Term
| What connects the hypothalamus to the pituitary? |
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Definition
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Term
| Where is ADH and oxytocin synthesized? |
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Definition
| In cell bodies in the supraoptic and paraventricular nuclei of the hypothalamus. |
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Term
| Where are ADH (vasopressin) and oxytocin released? |
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Definition
| Released from the Posterior Pituitary |
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Term
| What are the long portal veins? |
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Definition
| Connect the median eminence of the hypothalamus to the capillaries in the anterior lobe of the pituitary. |
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Term
| How does the hypothalamus regulate the anterior lobe? |
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Definition
| Through synthesis of releasing/inhibiting hormones that are released within the median eminence. |
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Term
| What connects the anterior pituitary to the posterior portion? |
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Definition
|
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Term
| How are hormones in the posterior pituitary released? |
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Definition
| They are released in reaction to action potentials into the systemic circulation. |
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Term
| What hormone controls longitudinal bone growth and metabolism of glucose, amino acids, and fatty acids? |
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Definition
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Term
| What hormone controls the release of GH? |
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Definition
| Growth Hormone Releasing Hormone (GHRH) |
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Term
| _________ blocks the release of GH from the _________ pituitary? |
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Definition
|
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Term
| When is GH secretion maximal? |
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Definition
| With deep (slow-wave) sleep preceded by a large GHRH peak |
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Term
|
Definition
| Liver; t1/2 ~ 6-20 minutes |
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Term
| Effects of GH are observed 12- 18 hours afer GH levels increase due to induction of _______ synthesis in the liver. |
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Definition
| IGF - Insulin-like Growth Factors |
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Term
| T/F: IGF-I and IGF-II do not resemble proinsulin. |
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Definition
| False. They do resemble proinsulin |
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Term
| Which IGF receptor resembles the insulin receptor and is a tyrosine kinase? |
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Definition
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|
Term
| Which IGF receptor is a monomer? |
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Definition
| IGF-II. Binds IGF-I poorly and does not bind insulin. |
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Term
When is the onset of gigantism?
When is the onset of acromegaly? |
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Definition
Childhood or Puberty
After Puberty |
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Term
| What is the impaired function in gigantism? |
|
Definition
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Term
| What are the three levels of impaired function in dwarfism? |
|
Definition
Hypothalamus: No GHRH
Pituitary: No GH
Liver: No IGF-I and IGF-II synthesis |
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