Term
Candida infections can be generally treated with ________ and be eradicated. However, there are resistant species of Candida to ______ such as ____ and ____ |
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Definition
Fluconazole
Fluconazole
C. Krusei
C. glabrata
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Term
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Definition
Binds to ergosterol altering cell membrane permeability in suscptible fungi and causing cell death.
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Term
| How many different formulations of Amphotericin B are there? |
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Definition
Two. The convential Amphotericin B and Lipid formulation.
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Term
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Definition
| Statement. Not a question. |
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Term
| What side effect does Amphoteracin B have on electrolytes? |
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Definition
| decreases potassium and magnesium |
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Term
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Definition
Flucytosine (Ancobon, 5 F-C) penetrates fungal cells and is converted to fluorouracil which competes with uracil, interfering with fungal RNA and protein synthesis. |
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Term
| Flucytosine has many side effects but what's a major caution? |
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Definition
| causes bone marrow suppression. |
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Term
| Should Flucytosine be used as monotherapy? |
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Definition
No. Due to rapid resistance. Should be used as synergy with Amphoteracin B
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Term
| Brand name for Itraconazole? |
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Definition
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Term
| Black box warning for itraconazole |
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Definition
CHF & concurrent administration with cisapride, dofetilide, primozide, and quinidine. |
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Term
| Brand name for Fluconazole? |
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Definition
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Term
| Brand name for ketaconazole |
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Definition
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Term
| Brand name for Voriconazole? |
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Definition
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Term
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Definition
| Take 1 hr before or 1 hr after meals? |
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Term
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Definition
| CI with many 3A4 substrates. |
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Term
| What's a unique side effect of VFEND? |
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Definition
| Visual changes (20% - dose related) |
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Term
| What should be corrected prior to initiating VFEND? |
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Definition
| correct K+, Ca2+, and Mg2+ prior to initating therapy. |
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Term
| What to monitor whilst on VFEND? |
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Definition
| Monitor LFTs, renal function |
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Term
| Because of VFEND's side effect, what counseling to give patients? |
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Definition
| caution driving at night due to vision changes. Avoid direct sunlight. |
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Term
| What is VFEND most active against? |
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Definition
Aspergillus spp.
C. glabrata
C. Krusei
Fusarium spp
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Term
| Brand name for Posaconazole? |
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Definition
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Term
| What counseing information to give patient regarding Posaconazole? |
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Definition
| Must be taken with a full meal. |
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Term
| Can itraconazole be used interchangeably? |
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Definition
NO! Because of differences in bioavailability. Oral capsules and oral solution can not be used interchangeably. |
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Term
What's so special about the capsule formulation of Itraconazole?
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Definition
Capsule form has low bioavailability on an empty stomach -> take with food and requires gastric acidity for adsorption. |
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Term
| A "notable" side effect of Ketoconazole? |
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Definition
Ketoconazole shampoo increases hair loss and altered hair texture. |
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Term
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Definition
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Term
| Itraconazole is major inhibitor of? |
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Definition
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Term
| Ketoconazole is a strong inhibitor of? |
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Definition
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Term
| Fluconazole is strong inhibitor of? |
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Definition
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Term
| Posaconazole is a strong inhibitor of? |
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Definition
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Term
| Which azoles haev ph-dependent absorption? |
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Definition
| Itraconazole and ketoconazole |
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Term
| Which of the azoles is notable for its drug interactions? |
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Definition
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Term
| Voriconzaole has what type of metabolism. |
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Definition
| 1st order followed by michaelis - menten kinetics. |
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Term
| Voriconazole's use is contraindicated with of the following medicaitons? |
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Definition
A shit load. Just don't recommend it unless the fungus is resistant to fluconazole. |
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Term
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Definition
Inhibit synthesis of beta (1-3) - D - glucan, an essential component of the fungal cell wall. |
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Term
| Brand name for Caspofungin? |
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Definition
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Term
| Brand name for Micafungin? |
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Definition
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Term
| Brand name for Anidulafungin? |
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Definition
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Term
| Dosing of Micafungin for Candidemia? |
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Definition
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Term
| Dosing of Micafungin for Esophageal Candidiasis? |
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Definition
| 150 mg IV qd over 60 minutes. |
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Term
| DOC for treating Aspergillus spp? |
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Definition
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Term
| DOC for oral candidiasis? |
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Definition
Non - AIDS: Clotrimazole
AIDS: Fluconazole
Treatment duration 7 - 14 days.
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Term
| DOC and treatment duration for Esophageal candidiasis? |
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Definition
| Fluconazole, 14 - 21 days |
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