Term
| In the spleen, is the red pulp on the inside or outside? |
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Definition
Red pulp = outside
White pulp = inside |
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Term
| What tissue origin are lymphocytes from? |
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Definition
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Term
| Are there any afferent vessels to the thymus? |
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Definition
no
Tight blood-thymus barrier exists |
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Term
| What HLA is associated with hemochromatosis? |
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Definition
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Term
| What HLA is assoc w/ grave's disease? |
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Definition
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Term
| What HLA is assoc w/ multiple sclerosis, hay fever, SLE and Goodpastures? |
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Definition
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Term
| What HLA is assoc w/ T1DM? |
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Definition
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Term
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Definition
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Term
| What HLA is assoc w/ B12 def (pernicious anemia) and Hashimoto's? |
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Definition
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Term
| What HLA is assoc w/ steroid-responsive nephrotic syndrome? |
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Definition
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Term
| What do Th1 cells secrete? What do they do? |
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Definition
IL-2 = activates helper and cytotoxic T cells
IFN-gamma = activates macros |
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Term
| What 2 Ig's activate complement? |
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Definition
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Term
| Deficiency of what complement component leads to hereditary angioedema? |
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Definition
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Term
| What disease is caused by the deficiency of DAF (GPI-linked enzymes)? |
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Definition
| Paroxysmal Nocturnal Hemoglobinuria |
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Term
| What is the mnemonic for what the IL's do? |
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Definition
Hot T-Bone stEAk
IL-1 = fever, IL-2 = stims T cells, IL-3 = stims Bone marrow, IL-4 = stims IgE prod, IL-5 = stims IgA prod |
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Term
| What cell surface proteins are present on NK cells? |
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Definition
| receptors for MHC I, CD16, CD56 |
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Term
| What cell surface proteins are located on macrophages? |
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Definition
| MHC II, B7, CD40, CD14 (bound by endotox/LPS), rec for Fc and C3b |
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Term
| T1DM, multiple sclerosis and Guillain-Barre are what type of hypersenstivity? |
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Definition
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Term
| XR. Recurrent bacterial infections after 6 mos due to opsonization defects. Decrease in immunoglobulins of all classes, only pro-B |
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Definition
Brutons agammaglobulinemia
Defect in BTK (tyr kinase) blocks pro-B from forming Pre-B |
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Term
| Increased IgM and decreased everything else. Pyogenic infections |
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Definition
Hyper-IgM syndrome
Defective CD40L on Th cells (can't class switch) |
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Term
| IgA def. Sinus and lung infections, milk allergies and diarrhea. |
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Definition
Selective Ig def
Defect in isotype switching. Usually w/ IgA |
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Term
| Decreased plasma cells, nl B cells, decreased Ig |
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Definition
Common Variable Immunodef
Defect in B cell maturation |
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Term
| Tetany, recurrent viral/fungal infxns, congenital heart and great vessel defects |
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Definition
DiGeorge Sx
Thymus and parathyroids fail to dev |
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Term
| Disseminated mycobac infections, decreased Th1 response, decreased IFN-gamma |
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Definition
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Term
| Coarse Facies, staph Abscesses, retained Teeth, increased IgE, Dermatologic probs |
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Definition
Hyper-IgE (Job's) syndrome
Th cells fail to produce IFN-gamma |
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Term
| Def in B and T cells. SCID |
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Definition
| Def IL-2 rec (X-linked), adenosine deaminase def (adenine is toxic to B and T cells), failure to synthesize MHC II antigens |
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Term
| Cerebellar defects, spider angiomas, IgA def |
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Definition
Ataxia-telangiectasia
Defect in DNA repair enz
IgA def |
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Term
| Triad of thrombocytopenic purpura, Infections and Eczema, decreased IgM and increased IgE/IgA |
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Definition
Wiskott-Alrich
XR
Progressive deletion of B and T cells |
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Term
| Recurrent bac infections, absent pus formation, delayed separation of the umbilicus |
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Definition
Leukocyte adhesion deficiency
Defect in IFA-1 integrin on phagocytes
Neutrophilia |
|
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Term
| Recurrent pyogenic infections by staph and strep, partial albinism and peripheral neuropathy |
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Definition
Chediak-Higashi
AR
defect in microtubular function |
|
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Term
| Susceptibility to catalase+ orgs (S. aureus, E. coli, aspergillus) |
|
Definition
Chronic granulomatous dx
Lack of NADPH oxidase
Negative nitroblue tetrazolium dye reduction test |
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Term
| What does azathioprine do? |
|
Definition
| Precursor of 6-mercaptopurine |
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Term
| What is Filgrastim and Sargramostim? |
|
Definition
Filgrastim = G-CSF (granulocyte)
Sargramostim = GM-CSF (granulocyte macrophage) |
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Term
| What is alpha-interferon used in? |
|
Definition
| Hep B and C, Kaposi's, leukemias, malignant melanoma |
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|
Term
| What is beta-inferon used for? |
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Definition
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