Term
|
Definition
bulking agent:
makes up for the wight and volume of the tablet |
|
|
Term
|
Definition
dicalcium phosphate
starch
microcrystalline cellulose (MCC)
sugars: lactose,dextrose, sucrose, mannitol |
|
|
Term
|
Definition
must not affest drug stability and absorption
ex: Ca salts should not be formulated with tetracyclines |
|
|
Term
|
Definition
Holds liquids:
water, alcohol, vegetable fluid extracts, etc |
|
|
Term
|
Definition
MCC
Kaolin
Bentonite
Magnesium carbonate |
|
|
Term
|
Definition
| allows granulation and compression of tablets |
|
|
Term
|
Definition
wets drug/excipient mixture
(e.g. for granulation) |
|
|
Term
|
Definition
|
|
Term
binders/adhesives
function |
|
Definition
| holds ingredients together |
|
|
Term
binders/adhesives
chemicals |
|
Definition
solids: MCC, powdered or spray dried acacia
solutions of: gelatin, glucose, sucrose, colloidal clays, various celluloses(methuyl, carboxymethyl, hydroxypropyl), polyvinylpyrrolidone (PVP) |
|
|
Term
|
Definition
blows up the tablet
so that drug can be released in the GI tract
can act by capillary action, swelling, and a variety of mechanism, all involving water |
|
|
Term
|
Definition
starch
ion exchange resins
alginic acid
magnesium aluminum silicate
cellulose |
|
|
Term
|
Definition
commerial super disintegrant include
crosscarmelose (AcDi-Sol)
crospovidone (Kollidon)
sodium starch glycolate (primojel)
|
|
|
Term
Lubricant/Glidant
functions |
|
Definition
| reduces friction during manufacture, ease powder flow |
|
|
Term
Lubricant/Glidant
chemicals |
|
Definition
magnesium stearate (<1%)
talc
stearic acid
PEG
paraffin
Na or Mg lauryl sulfate
starch
colloidal silica |
|
|
Term
|
Definition
for esthetics and product ID
covers up colored drug |
|
|
Term
|
Definition
FD&C blue #1
FD&C red #3
FD&C yellow #6 |
|
|
Term
|
Definition
|
|
Term
flavoring agent/sweetners
function |
|
Definition
|
|
Term
flavoring agent/sweetners
chemical |
|
Definition
mannitol
saccharin
aspartame |
|
|
Term
flavoring agent/sweetners
remarks |
|
Definition
| used in chewable, buccal and SL tabs |
|
|
Term
|
Definition
|
|
Term
|
Definition
sugar coated
film coated (HPMCP, ethylcellulose, povidone, polyethylene glycol)
enteric coating (HPMCP, CAP, PVAP, CAT)
gelatin-coated |
|
|
Term
buffering agents
function |
|
Definition
| maintains less acidic pH around dissolved drug in stomach |
|
|
Term
buffering agent
chemicals |
|
Definition
Na and K citrates
phosphates
hydroxides
carbonates |
|
|
Term
|
Definition
|
|
Term
|
Definition
chelating agent: EDTA, citric acid
antioxifants: ascorboc acid |
|
|
