Term
| long, thin, flexible, highly motile w/ spirals |
|
Definition
|
|
Term
| periplasmic flagella that wrap around cell body ending near the middle |
|
Definition
|
|
Term
| definitive diagnosis of t. pallidum |
|
Definition
| positive darkfield microscopy + characteristic skin lesions |
|
|
Term
| obligate parasites of humans |
|
Definition
| spirochetes, though some can be normal flora |
|
|
Term
| treponema pallidum subspecies pallidum causes |
|
Definition
|
|
Term
| treponema pallidum subspecies endemicum |
|
Definition
|
|
Term
| common STD in white male-seeking-male populations |
|
Definition
|
|
Term
|
Definition
| primary, secondary, latent, tertiary |
|
|
Term
|
Definition
| local infection; chancre (round painless lesion often ulcerated); contains lots of T. pallidum |
|
|
Term
|
Definition
| Disseminated infection; about 6 weeks after infection; meningovascular syphilis; "nickel and dime" lesions |
|
|
Term
|
Definition
| asymptomatic, persist for life, spontaneously cured |
|
|
Term
| Tertiary syphilis has 3 severe sequelae |
|
Definition
| gummatous, neurosyphilis, cardiovascular syphilis |
|
|
Term
|
Definition
| tertiary; granulomatous lesions of accumulations of lymphocytes; marked tissue destruction |
|
|
Term
|
Definition
| tertiary; paresis, tabes dorsalis |
|
|
Term
|
Definition
| tertiary; can cause aortic aneurisms |
|
|
Term
| newborn: skin and mucous membrane lesions, lung liver and bone problems |
|
Definition
| early congenital syphilis |
|
|
Term
| teenager: notched teeth, wrinkled skin, clouding of cornea |
|
Definition
|
|
Term
|
Definition
| detect antibodies against cardiolipin; screening test for syphilis; RPR test |
|
|
Term
|
Definition
| detect antibodies against T. pallidum; used as a confirmatory test |
|
|
Term
| Jarish-Herxheimer reaction |
|
Definition
| associated with T. pallidum |
|
|
Term
|
Definition
|
|
Term
| nonvenereal disease, rare, syphilis |
|
Definition
| Endemic syphilis (endemicum) |
|
|
Term
| nonvenereal, tropical areas, nondestructive skin lesions and bone deformities |
|
Definition
| Yaws (T. pallidum pertenue) |
|
|
Term
| chronic nonpigmented skin lesions in Latin america; form of syphilis |
|
Definition
|
|
Term
| Cause: periodontal disease |
|
Definition
| normal flora: anaerobes + oral spirochetes |
|
|
Term
| Louseborne relapsing fever; bacteremia |
|
Definition
|
|
Term
| spirochete found in blood that is visible with aniline dyes |
|
Definition
|
|
Term
| tickborne relapsing fever |
|
Definition
|
|
Term
| rigors, high fever, gets better after a few days then relapses |
|
Definition
|
|
Term
|
Definition
| genes that alter antigenic variant to cause relapse |
|
|
Term
|
Definition
| Single VMP gene that is expressed |
|
|
Term
|
Definition
| library of 30 unexpressed VMP genes that can be moved to EP |
|
|
Term
|
Definition
|
|
Term
| reservoir for B. burgdorferi |
|
Definition
|
|
Term
|
Definition
stage 1: erythema migrans (red rash w/ expanding margins
stage 2: disseminated infection, Bell's palsy, cardiac arrhythmias, fatigue
Stage 3: persistent, arthritis, neurologic and raised skin lesions |
|
|
Term
| reservoir for B. burgdorferi |
|
Definition
|
|
Term
| diagnostic measures for B. burgdorferi |
|
Definition
| mostly clinical but can get a two-tiered test (ELISA + western blot) |
|
|
Term
| Lyme disease but in the South |
|
Definition
| Southern Tick-Associated Rash Illness (STARI) may be due to B. lonestari |
|
|
Term
| spirochete; animal reservoir; long-term secretion in urine |
|
Definition
|
|
Term
| transferred via urine of infected rats and dogs; can survive in water for long time |
|
Definition
|
|
Term
| about a week after contact; severe myalgias of leg and back, conjunctival suffusion, skin rash |
|
Definition
|
|
Term
| Weils syndrome: severe illness |
|
Definition
|
|
Term
| 2ndary phase: recurrence of fever, but organism is gone from blood and CSF |
|
Definition
| Leptospira, can still be found in urine and aqueous humor |
|
|
Term
|
Definition
| serum antibodies agglutinate leptospira |
|
|
