Term
|
Definition
MoA:
- affects lipid, nucleic acid, glycolysis; inhibition of mycolic acid biosynthesis;
Indications:
- primary drug for tuberculosis;
- never used alone, resistance develops;
Toxicities:
- peripheral neuropathy;
- hepatitis, elevated LFTs;
FIRST LINE antituberculosis agent used with Rifampin |
|
|
Term
| rifampin (Rifadin, Rimactane) |
|
Definition
MoA:
- suppresses RNA synthesis, specifically bacterial DNA-dependent RNA polymerase;
- forms stable drug enzyme complex;
Indications:
- primary drug for tuberculosis;
- never used alone, resistance develops;
- LEPROSY;
Toxicities:
- GI disturbances (most common);
- reduces blood levels of many drugs;
- red color: all excretions;
FIRST LINE antituberculosis agent;
Treatment for Leprosy; |
|
|
Term
|
Definition
MoA:
- possibly inhibits incorporation of mycolic acid to mycobacterial cell wall;
Indications:
- only against Mycobacteria;
- primary drug for Tuberculosis;
- never use alone, resistance develops;
Toxicity:
- optic neuritis (reversible);
- rash;
FIRST LINE antituberculosis agent used with isoniazid; |
|
|
Term
|
Definition
MoA:
- converted to POA by mycobacteria, POA lowers pH, preventing growth;
Indications:
- specific for Mycobacterium tuberculosis;
- never use alone, resistance develops;
Toxicity:
- hepatotoxicity (most frequent);
- hyperuricemia (gout possible);
FIRST LINE antituberculosis agent used with isoniazid; |
|
|
Term
|
Definition
MoA:
- binds to DNA inhibiting mycobacteria growth;
Indications:
- treatment of Lepromatous Leprosy;
Toxicities:
- GI: pain, N/V, intolerance;
- Skin discoloration: pink to brownish/black;
M. avium; Leprosy; |
|
|
Term
|
Definition
MoA:
- probably like sulfonamides, inhibition of folic acid synthesis;
Indications:
- active against Mycobacterium leprae, never used alone, resistance develops;
Toxicities:
- hemolytic anemia;
- methemoglibinemia;
- sulfone syndrome;
Treats ALL forms of Leprosy; |
|
|
