Term
| How are phagocytic cells attracted to a pathogen? |
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Definition
| Microorganisms have chemotactic components. |
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Term
| Name a type of T independent cell |
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Definition
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Term
| How do pathogens produce chemotactic components |
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Definition
Alternative pathway:
LPS (endotoxin) activation of complement produces chemotactic molecules which attract phagocytes. |
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Term
| How do phagocytes bind microorganisms |
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Definition
| Via receptors for complement components. The microorganism is then phagocytosed |
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Term
| What type of cells and receptors recognize LPS? |
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Definition
Receptors: Toll-like receptors (TLRs)
on the cells:
PMNs and macrophages |
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Term
| What cells are mannose receptors found on and how do the bind? |
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Definition
| Bind mannose and fructose on microbial glycoproteins and glycolipids. Mannose receptors on MACs and further activate MACs when bound. |
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Term
| Name 3 types of receptors on phagocytic cells such as MACs. |
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Definition
Toll-like receptors (TLRs)
Mannose receptors
Scavenger receptors |
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Term
For acquired immunity, cells recognize detail (specific) structure of antigen (epitope).
For innate immunity cells recognize ? ? |
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Definition
PAMPS, "pathogen-associated molecular patterns", shared by classes of microbes.
example: mannose receptors recognize mannose, which is common on microbial glycolipids.
Or TLR which recognizes complement components (which were activated by LPS endotoxin) |
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Term
| CMI is part of what type of immunity |
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Definition
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Term
| * On the MAC, what type of PAMP does TLR-4 recognize and then signal presence? |
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Definition
It recognizes LPS by binding to CD14.
TLR-4 is called the MAC LPS receptor. |
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Term
| * What does TLR-2 signal presence of |
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Definition
1. Peptidoglycans from Gram + bacteria
2. Lipoproteins
3. Lipoarabinomannan (mycobacteria) |
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Term
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Definition
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Term
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Definition
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Term
| What occurs after phagocytosis? |
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Definition
1. phagosome-lysosome fusion
2. intracellular killing (via degrative enzymes from lysosome) |
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Term
* Which cytokines
up regulate the phagocytic and antimicrobial activities of MACs and PMNs.
And stimulate NK release of interferon gamma. |
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Definition
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Term
The combo of
cytokine stimulation plus receptor recognition of microbial products results in the production of..? |
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Definition
ROIs and nitric oxide.
These plus lysosmal enzymes kill pathogen.
ROIs are reactive oxygen intermediates.
Nitric oxide comes from stimulation of iNOS |
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Term
| What cytokine release stimulates adhesion of phagocytes to the endothelial lining of blood vessels? |
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Definition
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