Term
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Definition
| Relative Range for Neutrophils |
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Term
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Definition
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Term
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Definition
| Relative Range for Lymphs |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
((#particles*dilution factor)
(area mm*unit ov volume (.1mL)) |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| Increase in immature neutrophils |
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Term
| (Extramedullary) Hematopoiesis and linking together nerves, capillaries, blood, lymphatics |
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Definition
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Term
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Definition
| fat cells (lipocytes)- can convert to hematopoietic cells |
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Term
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Definition
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Term
50:50 Fat:Cells
fat increases in age
cells decrease in age |
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Definition
| BM cellularity for an average adult |
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Term
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Definition
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Term
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Definition
| Iron is transported in what state |
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Term
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Definition
| Transport of Absorbed Iron |
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Term
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Definition
Storage form of iron
BM, spleen, liver |
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Term
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Definition
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Term
Hgb ~65%
Ferritin/hemosiderin ~30% |
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Definition
| Top 2 locations of Body Iron |
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Term
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Definition
Limited use as a single measurement
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Term
| TIBC (Total Iron Binding Capability) |
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Definition
Indirect measurement of transferrin
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Term
| % Saturation of Transferrin |
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Definition
(Serum iron/TIBC) * 100%
increased in iron overload |
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Term
| Hereditary Hemochromatosis |
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Definition
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Term
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Definition
Where does Heme Synthesis occur?
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Term
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Definition
| Defective enzyme in heme synthesis |
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Term
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Definition
| Where does globin chain synthesis occur? |
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Term
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Definition
| How is the rate of globin synthesis related to the rate of porphyrin synthesis? |
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Term
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Definition
Dissociation curve
Lower affinity for oxygen
Increased oxygen tissue delivery |
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Term
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Definition
Oxygen dissociation curve
Higher affinity for oxygen
Decreased oxygen tissue delivery |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Measured or derived?
MCHC |
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Term
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Definition
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Term
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Definition
| What are retics composed of? |
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Term
| BM, fetal liver, and thymus |
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Definition
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Term
| Lymph nodes, spleen, MALT |
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Definition
| Secondary Lymphoid organs |
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Term
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Definition
| Which is long lived, T or B cells? |
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Term
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Definition
| Which produce antibodies, T or B cells? |
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Term
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Definition
Which ones function is regulatory and effector?
T or B Cell |
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Term
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Definition
| Main cause of Lymphocytosis? |
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Term
Aplastic anemia
Therapies |
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Definition
| Reasons for Lymphocytopenia |
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Term
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Definition
| Write out stages of Erythropoiesis, both |
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Term
Polychrom. normoblast
Rubricyte |
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Definition
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Term
Polychrom. RBC
Diffusely Basophilic Erythrocyte |
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Definition
| Last stage to produce Hgb |
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Term
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Definition
RBC Maturation
Whats in BM?
Whats in Blood?
Whats capable of division?
Whats unable to divide? |
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Term
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Definition
problems in Hgb synthesis
increase in cellular division |
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Term
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Definition
Impaired DNA synthesis
decrease in cellular division |
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Term
Compensating
Post hemorrhage
Hemolytic Anemia
Responding to Rx |
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Definition
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Term
Not compensating
Hypoproliferation
Ineffective hematopoeisis
Aplastic Anemia |
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Definition
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Term
Loses Flexibilty
Decreases in
-enzyme activity
-decreased ATP
-K
-MCV
-water |
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Definition
Age dependant changes
Flexibility?
