euchromatin
Definition
Loose DNA
Term
Carbon
Definition
4 carbon bonds making it the molecule of life
Term
H2O
Definition
Excellent solvent, high boiling point, high heat capacity, high heat of vaporization, high surface tension, ice floats
Term
Classes of macromolecules
Definition
Carbohydrates, lipids, nucleic acid, proteins
Term
Carbohydrates
Definition
Simple sugar, monomers --> polymers, glucose
Term
Glycogen chain number
Definition
alpha 1-4 , and branch points alpha 1-6
Term
GAGs
Definition
Glycosaminoglycans
Term
Lipids
Definition
Hydrophobic, and insoluble in H2O
Term
Fatty acid chain
Definition
Repeating carbohydrate group, triglycerides are neutral fats
Term
Saturated
Definition
Single bonds, linear
Term
Unsaturated
Definition
Double/triple bonds, bent
Term
Phospholipids
Definition
Polar, bilayer, thickness is 8 nm
Term
Phosphoglycerides
Definition
Have glycerol
Term
Sphingolipids
Definition
Have sphingosine
Term
Amino acids
Definition
20 types, hydrolysis
Term
Cell membrane
Definition
Barrier (semipermeable), cell recognition (transportation), receptors (proteins)
Term
Cell membrane strcture
Definition
Phospholipid bilayer, 8-10 nm
Term
Discovered protein and phospholipid bilayer
Definition
Davson and Danielli 1935
Term
Discovered unit membrane
Definition
Robertson 1960
Term
Unit membrane
Definition
Thin sheetlike structure made of 4 continuous monolayers of molecules
Term
Discovered fluid mosaic model
Definition
Singer and Nicolson 1972
Term
Fluid Mosaic Model
Definition
Cell membrane as a two-dimensional liquid that restricts the lateral diffusion of membrane components
Term
Parts of phospholipid bilayer
Definition
Glycolipids/glycoproteins, phospholipid translocated (flipase), Cholesterol
Term
Cholesterol
Definition
Storage, decrease permeability to ions, stability
Term
Polkilotherms
Definition
Cold blooded animals, change lipids in membrane
Term
Proteins
Definition
Channel, receptor, transport, enzymes
Term
Lipid raft
Definition
1-2 nm, glycosphingolipids (receptor proteins located in region), lots of cholesterol
Term
Diffusion across membrane
Definition
Not ions, yes steroids, osmosis
Term
Brownian motion
Definition
Movement from high to low concentration
Term
Facilitated transport
Definition
Requires protein
Term
Two types of facilitated transport
Definition
Channel and Transports
Term
Channel
Definition
Ions (charge), porins (Large open channel), aqua porins (channel for H2O)
Term
Transporters
Definition
High to low concentration, specificity
Term
Examples of transporters
Definition
Glut 1 --> Attach, conformational change, glucose delivered

Glut 2 --> Phosphate attached (keeps glucose in cell)

Anion exchange --> CO2 goes in, HCO3- goes out, Cl- goes in
Term
Antiport
Definition
Channel lets things go in and out
Term
Symport
Definition
Channel lets things go either in or out
Term
Ligand gated channel
Definition
Attachment site for molecules
Term
Voltage gated channel
Definition
Gate opens based on voltage across membrane
Term
P face
Definition
Layer on inside
Term
E face
Definition
layer on outside
Term
Active transport
Definition
Protein required, direct and indirect
Term
Direct transport
Definition
Energy in form of ATP, P-pumps (ATP
Term
Indirect
Definition
Coupled to ion flow
Term
Examples of direct transport
Definition
Na+/K+ pump --> K+ goes in and Na+ goes out

