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Systems Pharmacology II
CNS anatomy and physiology
26
Biology
Graduate
02/22/2012

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Term
protect the brain
Definition
-skull
-meninges
-CSF
-BBB
Term
dura mater
Definition
-outer layer
-white fibrous CT
Term
arachnoid
Definition
-middle layer
-filled with CSF
-contains blood vessels
Term
pia mater
Definition
-inner layer
-tightly bound to brain and spinal cord
Term
ventricles of brain
Definition
-4
-connected to eachother and to central canal of spinal cord
-lined by ependymal cells
-contain CSF
Term
CSF
Definition
-watery
-less protein/diff ion conc. then plasma
-constant volume
-buoyancy
-protection
-nourishment
Term
choroid plexus
Definition
-produce CSF at a constant rate
-hang from the root of each ventricle
-clusters of capillaries enclosed by pia mater and a layer of ependymal cells (regulate CSF)
Term
hydrocephalus
Definition
-excess CSF in ventricles
-usually caused by a ventricular obstruction
Term
BBB
Definition
-created by tight junctions between endothelial cells
-basement later of blood vessels
-feel of astrocytes
-helps maintain a stable environment for the brain
Term
BBB
Definition
-created by tight junctions between endothelial cells
-basement later of blood vessels
-feel of astrocytes
-helps maintain a stable environment for the brain
Term
get thru the BBB
Definition
-glucose, essential amino acids, electrolytes
-ineffective against lipid soluble substances (alchohol, nicotine,anesthetics)
Term
*BBB absent in
Definition
-*vomiting center (CTZ)
-*hypothalamus
-necessary to monitor chemical composition of the blood
Term
cerebrum
Definition
-83% of total brain mass
-gyri-ridges
-sulci-grooves
-fissures-deep grooves/separate brain regions
Term
transverse cerebral fissure
Definition
-separates cerebellum and cerebrum
Term
central sulcus
Definition
-separates frontal lobe and parietal lobe
Term
lateral sulcus
Definition
outlines temporal lobe
Term
*frontal lobe
Definition
-anterior
-full maturity at age 25
-voluntary movement
-attention
-goal directed behavior
-some speech (Broca's)
-damage-can understand, difficulty speaking,writing, sign language
Term
*parietal lobe
Definition
-sensory integration
-spatial coordination
Term
*temporal lobe
Definition
-speech (Wernicke's)
-memory
-hearing
-some emotional processes
-*damage-can speak "word salad"
Term
*occipital lobe
Definition
-smallest
-visual processing
-damage-hallucinations and illusions
Term
hallucinations
Definition
visual images with no external stimuli
Term
illusion
Definition
distorted perception
Term
cerebral cortex
Definition
-"executive suite"
-conscious mind
-thin gray matter
-billions of neurons
-40% mass of brain
-awareness
-sensory perception
-voluntary motor initiation
-communication
-memory storage
-understand
Term
corpus callosum
Definition
-thick bundle of nerve fibers
-connects 2 hemispheres
Term
Aicardi syndrome
Definition
-rare genetic syndrome
-partial or complete absence of corpus callosom
-seizures,visual disturbances,learning deficits
-X link dominant
-symptoms before 5 months of age
Term
ependymal cells
Definition
-manage waste, ions, and nutrients
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