Decreases in? |
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Term
Increases in
-Na
-MCHC
-O2 affinity |
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Definition
Age Dependent Changes
Increases in? |
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Term
Extravascular (outside of circulation)
Intravascular (within the circulation) |
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Definition
| 2 types of RBC Catabolism |
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Term
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Definition
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Term
RES (macrophages)
MPS (macrophages)
Lymphatics (production of immunoglobin)
Old folks home (old cells removed)
Beauty Salon (remove inclusions or damaged)
Nursery (retics are larger and less flexible)
Storage Site (20-30% stored, gran storage, young RBCs) |
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Definition
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Term
Cell is phagocytized by macrophage
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Definition
| 1st step in Extravascular RBC catabolism |
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Term
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Definition
| In EV RBC catabolism, Hgb is broken down into |
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Term
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Definition
| In EV RBC catabolism, heme is broken down into |
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Term
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Definition
| In EV RBC catabolism, biliverdin is converted to |
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Term
| Unconjugated is water insoluble and needs to be converted to be excreted |
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Definition
| Difference between Pre-hepatic or unconjugated bilirubin and conjugated bilirubin? |
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Term
Iron goes into storage pool to be reused (hemosiderin)
Globin is broken down into aa and goes into pool |
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Definition
| What happens to Iron and Globin after EV RBC catabolism |
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Term
Hgb bins to Haptoglobin
Hgb-Haptoglobin travels to liver
Hgb not bound to haptoglobin converts to Methemoglobin (Fe3+ oxidized)
Methemeglobin--> Metheme + globin
Globin goes to aa pool |
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Definition
| What happens in IV RBC catabolism |
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Term
| It is not recycled like it is in EV RBC catabolism |
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Definition
| What happens to Iron in IV RBC catabolism |
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Term
Myeloblast
Promyelocyte
Myelocyte
Metamyelocyte
Band
Neutrophil |
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Definition
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Term
Promyelocyte- primary(azurophilic)
Myelocyte- secondary |
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Definition
| Where granules appear in neutrophil maturation |
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Term
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Definition
| Type of granules Eosinophils have |
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Term
| secondary (purple-nlack granules) |
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Definition
| Type of granules Basophils have |
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Term
| Marginal Pool + Circulating Pool |
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Definition
| What makes up total circulating granulocyte pool? |
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Term
Infections
Stress
Hematologic disorders
Tissue Breakdown
Drugs toxins
Leukemoid reaction |
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Definition
| Neutrophilia is caused by |
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Term
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Definition
| Eosinophil granules contain |
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Term
| to engulf and kill microorganisms |
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Definition
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Term
| Allergies and parasitic infections |
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Definition
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Term
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Definition
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Term
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Definition
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Term
Phagocytosis and digestion
Processantigens for presentation to immune system |
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Definition
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Term
| Size of cells (RBCs, Platelets, and WBCs) |
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Definition
| Histograms is a displayed result of what being analyzed? |
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Term
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Definition
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Term
| would appear in the beginning of an RBC and end of a platelet |
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Definition
| Shistocytes would appear where on an RBC histogram and Platelet histogram |
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Term
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Definition
| range of a platelet histogram |
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Term
| Lymphs, monos, granulocytes |
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Definition
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Term
Fibrin strains
big platelets
nRBCs |
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Definition
| Appears at the start of a WBC histogram, before the lymphs? |
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Term
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Definition
What is on a WBC Scatterplot?
Verticle X Horizontal |
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Term
RBC- low
MCHC-high
MCH-?
MCV-high
HCT- low
Hgb- Nothing |
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Definition
What happens in Cold Agglutination
RBC-
MCHC-
MCH-
MCV-
HCT-
Hgb- |
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Term
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Definition
| Control the major rate limiting step in heme synthesis |
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Term
pH increases
DBG decreases
Temp decreases
p50 decreases |
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Definition
left shift
pH
DPG
Temp
p50 |
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Term
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Definition
Abnormal aggragates of RNA and mitochondrial remnants
Fault or accelerated heme synthesis |
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Term
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Definition
Small, round inclusion
Composed of DNA |
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Term
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Definition
Abnoral aggregates of iron packed in micelles of swollen mitochondria
Caused by faulty incorporation of iron into heme
Sideroplastic anemia |
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Term
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Definition
singleor multiple turquiose granules
Composed of ferritin (non-heme iron) |
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Term
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Definition
-Blue/purple aggregates clining to cell membrane
-Composed of Hgb precipitating after heme globin dissociates |
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Term
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Definition
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Term
| Stem cells, myeloblasts, promeylocytes, and myelocytes |
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Definition
| What stages of neutrophils are in the maturation pool |
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Term
MPO myeloperoxidase
4.0 pH |
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Definition
| What are neutrophil Primary granules (azurophilic or nonspecific) granules made of |
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Term
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Definition
| Process antigens for presentation to immune system |
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Term
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Definition
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