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Step 1 - Pharm - Pharmacodynamics
First Aid 2012 258-261
8
Pharmacology
Professional
05/23/2012

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Term
Clearance is equal to
Definition
rate of elimination/plasma drug concentration

OR

Vd*Ke
Term
Half life =
Definition
half life = .7*Vd/Cl
Term
Calculating loading dose
Calculating maintenance dose
Definition
Loading dose = Desired plasma concentration*Vd/F
Maintenance: Desired plasma concentration*Cl/F
Term
How must you adjust the loading and maintenance doses in liver or renal disease?
Definition
Loading dose unchanged
maintenance dose decreased
Term
Drugs with zero order kinetics
Definition
PEA
Phenytoin
Ethanol
Aspirin
Term
Examples of phase 1 and phase 2 metabolism
Definition
Phase 1 = p-450
Phase 2 = GAS (glucoronidation, acetylation, sulfation)
Term
What happens to drug metabolism as we age?
Definition
Phase 1 decreases
Phase 2 stays constant
Term
Therapeutic index
Definition
LD50/ED50
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