Term
| gram stain and shape of Streptococcus? |
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Definition
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Term
| what does capnophilic mean? |
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Definition
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Term
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Definition
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|
Term
| what is the major antigen associated with GAS? |
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Definition
| M protein. if it isnt present, then its not pathogenic. |
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Term
| Rule of thumb: "If it has a capsule, then..." |
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Definition
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Term
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Definition
| presented on surface and aids in opsonization of the microbe by macrophages |
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Term
| is C3b deposited on surface? |
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Definition
| yes, but its masked by its hyaluronic acid capsule |
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Term
| what do adhesins bind to (and for what purpose), and how do they affect the host cell's signaling pathways? |
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Definition
| fibronectins, eventually allowing them inside the cells to hide from immune system and ABx. mess up signaling pathways. |
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Term
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Definition
| streptococcal pyrogenic toxin (2 docs injected themselves with 3-5 micrograms and died). |
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Term
| what are the characteristics of the cytolytic toxin, Streptolysin S? |
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Definition
| oxygen stable (the "S" stands for "stable"), non-immunogenic |
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Term
| what are the characteristics of the cytolytic toxin, Streptolysin O? |
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Definition
| Oxygen labile, immunogenic |
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Term
| Are anti-streptolysin O (ASO) antibodies useful in documenting GAS infections? |
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Definition
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Term
| Do you get these antibodies in skin infections? |
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Definition
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Term
| when you have a GAS infection, where can you find DNAase B antibodies? |
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Definition
| they are in all infections. (ASO antibodies are not in skin infxns) |
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Term
| what does streptokinase do? |
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Definition
| breaks up clots (used by the bug and in clinic) |
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Term
| can S. pyogenes mess with the complement pathway? |
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Definition
| yes, it has C5a peptidase. |
|
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Term
| what do lysogenic phages do the virulence of S. pyogenes? |
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Definition
| increase it by introducing new "weapons" |
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Term
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Definition
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Term
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Definition
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Term
| T/F: GAS is a major cause of pharyngitis |
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Definition
| True. (if a person comes with a sore throat, you HAVE to test for strep! otherwise its an automatic malpractice) |
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Term
| what is a complication of pharyngitis? |
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Definition
| Scarlet Fever (without ABx, can kill) |
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Term
| what is the difference between Streptococcal Toxic Shock Syndrome (TSS)and TSST-1 (from staph)? |
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Definition
| TSS has bacteremia and extensive soft tissue infection, afflicts older men&women |
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Term
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Definition
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Term
| what happens as you go from Erysipelas to pyoderma to cellulitis to necrotizing fascitis? |
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Definition
| works from superficial to deep infections. |
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Term
| can you use ABx on necrotizing fascitis? |
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Definition
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|
Term
| once more, do you get ASO antibodies in skin infxns? |
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Definition
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|
Term
| Can Rheumatic Fever and Acute Glomerulonephritis be caused by GAS? |
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Definition
| Yes (look for PBL case on acute glomerulonephritis) |
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|
Term
| what is the metabolism characteristic of GAS; anaerobe, obligate anaerobe, etc...? |
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Definition
| anaerobic (NOT obligate anaerobe so it can grow in presence of oxygen) |
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|
Term
| what do you use for treatment? |
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Definition
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|
Term
| what is the hemolysis pattern of Group A Streptococcus? |
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Definition
|
|
Term
| what is the hemolysis pattern of Group B Streptococcus? |
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Definition
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Term
| what is the Genus and species of Group B Strep (GBS)? |
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Definition
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Term
| in which human population do you find the most problems with GBS? |
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Definition
| newborns (early & late onset neonatal diseases) |
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Term
| what do capsules protect against? |
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Definition
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|
Term
| streptococcus pneumoniae (activates/deactivates) the alternative complement pathway. |
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Definition
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