Term
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Definition
-ligand binds weakly (ionic)
-receptor changes shape
-ligand binds more tightly
-receptor activates |
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Term
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Definition
| -ability of a bound drug to change a receptor in a way that produces an effect |
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Term
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Definition
| drug that occupies and activates a receptor producing a cellular response |
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Term
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Definition
| -drug that occupies a receptor and prevents agonist from binding |
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Term
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Definition
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Term
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Definition
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Term
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Definition
-receptor antagonists
-physiological antagonists
-chemical antagonists |
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Term
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Definition
| -drug binds but does not activate |
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Term
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Definition
-drug binds to a DIFFERENT receptor
-produces an opposite effect |
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Term
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Definition
| -interacts directly with the drug |
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Term
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Definition
-Clark
-effect is proportional to number of receptors occupied |
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Term
| modified occupation theory |
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Definition
-Ariens
-100% occupancy does NOT equal max response
-intrinsic effect determines effect produced by drug (0 to 1) |
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Term
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Definition
-effect is determined by rate dissociation
-high dissociation equals high potency |
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Term
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Definition
-only R* can produce response
-agonists increase R*
-inverse agonists preferably bind to R so decrease R* |
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