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Synaptic Transmission
Dr. Colden-Stanfield
19
Physiology
Professional
08/12/2008

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Cards

Term
Characteristics of Electrical Synapse
Definition

Gap Junctions

  • Adjacent cells
  • Cytoplasmic continuity
  • Small molecules and ions
  • Bidirectional flow of signal
Term
Characteristics of Chemical Synapse
Definition
  • Most predominant
  • Not structurally connected
  • Transmitter released through exocitosis
  • Unidirectional flow
  • Need mitochondrial energy for the enzymes that synthesize the transmitters.
Term
Axosomatic Synapses
Definition

Synapse is at the soma(cell body) of the next neuron.

Stronger signal because it has to go a shorter distance to reach trigger zone.

Term
Axodendritic Synapses
Definition

Synapse is at a dendrite of the next neuron.

Proximity to trigger site determines how strong the signal will be when it reaches there.

Term
Axo-axonic Synapse
Definition

Synapse is at the axon terminus of the next neuron.

 

Controls the release of transmitters by the next neuron.

Term
Whats the only exampl of a one-to-one Synapse?
Definition
Neuromuscular Junction
Term
Features of Chemical Synaptic Transmission (Step by Step)
Definition
  • Presynaptic Action Potential→
  • Depolarization causes more permeability to Ca++ ions→
  • Release of transmitter through exocitosis→
  • Transmitter reacts with post-synaptic receptor→
  • Channels open, Postsynaptic potential→
  • Action Potential
Term

Quanta

Definition

Packets that the transmitters are traveling in

Term
Quantum
Definition

How many transmitters are in each Quanta

Term
Unit Synaptic Potential
Definition

The amount of potential that each Quanta produces.

Term

Excitatory Postsynaptic Potentials (EPSPs)

Definition

Postsynaptic potentials that depolarize the membrane tend to excite the nerve cells to discharge action potentials.

  • opening Na channels
  • closing K or Cl
Term

Temporal Summation

Definition

Consecutive synaptic potentials arrive at the postsynaptic cell and add together.

Term
Spacial Summation
Definition

Two seperate inputs arrive simultaneously at the postsynaptic cell and add together.

Term
Presynaptic Facilitation
Definition

Excititory

Enhances the release of transmitters

 

Presynaptic inhibition would do the opposite

Term

Facilitation or potentiation-

Definition

No time to bring Ca++ levels down. 

Describes a progressive increase in the amount of

transmitter release by successive action potentials during a brief stimulus train lasting up to a few seconds.

Facilitation dies away rapidly, within tens to hundreds of milliseconds after the end of stimulation.

Term

Posttetanic potentiation

Definition

Large Membrane

describes an increase in transmitter release by an actionpotential following repetitive stimulation of a synapse. Posttetanic potentiation requires seconds to develop and lasts tens of seconds to several minutes after cessation of tetanic stimulation. PTP occurs at the neuromuscular junction. PTP might well be a mechanism of “short-term” memory in the CNS.

Term

Synaptic fatigue

Definition
Depleting transmitter stores. Like a seizure
Term
What is the mechanism and signal properties Electrical PSP?
Definition

Mechanism: ΔVoltage, ΔpH, ΔCa++

 

Signal properties: Graded, Fast

Term
Receptor Potential (type and mechanism of ion channel..signal properties)
Definition

Type: single class channels for Na+ and Ka+

 

Mechanism: Sensory stimulus

 

Signal Properties: Graded, Fast

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