Ca++ pump --> smooth ER, v-pump
Term
F-pump
Definition
Cristae (ATP synthase), bacterial membranes, Thylaloid, phosphorylate (ATP to ADP)
Term
Base of transporters
Definition
Ankyran, spectrin, actin and tropomyosin
Term
Endoplasmic Reticulum
Definition
5-6 nm
Term
Free ribosomes (polyribosomes)
Definition
Signal to either make protein or go to ER, free post-transitional import
Term
SER funciton
Definition
Synthesis, calcium storage, carbohydrate metabolism, drug detoxification
Term
RER
Definition
Autoradiology, radioactive labeled proteins track glycoprotein
Term
Cis (CGN)
Definition
Outside fold of Golgi
Term
Trans (TGN)
Definition
Inside fold of Golgi
Term
Primary lysosome
Definition
Hasn't absorbed anything
Term
Secondary lysosomes
Definition
Absorbed things
Term
Lipofusion
Definition
Irregular lysosome
Term
Constitutive
Definition
Can excrete without receptor
Term
Regulated
Definition
Receptors on outside creating trigger
Term
Medial cisternae
Definition
Middle part of the Golgi
Term
Maturational
Definition
Moves to create layers, moving CGN-->TGN
Term
Stationary
Definition
The Golgi doesn't move
Term
Coated Vesicles
Definition
Mediate vesicular transport of cargo between organelles in the post Golgi network
Term
Example of coated vesicle
Definition
Clathrin --> between cell membrane and TGN
Term
COP2
Definition
CGN --> medial --> TGN
Term
COP1A
Definition
TGN --> medial --> CGN
Term
COP1B
Definition
Between the medials
Term
Anterograde
Definition
RER --> CGN --> TGN
Term
Retrograde
Definition
TGN --> CGN --> RER
Term
Early endosomes
Definition
pH 7, closest to membrane
Term
Late endosomes
Definition
pH 5, have 40 hydorlytic enzymes
Term
Microsomal fraction
Definition
mix RER, SER, and Golgi
Term
Discovered the lysosome, equilibrium density and peroxisome
Definition
Christian de Duve 1950
Term
Lysosome function
Definition
Autophagy, WBCs phagocytosis, autolysis (apoptosis), Acrosome
Term
Mannose-6-phosphate
Definition
Phosphorylated marker to go to lysosome
Term
Acrosome
Definition
TGN cap on sperm delivered by Golgi
Term
Endocytosis
Definition
Releasing things from the cell
Term
Exocytosis
Definition
Taking things into the cell
Term
Example of receptor mediated endocytosis
Definition
Low density lipoprotein
Term
Example of lysosomal storage diseases
Definition
Type 2 glycogenosis --> lack of glucosidase

Tay Sachs Disease --> enzyme x gangliocides myelin
Term
Peroxisomes
Definition
Large 1 nm (liver kidneys)

Microperox .2 nm (steroid cells)

Perox reticulum
Term
Thin filaments
Definition
5-7 nm, actin (globular- g-actin) (filiment- f-actin)
Term
Intermediate filaments
Definition
10-25 nm
Term
Think filament
Definition
Only found in muscles
Term
Plus end
Definition
Growth or degeneration
Term
Minus end
Definition
No growth
Term
Centriole
Definition
9 triplets of MTs at right angle
Term
MToC
Definition
MT organizing center
Term
Chemicals disrupt MTs
Definition
Colchine and nocodazole
Term
Cause aggregation MTs
Definition
Taxol and vinblastine
Term
MT associated proteins (MAP)
Definition
Motor and nonmotor
Term
Motor MAP
Definition
Myosin 2 --> moves down thick filament

Kinase --> moves toward positive end

Dynein --> moves toward minus end
Term
Nonmotor MAP
Definition
Tau protein --> bundles MTs cause Tau proteins to hold together
Term
Types of tissues and intermediate filaments
Definition
Epithelial --> Keratin
Connective --> Vimentin
Muscular --> Desmin
Nervous --> Neurofilament and GFAP (glial fibulary acidic protein)
Term
Carcinoma tumor
Definition
Tumor from epithelial tissue
Term
Sarcoma
Definition
Tissue from connective and muscular tissue
Term
Microtubules
Definition
Thin, intermediate, think
Term
Isoforms
Definition
Alpha skeletal muscle
Nonmuscle- beta and gamma
Term
Enzymes
Definition
Lower activation energy
Term
Glycolytic pathway
Definition
Glycolysis, main anaerobic pathway
Term
Anabolic
Definition
Builds up
Term
Catabolic
Definition
Breaks down
Term
Aerobic
Definition
With oxygen
Term
Anaerobic
Definition
Without oxygen
Term
Glycolysis
Definition
Glu-6
Glu-6-Phosphate
Fructose-6-phosphate
Fructose-1,6-diphosphate

Pyruvate
Term
Enzyme that makes acetyl CoA
Definition
pyruvate dehydrogenase
Term
Purpose of CAC
Definition
electron and proton carriers

3 NAD
1FADH
Term
Discovered the CAC
Definition
Leininger and Kennedy 1950
Term
First micrograph taken
Definition
1952-1953
Term
Princes paper on mitochondria
Definition
1999
Term
Discovered particles on cristae
Definition
Fernandez Moran 1970
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