Term
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Definition
1. Isoniazid 2. Rifampin 3. Ethambutol 4. Pyrazinamid |
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Term
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Definition
1. Aminoglycosides 2. Macrolides 3. Floroquinolones 4. Capreomycin 5. Cycloserine 6. Ethionamide 7. para-Aminosacicylic Acid |
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Term
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Definition
4 drugs for 2 months (all first line drugs)= SHORT COURSE TX followed by 2 drugs for 4 months (INH and Rifampin)= CONTINUATION PHASE |
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Term
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Definition
| Inhibits cell wall synth. |
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Term
| Absorption/Administration of INH |
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Definition
-Orally as prodrug -EMPTY STOMACH!!! |
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Term
| Metabolism/Excretion of INH |
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Definition
acetylation -slow acetylators (asians) are at greater risk of hepatotoxicity! (autosomal recessive) -glomerular filtration |
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Term
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Definition
1. Hepatotoxicity (elderly, slow acetylators) 2. Peripheral neuropathy 3.Hypersensitivity |
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Term
Drug interactions/contraindications for INH |
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Definition
inhibits phenytoin decr. dosage in liver/renal pts |
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Term
| What should pts on INH, Ethionamide, or Cycloserine be given to tx/prevent perihperal neuropathy |
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Definition
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Term
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Definition
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Term
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Definition
TB gram + and - H. Flu Menningitis |
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Term
| Is Rifampin Bacteriocidal or Bacteriostatic? |
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Definition
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Term
Administration/Metabolism of Rifampin |
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Definition
oral enterohepatic cycling ->INDUCES P450 enzymes!! |
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Term
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Definition
1. GI 2. Hepatotoxicity (esp when given with INH) |
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Term
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Definition
| in HIV pts w/ TB on a protease inhibitor or NNRTI-> less potent inducer of P450 |
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Term
Interactions/Contraindications of Rifampin |
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Definition
Accelerates metabolism of LOTS OF DRUGS -anticoagulants, antidysrrhythmics, phenytoin, opoids, TCA's, azoles, ect |
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Term
| Rifapentin characteristics |
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Definition
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Term
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Definition
| disrupts plasma membrane and ATP in cell wall |
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Term
| Is pyrazinamide bacteriocidal/static? |
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Definition
-cidal (only actively dividing organisms) |
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Term
| Administration/Metabolism/Excretion of Pyrazinamide |
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Definition
Oral as prodrug hydrolyzed by liver excreted by glomerular filtration |
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Term
|
Definition
1. GI 2. Hepatotoxicity 3. Urate Retention (GOUT!) |
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Term
| What condition should be looked for in a pt who is on pyrazinamide? |
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Definition
Acute Gouty Attack d/t urate retention |
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Term
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Definition
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Term
| is Ethambutol bacteriostatic/cidal |
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Definition
BOTH??? proven active against dividing cells |
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Term
Administration/Metabolism/Excretion of Ethambutol |
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Definition
orally partially metabolized glomerular filtration/tubular secretion |
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Term
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Definition
1.Changes in: visual acuity red/green colorblindedness central vision 2. Urate Retention |
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Term
What tests need to be done on a pt taking Ethambutol? |
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Definition
1. Visual Acuity 2. Baseline LFT's and Urate |
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Term
What should be looked for in a pt taking Ethambutol? |
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Definition
1. Optic/retrotubular neurtitis 2. Acute Gouty Attack |
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Term
Which of the Aminoglycosides should be used first? |
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Definition
| Streptomycin>kanamycin/amikacin |
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Term
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Definition
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Term
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Definition
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Term
| Administration of Capreomycin |
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Definition
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Term
| What drugs is Capreomycin most like? |
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Definition
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Term
AE of Aminoglycosides/Capreomycin? |
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Definition
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Term
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Definition
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Term
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Definition
1. peripheral nephropathy (give B6) 2. CNS |
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Term
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Definition
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Term
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Definition
1. GI** 2. Hepatotoxicity** 3.Peripheral Neuropathy (B6) 4. Optic Neuritis **titrate dosing slowly to reduce AE's |
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