Term
| Characteristics of good antigens |
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Definition
*Stimulate the formation of CMI or AMI
*Molecular weight more than 10,000
*Complex in structure to promote strong immune response
*Proteins, polysaccharides, nucleoproteins, lipoproteins, glycoproteins |
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Term
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Definition
Secondary immune response
Forms after initial encounter with antigen (primary response) |
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Term
| End product of complement activation |
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Definition
*Induction of inflammatory response
*Opsonization of cells
*Lysis of certain bacteria or viruses |
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Term
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Definition
*Antibodies found in blood (plasma) & lymph & extravascular tissues & body fluids *B cells work here
*Named humoral immunity indicating presence in body humors (fluids) |
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Term
| Outcomes of antibody-antigen reactions |
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Definition
Activation of Complement:
*Inflammatory response
*Opsonization
*Lysis of certain bacteria or viruses |
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Term
| Where B cells & T cells mature |
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Definition
*T cells - thymus
*B cells - bone marrow (adult red bone marrow) |
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Term
| Differences between Innate & Adaptive immunity |
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Definition
Innate=immediate
Adaptive=develop over time
*antigen-specific
*reacts only with organism that induced response
*forms memory for each immune response |
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Term
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Definition
°Bone marrow
*hemapoeisis
*produces Granulocytes & Agranulocytes, RBC & platelets
°Thymus
*lymphs produced in marrow migrate to mature into T lymphs
°Spleen
*made up of B cells, T cells, macrophages, dendritic cells, NK cells & rbcs
*present T & B cells
°Lymph nodes
*present T & B cells |
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Term
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Definition
| B & T cells that interact with self antigens are destroyed during fetal development |
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Term
| Two major classes of Adaptive acquired immunity |
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Definition
°AMI=antibody-mediated immunity (humoral immunity)
*infectious agents in the blood and body tissues
°CMI=cell-mediated immunity
*body cells that have been infected |
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Term
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Definition
B - 100,000 membrane-bound IgG or IgM acting as receptors
T - 1000s antigen-binding T cell receptors
*subset CD4 or CD8 |
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Term
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Definition
| substance that reacts with products of specific immune response |
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Term
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Definition
*protein produced by B cells secreted into blood
*disulfide bonds
*stem of Y is Fc region/polypeptide
*arms of Y is Fab region/antigen binding region |
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Term
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Definition
| # of antigen binding sites on antibody molecule |
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Term
| Valence per antibody classes |
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Definition
IgM=10
IgA=4
IgD=2
IgG=2
IgE=2 |
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Term
| Where antibodies found in serum fractions |
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Definition
*alpha globulin
*beta globulin
*gamma globulin
Mostly in gamma fraction |
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Term
| Types of T cells & their functions |
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Definition
*Supressor T cells-(regulatory Tcells):
Regulate immune responses/turn off response after overcoming antigen
*Cytotoxic T cells:Kill cancer & virus infected cells
*Helper T cells:Helps B lymphocytes produce antibodies
*Delayed hypersensitivity T cell:Involved in allergic reaction |
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Term
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Definition
*Structure-Pentamer bound at Fc, stabilized by J chain polypeptide
*Valence=10
*10% total serum Ab
*Location-Blood/Lymph/B cell surface(receptors)
*Molecular Wt-970K (biggest)
*Complement fixation YES
*IgM Ab bound to microbe surface act as opsonins/attracting phagocytosis
*Function -First antibodies produced in response to initial infection |
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Term
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Definition
*Structure-Dimer/secretions & monomer/serum
*Valence=4
*Synthesized in GALT/secreted onto mucosal surfaces/protectant
*Neutralize toxin on mucosal surfaces
*Location-Secretions
*Function-protection on mucosal surfaces |
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Term
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Definition
*Structure-Monomer
*Location-B cell surface, blood, lymph
*Function -Presence on B cells in initiation of immune response |
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Term
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Definition
*Structure -Monomer
*80% total serum antibody (most %)
*Location -Blood, lymph, intestine
*Half-life serum 23 days (Old)
*Complement fixation YES
*Function-Enhances phagocytosis
Neutralizes toxins/viruses
Protects fetus & newborn
*Placental transfer YES |
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Term
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Definition
*Structure-Monomer
*0.002% total serum antibody (lowest)
*Location-Mast & basophils throughout body, blood
*Function -Allergic reactions; possibly lysis of parasitic worms |
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