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Table 7-10
Major Chemical Carcinogens
6
Medical
12th Grade
09/17/2011

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Term
Alkylating Agents
Definition
DIRECT-ACTING CARCINOGENS

β-Propiolactone
Dimethyl sulfate
Diepoxybutane
Anticancer drugs (cyclophosphamide, chlorambucil, nitrosoureas, and others)
Term
Acylating Agents
Definition
DIRECT-ACTING CARCINOGENS

1-Acetyl-imidazole
Dimethylcarbamyl chloride
Term
Polycyclic and Heterocyclic Aromatic Hydrocarbons
Definition
PROCARCINOGENS THAT REQUIRE METABOLIC ACTIVATION

Benz[a]anthracene
Benzo[a]pyrene
Dibenz[a,h]anthracene
3-Methylcholanthrene
7,12-Dimethylbenz[a]anthracene
Term
Aromatic Amines, Amides, Azo Dyes
Definition
PROCARCINOGENS THAT REQUIRE METABOLIC ACTIVATION

2-Naphthylamine (β-naphthylamine)
Benzidine
2-Acetylaminofluorene
Dimethylaminoazobenzene (butter yellow)
Term
Natural Plant and Microbial Products
Definition
PROCARCINOGENS THAT REQUIRE METABOLIC ACTIVATION

Aflatoxin B1
Griseofulvin
Cycasin
Safrole
Betel nuts
Term
Natural Plant and Microbial Products: Others
Definition
PROCARCINOGENS THAT REQUIRE METABOLIC ACTIVATION

Nitrosamine and amides
Vinyl chloride, nickel, chromium
Insecticides, fungicides
Polychlorinated biphenyls
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