Term
|
Definition
-UGTs
-OH, NH2, COOH
-cofactor-UDPGA
-liver ER and intestinal epithelia
-glucuronic acid conjugation to phenols, alc, ter. amines, aromatic amines |
|
|
Term
|
Definition
-SULTs
-OH primarily, NH2 lesser
-cofactor-PAPS
-in liver cytosol |
|
|
Term
|
Definition
-NAT
-primary amines
-cofactor-acetyl CoA
-liver
-dec H2O solubility
-variability in population
-products often undergo hydrolysis before elimination |
|
|
Term
|
Definition
-methyltransferases (O, N, S)
-OH, NH2, SH
-cofactor-SAM-e
-dec H2O solubility |
|
|
Term
|
Definition
-2 steps, 2 enzymes
-c. acids
-1st step catalyzed by acyl CoA synthases
-2nd step cat. by N-acyltransferases
-very H2O soluble |
|
|
Term
|
Definition
-GST
-glutathione=gln-cys-gly
-substrates are electrophilic groups
-very important for detoxification of environmental toxicants and carcinogens |
|
|
