Shared Flashcard Set

Details

Test 1
Lecture 1-10, 16
99
Health Care
Undergraduate 3
02/12/2014

Additional Health Care Flashcards

 


 

Cards

Term
55-70
Definition
Relative Range for Neutrophils
Term
0-7
Definition
Relative Range for Bands
Term
25-40
Definition
Relative Range for Lymphs
Term
3-7
Definition
Relative Range for Monos
Term
1-3
Definition
Relative Range for Eos
Term
0-1
Definition
Relative Range For Baso
Term
4,500-11,000/ul
Definition
WBC Range
Term

((#particles*dilution factor)

(area mm*unit ov volume (.1mL))

Definition
Hemocytometer equation
Term
Neutropenia
Definition
<55% Neutrophils
Term
Neutrophilia
Definition
>70% Neutrophils
Term
Lymphocytosis
Definition
>40% Lymphs
Term
Lymphocytopenia
Definition
<25% Lymphs
Term
Left shift
Definition
Increase in immature neutrophils
Term
(Extramedullary) Hematopoiesis and linking together nerves, capillaries, blood, lymphatics
Definition
BM Function
Term
Yellow Marrow
Definition
fat cells (lipocytes)- can convert to hematopoietic cells
Term
Red Marrow
Definition
Hematopoietic cells
Term

50:50 Fat:Cells

fat increases in age

cells decrease in age

Definition
BM cellularity for an average adult
Term
20 mg
Definition
Daily iron amount needed
Term
Fe3+
Definition
Iron is transported in what state
Term
Transferrin
Definition
Transport of Absorbed Iron
Term
Ferritin
Definition

Storage form of iron

BM, spleen, liver

Term
Hemosiderin
Definition
2nd Storage form of Iron
Term

Hgb ~65%

Ferritin/hemosiderin ~30%

Definition
Top 2 locations of Body Iron
Term
Serum Iron
Definition

Limited use as a single measurement

 

Term
TIBC (Total Iron Binding Capability)
Definition

Indirect measurement of transferrin

 

Term
% Saturation of Transferrin
Definition

(Serum iron/TIBC) * 100%

increased in iron overload

Term
Hereditary Hemochromatosis
Definition
Iron overload disorder
Term
Mitochondria
Definition

Where does Heme Synthesis occur?

 

Term
Porphyrin
Definition
Defective enzyme in heme synthesis
Term
Ribosomes
Definition
Where does globin chain synthesis occur?
Term
Directly related
Definition
How is the rate of globin synthesis related to the rate of porphyrin synthesis?
Term
Right shift
Definition

Dissociation curve

Lower affinity for oxygen

Increased oxygen tissue delivery

Term
Left shift
Definition

Oxygen dissociation curve

Higher affinity for oxygen

Decreased oxygen tissue delivery

Term
Measured
Definition

Measured or derived?

MCV

Term
Derived
Definition

Measured or derived?

MCH

Term
Derived
Definition

Measured or derived?

MCHC

Term
derived
Definition

Measured or derived?

RDW

Term
RNA
Definition
What are retics composed of?
Term
BM, fetal liver, and thymus
Definition
Primary Lymphoid organs
Term
Lymph nodes, spleen, MALT
Definition
Secondary Lymphoid organs
Term
T cells
Definition
Which is long lived, T or B cells?
Term
B Cells
Definition
Which produce antibodies, T or B cells?
Term
T cells
Definition

Which ones function is regulatory and effector?

T or B Cell

Term
Viral infections
Definition
Main cause of Lymphocytosis?
Term

Aplastic anemia

Therapies

Definition
Reasons for Lymphocytopenia
Term
[image]
Definition
Write out stages of Erythropoiesis, both
Term

Polychrom. normoblast

Rubricyte

Definition
Last RBC stage to divide
Term

Polychrom. RBC

Diffusely Basophilic Erythrocyte

Definition
Last stage to produce Hgb
Term
[image]
Definition

RBC Maturation

Whats in BM?

Whats in Blood?

Whats capable of division?

Whats unable to divide?

Term
Microcytosis
Definition

problems in Hgb synthesis

increase in cellular division

Term
Macrocytosis
Definition

Impaired DNA synthesis

decrease in cellular division

Term

Compensating

Post hemorrhage

Hemolytic Anemia

Responding to Rx

Definition
RPI >2
Term

Not compensating

Hypoproliferation

Ineffective hematopoeisis

Aplastic Anemia

Definition
RPI <2
Term

Loses Flexibilty

Decreases in

-enzyme activity

-decreased ATP

-K

-MCV

-water

Definition

Age dependant changes

Flexibility?

Decreases in?

Term

Increases in

-Na

-MCHC

-O2 affinity

Definition

Age Dependent Changes

Increases in?

