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Test 1 Receptors
Receptor Pathways
8
Pharmacology
Undergraduate 4
02/16/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Where are M2 and M3?
Definition
M2 heart

M3 bladder/GI
Term
M2
Definition
Gi -> inhibit AC -> cAMP -> PKA -> Ca++ -> decreased contraction (heart) -> decrease BP and cardiac output
Term
M3
Definition
Gq -> activate PLC -> DAG/IP3 -> PKc -> Ca++ -> increased contraction (bladder/GI) -> increase GI motility
Term
Where are a1, a2, b1, and b2?
Definition
a1 vessels
a2 presynaptic neuron
b1 heart
b2 vessels and bronchioles
Term
a1
Definition
Gq -> activate PLC -> DAG/IP3 -> PKc -> Ca++ -> increased contraction (vessels) -> increase BP
Term
a2
Definition
(negative feedback) decrease NE release -> inhibit vasocontriction (vasodilate)

*note = inhibits insulin release
Term
b1
Definition
Gs -> activate AC -> cAMP -> PKA -> Ca++ -> increased contraction (heart) -> increase BP and cardiac output
Term
b2
Definition
Gs and Gi

Gs (Gi) -> AC -> cAMP -> PKA -> Ca++ -> decreased contraction (vessels/bronchi) -> vasodilation/bronchodilation

*note = increase glucose levels
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