Term
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Definition
| inhibitors of folic acid synthesis |
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Term
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Definition
| selective inhibitor of dihydrofolate reductase |
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Term
| trimethoprim plus sulfamethoxazole for |
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Definition
| sequential blockade of folate synthesis |
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Term
| clinical use of sulfonamides |
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Definition
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Term
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Definition
| H. influenzae and M. catarrhalis and PCP |
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Term
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Definition
| interfere w/ DNA synthesis by inhibiting topoisomerase II |
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Term
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Definition
| E coli, K. pneumoniae, C. jejuni, enterobacter, P aeruginosa, salmonella, shigella, UTIs and GI infections |
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Term
| which statement about sulfonamides is accurate |
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Definition
| dysfunction of the basal ganglia may occur in the newborn if sulfonamides are administered late in pregnancy |
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Term
| combination of TMP-SMX is effective against which opportunisitic infection in the AIDS pt |
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Definition
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Term
| a 24 yo F has returned from a vacation abroad suffering from traveler's diarrhea, and her problem has not responded to antidiarrheal drugs. a pathogenic gram-negative bacillus is suspected. which drug is most likely to be effective in the tx of this pt |
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Definition
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Term
| which statement about the clinical use of sulfonamides is false? |
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Definition
| sulfonamides are effective in rocky mountain spotted fever in pts allergic to tetracyclines |
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Term
| a 31 yo man has gonorrhea. he has no drug allergies, but a few years ago acute hemolysis followed use of an antimalarial drug. the physician is concerned that the pt has an accompanying utrethritis caused by C. trachomatis, although no cultures or enzyme tests have been performed. which of the following drugs is most likely to be effective against both gonococci and c. trachomatis in this pt |
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Definition
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Term
| which statement about the fluoroquinolones is accurate |
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Definition
| gonococcal resistance to fluoroquinolones may involve changes in DNA gyrase |
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Term
| a 55 yo man complains of periodic bouts of diarrhea w/ lower abdominal cramping and intermittent rectal bleeding. seen in the clinic, he appears well nourished, w/ blood pressure in the normal range. examination reveals moderate abdominal pain and tenderness. his current medications are limited to loperamide for his diarrhea. sigmoidoscopy reveals mucosal edema, friability and some pus. laboratory findings include mild anemia and decreased serum albumin. microbiologic examination via stool cultures and muscosal biopsies do not reveal any evidence for bacterial, amebic or CMV involvement. a preliminary diagnosis is made of mild to moderate ulcerative colitis. the most appropriate drug to use is |
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Definition
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Term
| which statement about the combination of TMP-SMX is false |
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Definition
| it is appropriate for the tx of community-acquired pneumonia |
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Term
| which adverse effect is most likely to occur w/ sulfonamides |
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Definition
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Term
| which drug is effective in the tx of nocardiosis and in combination w/ pyrimethamine, is prophylactic against PCP infections in AIDS pts |
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Definition
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Term
| which statement about ciprofloxacin is accurate |
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Definition
| tendinitis and tendon rupture may occur during treatment |
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Term
| supplementary folinic acid may prevent anemia in folate deficient persons who use this drug, a weak base that achieves tissue levels similar to those in plasma |
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Definition
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Term
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Definition
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