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Special Considerations and Cell Phases
Pharmacology Exam 3
26
Pharmacology
Professional
04/01/2013

Additional Pharmacology Flashcards

 


 

Cards

Term
IV administration only
Definition
mechloroethamine, anthracyclines
Term
IV, Intra-arterial, Intrathecally and oral administration routs
Definition
methotrexate
Term
IV and oral administration
Definition
cyclophosfamide, epipodopyllotoxins (oral is only 50% bioavail)
Term
prevents multidrug resistance in tumor seen with anthracyclines
Definition
verapamil; inhibits active transport by inhibiting ATP binding causing a dysfunctional pump
Term
irreversible cardiotoxicity
Definition
doxorubacin, daunorubacin
Term
metal chelating agent that binds Fe/OH product used to mitigate anthracycling-associated cardiotoxicity
Definition
Dexrazosin
Term
Used to treat mitomycin-induced Hemolytic-uremic syndrome
Definition
catopril, heparin and prednisone
Term
FH2 rescue after high dose methotrexate
Definition
Leucovorin
Term
6-MP-induced hyperuricemia
Definition
lower dose and add allopurinol, no dose adjustment for 6-TG
Term
extavasation
Definition
mechloroethamine, anthracyclines (mitoxantrone less so), mitomycin, and vinca alkaloids
Term
albumin-bound paclitaxel dosage form option for taxane-induced HS
Definition
Abraxane
Term
pulmonary toxicity
Definition
mitomycin
Term
nephrotoxicity
Definition
cisplatin/ carboplatin and methotrexate (precipitation of 7OH metabolite)
Term
hemorrhagic cystitis
Definition
cyclophosphamide
Term
cardiotoxicity
Definition
doxorubacin (daunorubacin), carboplatin
Term
hepatotoxicity
Definition
methotrexate, cytarabine, 6-MP (6-TG less so)
Term
neurotoxic
Definition
vincristine, taxanes
Term
non-cell phase specific
Definition
alkylating agents and cisplatin
Term
S-Phase specific
Definition
antimetabolites, except 5-FU
Term
5-FU
Definition
non-phase specific because it acts on both the DNA and RNA
Term
M-phase specific
Definition
vinka alkaloids
Term
cell cycle non-specific but maximal kill in G1 and S-phase
Definition
mitomycin
Term
G0 and G2 most sensitive
Definition
bleomycin
Term
etoposide or VP-16
Definition
S-phase specific
Term
taxanes; paclitaxel and docetaxel
Definition
M-phase specific
Term
SN-38 metabolite
Definition
metabolite of CTP-11 (irinotecan) that is 1000-fold more potent, if there is mutation in conjugation step of metabolism this metabolite is not excreted causing toxicity
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