Term

Extravascular (outside of circulation)

Intravascular (within the circulation)

Definition
2 types of RBC Catabolism
Term
Extravascular
Definition
90% of catabolism
Term

RES (macrophages)

MPS (macrophages)

Lymphatics (production of immunoglobin)

Old folks home (old cells removed)

Beauty Salon (remove inclusions or damaged)

Nursery (retics are larger and less flexible)

Storage Site (20-30% stored, gran storage, young RBCs)

Definition
Spleen Functions
Term

Cell is phagocytized by macrophage

 

Definition
1st step in Extravascular RBC catabolism
Term
Heme and Globin
Definition
In EV RBC catabolism, Hgb is broken down into
Term
Iron, CO, and Biliverdin
Definition
In EV RBC catabolism, heme is broken down into
Term
Bilirubin
Definition
In EV RBC catabolism, biliverdin is converted to
Term
Unconjugated is water insoluble and needs to be converted to be excreted
Definition
Difference between Pre-hepatic or unconjugated bilirubin and conjugated bilirubin?
Term

Iron goes into storage pool to be reused (hemosiderin)

Globin is broken down into aa and goes into pool

Definition
What happens to Iron and Globin after EV RBC catabolism
Term

Hgb bins to Haptoglobin

Hgb-Haptoglobin travels to liver

Hgb not bound to haptoglobin converts to Methemoglobin (Fe3+ oxidized)

Methemeglobin--> Metheme + globin

Globin goes to aa pool

Definition
What happens in IV RBC catabolism
Term
It is not recycled like it is in EV RBC catabolism
Definition
What happens to Iron in IV RBC catabolism
Term

Myeloblast

Promyelocyte

Myelocyte

Metamyelocyte

Band

Neutrophil

Definition
Stages of Neutrophil
Term

Promyelocyte- primary(azurophilic)

Myelocyte- secondary

Definition
Where granules appear in neutrophil maturation
Term
secondary (red) granules
Definition
Type of granules Eosinophils have
Term
secondary (purple-nlack granules)
Definition
Type of granules Basophils have
Term
Marginal Pool + Circulating Pool
Definition
What makes up total circulating granulocyte pool?
Term

Infections

Stress

Hematologic disorders

Tissue Breakdown

Drugs toxins

Leukemoid reaction

Definition
Neutrophilia is caused by
Term
Histaminiase
Definition
Eosinophil granules contain
Term
to engulf and kill microorganisms
Definition
Neutrophil functions
Term
Allergies and parasitic infections
Definition
Eosiniphilia caused by
Term
Allergy or inflammation
Definition
Basophilila caused by
Term
Histamine and Heparin
Definition
Basophil granule content
Term

Phagocytosis and digestion

Processantigens for presentation to immune system

Definition
Monocyte functions
Term
Size of cells (RBCs, Platelets, and WBCs)
Definition
Histograms is a displayed result of what being analyzed?
Term
36-360fL
Definition
Range of RBC Histogram
Term
would appear in the beginning of an RBC and end of a platelet
Definition
Shistocytes would appear where on an RBC histogram and Platelet histogram
Term
2-20fL
Definition
range of a platelet histogram
Term
Lymphs, monos, granulocytes
Definition
Order of a WBC histogram
Term

Fibrin strains

big platelets

nRBCs

Definition
Appears at the start of a WBC histogram, before the lymphs?
Term
Size x Complexity
Definition

What is on a WBC Scatterplot?

Verticle X Horizontal

Term

RBC- low

MCHC-high

MCH-?

MCV-high

HCT- low

Hgb- Nothing

Definition

What happens in Cold Agglutination

RBC-

MCHC-

MCH-

MCV-

HCT-

Hgb-

Term
ALA synthetase
Definition
Control the major rate limiting step in heme synthesis
Term

pH increases

DBG decreases

Temp decreases

p50 decreases

Definition

left shift

pH

DPG

Temp

p50

Term
Basophilic Stippling
Definition

Abnormal aggragates of RNA and mitochondrial remnants

Fault or accelerated heme synthesis

Term
Howell-Jolly Bodies
Definition

Small, round inclusion

Composed of DNA

Term
Peppenheimer Bodies
Definition

Abnoral aggregates of iron packed in micelles of swollen mitochondria

Caused by faulty incorporation of iron into heme

Sideroplastic anemia

Term
siderocyte
Definition

singleor multiple turquiose granules

Composed of ferritin (non-heme iron)

Term
Heinz Bodies
Definition

-Blue/purple aggregates clining to cell membrane

-Composed of Hgb precipitating after heme globin dissociates

Term
metamyelocytes and bands
Definition
Whats in maturation pool
Term
Stem cells, myeloblasts, promeylocytes, and myelocytes
Definition
What stages of neutrophils are in the maturation pool
Term

MPO myeloperoxidase

4.0 pH

Definition
What are neutrophil Primary granules (azurophilic or nonspecific) granules made of
Term
Monocytes
Definition
Process antigens for presentation to immune system
Term
Index of iron stores
Definition
Serum Ferritin
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