Succinylcholine

(Anectine)

Classification:

Depolarizing neuromuscular blocking agent 

Paralytic

Actions:

Binds with cholinergic receptor sites and causes

depolarization of skeletal muscle cells followed by paralysis

by blockage of acetylcholine

Indications:            

 Rapid sequence intubation (RSI)

Contraindications: 

Malignant hyperthermia

Hypersensitivity

Penetrating eye injuries

Risk of hyperkalemia (burns, crush injury)

Adverse Effects:

Cardiovascular

bradycardia            

hypotension                     

dysrhythmias

Respiratory

depression

bronchospasm

 apnea

Gastrointestinal                                                                                 

nausea / vomiting

Administration:      

     1-1.5mg/kg, IV/IO/IM

Pediatrics:                

         1-2 mg/kg, IV/IO/IM

Onset:                        

Duration:                  

Onset:    IV  – 1 minute  IM – 2-3 minutes

Duration:  IV  – 2-3 minutes     IM – 10-30 minutes