• Broad Spectrum
• Bacteristatic
• Inhibits dihydropteroate synthase which inhibits first step of folic acid synthesis
• Pregnancy Category B

• Dihydrofolate reductase inhibitor

• inhibits bacterial DHFR
• Side Effects: blood dyscrasias

Pyrimethamine

• inhibits protozoal DHFR
• Antimalarial

Methotrexate

• Inhibits mammalian, bacterial, andprotozoal DHFR

• New for T celllymphoma

• With erythromycin (a macrolide) as prophylasxis vs recurrent otitis media.
• Oral

• with trimethoprim (Bactrim, Septra)
• aka Co-Trimoxazole; TMP-SMZ
• Oral

• Bleph-10 (refers to eyelid)
• Ulcerative blepharitis usually caused by S. aureus, S. epidermidis
• Bacterial conjunctivitis caused usually by S. aureus, Strep pneumoniae, H. influenzae, Moraxella catarrhalis most common causes
• Topical

• Used for burns to prevent sepsis
• Silver is toxic to microorganisms
• Sulfa can be absorbed and systemmic-->bad side effects
• Topical

• For Burns
• Limited use
• Can cause acidosis by inhibiting carbonic anhydrase--> loss of HCO3- and lose buffering capacity
• Topical

• Crystalluria
• Kernicterus
• Blood Dyscrasias
• Hypersensitivity