Term
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Definition
| the amount of which is expressed as the strength or dose |
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Term
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Definition
-increase bulk
-organics - starch, lactose, mannitol, microcrystalline cellulose, methyl cellulose
-inorganics - kaolin, bentonite, CaCO3, dicalcium phosphate |
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Term
| binders (adhesives, granulators) |
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Definition
-binding agents helps granules stick together when under pressure and after compression
-ex: Klucel - hyroxypropylcellulose; Natrosol - hydroxyethylcelluose; starch paste, acacia, gelatin, methyl cellulose, glucose, sucrose, ethylcellulose in alcohol |
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Term
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Definition
-causes the tablet to breakup within the body
-hydrophilic substances
-ex: corn starch, bentonite, cellulose derivatives, potato and rice starch |
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Term
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Definition
-reduce friction
- prevents the tablet from sticking to machine or die
- ex: magnesium stearate, Ca stearate, stearic acid
- added after granulation |
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Term
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Definition
improve the flow of the granules during the manufacturing process from hopper into dies
-ex: Cab-O-Sil
- prevents: picking, capping, both produce accurate dosing
- added after granulation |
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Term
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Definition
-absorbs any liquid that may be called for in tablet formulation
- chewable tablets that have volatile oils as flavoring agent
- ex: Mg oxide, Mg carbonate, kaolin, bentonite |
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Term
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Definition
- if not coating- added to binding solution - otherwise can be added to coating solution
-types: soluble, insoluble pigments, "lakes" |
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Term
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Definition
- if intended to be swallowed intact, you do not need flavoring agent
- used - chewable tablets, soluble tablets, lozenges |
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Term
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Definition
| sugar coating, film, enteric coatings can be applied to tablet surface |
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