Bug:

S. aureus

Tx:

Vancomycin (Inpatient)

Bactrim (Outpatient)

Linezolid

Daptomycin

Tigecycline

Clindamycin

Bug:

Group A Strep (pyogenes) beta-hemolytic

Tx:

Beta-lactams

Cephalosporins except Ceftazidime

Tetracyclines

Macrolides

Bug:

S. aureus (Bullous)

Group A strep (pyogenes)

Tx:

Bullous MRSA (Vancomycin)

Cephalexin, Dicloxacillin

Erythromycin, Clindamycin (PCN Allergy)

Mupirocin

Bug:

Group A Strep

Tx:

PenG IV

PENV po

Erythromycin, Clindamycin (PCN allergy)

Vancomycin (w/ no improvement)

Bug:

S. aureus, G+cocci, Gram- bacilli

Empiric Tx:

Aspiration

CA-MRSA: Bactrim (pus), beta-lactam (no pus)

Necrotizing fasciitis

Type I

Type II

Type I: Anaerobes (Bacteroides/Clostridium), staph aureus, strep, enterbacter

Type II: S. pyogenes (systemic toxicity)

Tx:

Surgical debridement

Strep: PCN (add clindamycin)

Clostridia: PCN (add clindamycin)

Alt. ceftriaxone or erythromycin

Polymicrobial: Carbapenem +/- vanco or dapto

Diabetic foot infection/Pressure sores

Bugs: S. aureus, streptococci, enterobacteriaceae, bacteroides, pseudomonas aeruginosa

(gram -/+, MRSA, nosocomial bugs)

Tx:

Vancomycin + Pipercillin/tazobactam

Aminoglycosides

Tigecycline + Ceftazidime

Metronidazole

Bugs: Pasteurella multocida, S. aureus, Streptococci, Bacteroides sp.

Tx:

Amox/Clav or FQ + Clindamycin

Bug: Eikenella (gram -), S. aureus, Strept, Bacteroids

Tx:

Early: Augmentin

Infected: Ampillic/Sub or Cefoxitin or Zosyn or

Clindamycin + (FQ or SMX-TMP)

MIC = 2 associated with tx failures

potential for renal toxicity

kills slower than beta-lactams (inferior for tx of MSSA)

blocks toxin production

gram (-) anaerobes

gram positive coverage

cannot be used for pneumonia --> destroyed by pulmonary surfactant

CPK increases -->hold statins