• Anxiety
• Hyperreflexia
• HTN
• Tachycardia
• Sweating
• Hyperthermia
• N/V

(Alcohol)

Stage 1 OH withdrawal

(6-8H)

• Auditory & Visual halucinations
• Anxiety
• Tremor

(Alcohol)

Stage 2 Alcohol withdrawal

(24H)

• Seizures

 (Alcohol)

Stage 3 Alcohol withdrawal

(7-48H)

• Delirium Tremens
• Tachycardia
• Fever

(Alcohol)

Stage 4 Alcohol withdrawal

(3-5D)

• Blood shot eyes
• Decreased BP
• Memory impairment
• Drowsiness

• Tremor/muscle twitching
• NV
• Anxiety/Restlessness
• Yawning
• Tachycardia, ↑ BP
• Seizure/Convulsions

• Apathy
• Psychomotor retardation
• Sedation
• Attention impairment
• Miosis

• Bone/joint/muscle pain
• Anxiety/Imsomnia
• Tachycardia
• Lacrimation
• Hypertension
• Yawning
• Piloerection

• Psychomotor agitation
• Hypervigilance
• Sweating/Chills

• Fatigue
• Sleep disturbance
• Depression
• Paranoid Psychosis

• Sense of well being
• Relaxation
• Slowing of thought process

CYP 3A4 inhibitor

(Increase methadone)

• Amiodarone
• Clarithromycin
• Grapefruit juice
• Ketoconazole

(Angry Clowns Gleefully Juggle Kids)

CYP3A4 Inducers

(Decrease Methadone)

• Carbamazepine
• Efavirenze
• Phenytoin
• Rifampin

(Cute Elves Plan Raves)

Short acting benzos

• Alprazolam
• Estazolam
• Lorazepam
• Oxazepam
• Temazepam
• TriaAzolam

(Adults Eat Lots Of Tater Tots)

• Chlordiazepoxide
• Clonazepam
• Diazepam
• Flurazepam

(Cool Canadians Drive Fast)

• Abuse

• Overwhelming involvement with the use of a drug or its supply
• Strong tendency to relapse after discontinuation

• Benzodiazepines
• Thiamine

• Disulfiran
• Naltrexone
• Acamprosate

Naltrexone

Disulfiran

• Methadone
• Bupranorphine

• Buprenorphine
• Naltrexone