Term
| Which drug can be used both for TB and Leprosy? |
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Definition
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Term
|
Definition
- Inhibit mycolic acid biosynthesis
- Analog of B3
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Term
|
Definition
- Suppress RNA synthesis
- Drug-enzyme complex
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Term
|
Definition
- converted to POA. ↓PH = less growth
The pirates make acid |
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Term
| Which drug causes red color excretions? |
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Definition
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Term
| Which drug causes optic neuritis? (reversible) |
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Definition
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if you keep drinking all that ethanol, you'll go blind
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Term
| Which TB drug can raise uric acid levels? |
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Definition
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making more acid causes buildup of uric acid
pirates make you walk the plank into acid
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Term
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Definition
- Binds DNA inhibits growth
throw a cloth over him, so he can't expand |
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Term
| Drug that causes pink/brown skin |
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Definition
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Makes you look like you are wearing colored cloths
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Term
| 6-month treatment plan for TB |
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Definition
- Isoniazid + Rifampin + pyrazinamide (X8w)
- Isoniazid + Rifampin (X18 weeks)
Oh how I wish I could get rid of my TB IR
(Ethambutol not involved) |
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|
Term
Isoniazid
- Best activity
- Static effect
|
|
Definition
- Actively multiplying at alveoli
- extracellular neutral PH
isolated efficacy |
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|
Term
Rifampin
- Best activity
- Static effect
|
|
Definition
- Actively multiplying at alveoli
- NONE
Rifampin does it all! |
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|
Term
Pyrazinamide
- Best activity
- Static effect
|
|
Definition
- At acidic PH intracellular
- No activity outside cell
the pirates get really nasty when they enter. outside they are harmless. |
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|
Term
Ethambutol
- Best activity
- Static effect
|
|
Definition
- NONE
- Actively multiplying alveoli & acidic intracellular
Ethan hawk only does outside reconicense missions |
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Term
|
Definition
|
(no Ethambutol, no Pyrazinamide) |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
- Hepatotoxicity (especially slow metabolizers)
- Peripheral neuropathy (treat with B6)
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Term
|
Definition
- Hemolytic anemia
- Methemoglobinemia
- Sulfone syndrome
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Term
|
Definition
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Term
|
Definition
|
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Term
|
Definition
|
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Term
|
Definition
| Inhibit squaline monooxygenase |
|
|
Term
Terbinafine Hydrochloride
MOA |
|
Definition
| Inhibit squaline monooxygenase |
|
|
Term
|
Definition
Blocks synthesis of glucan a polysachuride
cell wall biosynthesis |
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|
Term
|
Definition
- Systemic: Aspergillosis
- Candidiasis: Esophageal
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Term
| Which antifungal may cause endocrynologic abnormalities? |
|
Definition
|
You used your key to open up a can of endocrine side effects |
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Term
|
Definition
- Disrupts cell mitotic spindle
- Deposited n kertain precurser cells
In grease they were spinning their fingers in their hair |
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Term
| Which antifungal may cause nephrotoxicity and anemia? |
|
Definition
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Term
|
Definition
- Ketoconazole
- Miconazole
- KM are small compared to miles
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Term
|
Definition
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