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Term 1, Biochem Lecture #12
Intro to Metabolism
11
Medical
Graduate
09/11/2009

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Term

Standard conditions for Gibbs free energy change

Definition

T=298K, P=1atm (760mm Hg), 1M of reactants and products

Term

Equ for Gibbs free energy at standard conditions

Definition

ΔG°= (-2.3)(RT)log Keq = -(RT)Keq

Term

Differences between ΔG° and ΔG

Definition

ΔG is the actual free energy change for a rxn under cellular conditions

Term

Eqn for the actual free energy change

Definition

ΔG = ΔG° + {(RT) ln[products/reactants]}

Term

Two examples of energy-rich compounds that release a large amount of energy when hydrolyzed

Definition

Thioesters and Phosphate compounds are examples of these

Term

Two important thioester compounds

Definition

Acetyl-Coa and Succinyl-CoA are to examples of this

Term

Two examples of high-energy phosphate compunds in muscle

Definition

Phosphagens and Creatine phosphate are two examples of these

Term

Fxn of Adenylate kinase

Definition

It is responsible for getting AMP back into the ADP/ATP cycle by using ATP to convert AMP into 2ADPs

Term

Importance of rxn coupling

Definition

The first rxn is exergonic and some its free energy is used to drive the 2nd endergonic rxn

Term

Two ways to generate ATP in the cell

Definition

Oxidatove phosphorylation in the ETC and substrate level phosphorylation where metabolites with higher group potential phosporylate ADP

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