Term
DNA/nucleic acid synthesis inhibitors
1. Name the family
2. MOA |
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Definition
1. Sulfonamides
2. compete with PABA for active site on Dihydropreroate Synthase (DHTS) |
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Term
| Name the short acting sulfinamides |
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Definition
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Term
| Name the intermediate acting sulfonamides |
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Definition
Sulfadiazine
Sulfamethaxazole |
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Term
| Name the long acting sulfonamides |
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Definition
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Term
| What is used to treat burns |
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Definition
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Term
| WHat is used to treat Ulcerative colitis? |
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Definition
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Term
| How is resistance acquired to sulfonamides? |
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Definition
1. Increased PABA production (as sulfonamides act as competative antagonists)
2. Decreased drug uptake
3. Altered DHTS enzyme |
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Term
| What is the DOC for P. carinii? (aids pt) |
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Definition
Cotrimoxazole
(trimethoprime 1: 5 sulfamethoxazole) |
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Term
| What is the MOA of trimethoprime, methotrexate & pyrimethamine? |
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Definition
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Term
| how are sulfonamides used to treat malaria? |
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Definition
| Sulfadoxine + pyrimethamine |
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Term
| What are the ADR's of sulfonamides? |
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Definition
Phototoxicity
Hypersensitivity rxn - rashes - stevens-johnson syndrom
Crystalluria - nephrotoxic
Hemolysis in G-6PD deficiency
Kernicterus - if mother takes in 3rd trimester of preg
Displaces portein bount drugs - warfarin, methotrexate, phenytoin etc |
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Term
| what is specifically special to trimethoprime? |
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Definition
| used to treat vaginitis or prostatitus as it has high concentratins in those areas |
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Term
| how is the crystalluria/nephrotoxicity counteracted in sulfonamides? |
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Definition
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Term
| What is used in the treatment of RA & ulcerative colitis & why |
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Definition
| Sulfasalazine - reduces production of PG & LT's |
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Term
| What is used to treat toxoplasma gondii? |
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Definition
| sulfadiazine + pyrimethamine |
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